Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression

American Journal of Psychiatry

Volumn 160, Issue 2, 2003, Pages 374-376

  Davies, Julia ^b   Lloyd, Keith R ^a   Jones, Ivor K ^b   Barnes, Anna ^b   Pilowsky, Lyn S ^b  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; VENLAFAXINE; CYCLOHEXANOL DERIVATIVE; DIAGNOSTIC AGENT;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BRAIN BLOOD FLOW; CEREBELLUM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; HAMILTON SCALE; HUMAN; MAJOR DEPRESSION; MALE; OCCIPITAL LOBE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RATING SCALE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATISTICAL SIGNIFICANCE; TEMPORAL CORTEX; THALAMUS; BLOOD FLOW; BRAIN; BRAIN CORTEX; DEPRESSION; LIMBIC SYSTEM; MIDDLE AGED; PATHOPHYSIOLOGY; PSYCHOLOGICAL RATING SCALE; SCINTISCANNING; TREATMENT OUTCOME; VASCULARIZATION;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BRAIN; CEREBRAL CORTEX; CYCLOHEXANOLS; DEPRESSIVE DISORDER; FEMALE; HUMANS; LIMBIC SYSTEM; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; REGIONAL BLOOD FLOW; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 0037313074     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.2.374     Document Type: Article

References (11)

1. Post RM, DeLisi LE, Holcomb HH, Uhde TW, Cohen R, Buchsbaum MS: Glucose utilization in the temporal cortex of affectively ill patients: positron emission tomography. Biol Psychiatry 1987; 22:545-553
2. Schlegel S, Aldenhoff JB, Eissner D, Lindner P, Nickel O: Regional cerebral blood flow in depression: association with psychopathology. J Affect Disord 1989; 17:211-218
3. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RSJ, Dolan RJ: The anatomy of melancholia - focal abnormalities of cerebral blood flow in major depression. Psychol Med 1992; 22:607-615
4. Effexor - Venlafaxine Hydrochloride. Taplow, Maidenhead, Berkshire, UK, Wyeth Laboratories, January 1999
5. Hamilton M: Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6:278-296
6. Beck AT, Rush AJ, Shaw BF, Emery G: Cognitive Therapy of Depression. Chichester, UK, John Wiley & Sons, 1979, pp 1-230
7. Ashburner J, Friston K: Multimodal image coregistration and partitioning - a unified framework. Neuroimage 1997; 6:209-217
8. Martin SD, Martin E, Rai SS, Richardson MA, Royall R: Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: preliminary findings. Arch Gen Psychiatry 2001; 58:641-648
9. Mayberg HS, Lewis PJ, Regenold W, Wagner HN Jr: Paralimbic hypoperfusion in unipolar depression. J Nucl Med 1994; 35:929-934
10. Sackeim HA, Prohovnik I, Mueller JR, Brown RP, Apter S, Prudic J, Devanand DP, Mukherjee S: Regional cerebral blood flow in mood disorders, I: comparison of major depressives and normal controls at rest. Arch Gen Psychiatry 1990; 47:60-70
11. Little JT, Ketter TA, Kimbrell TA, Danielson A, Benson B, Willis MW, Post RM: Venlafaxine or bupropion responders but not nonresponders show baseline prefrontal and paralimbic hypometabolism compared with controls. Psychopharmacol Bull 1996; 32:629-635