Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective b 3-adrenergic receptor agonists

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 4, 2010, Pages 533-545

  Maruyama, Tatsuya ^a   Onda, Kenichi ^a   Hayakawa, Masahiko ^a   Suzuki, Takayuki ^a   Kimizuka, Tetsuya ^a   Matsui, Tetsuo ^a   Takasu, Toshiyuki ^a   Nagase, Itsuro ^a   Hamada, Noritaka ^a   Ohta, Mitsuaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

3 adrenergic receptor; Acetanilide; Agonist; Diabetes; Phenylethanolamine

Indexed keywords

2 (2 AMINO 5 METHYLTHIAZOL 4 YL) 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL]ACETANILIDE; 2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL]ACETANILIDE; 2 (6 AMINO 2 PYRIDYL) 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL]ACETANILIDE; 2 (6 CHLORO 2 PYRIDYL) 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL]ACETANILIDE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4' [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO] 2 METHYLPROPYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHYL] 2 (3 PYRIDYL)ACETANILIDE; 4' [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHYL] 2 (QUINOLIN 2 YL)ACETANILIDE; 4' [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 (3 ACETAMIDO 4 HYDROXYPHENYL) 2 HYDROXYETHYL]AMINO]ETHYL) 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 (3 FLUOROPHENYL) 2 HYDROXYETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 (3 FORMAMIDO 4 HYDROXYPHENYL) 2 HYDROXYETHYL]AMINO]ETHYL) 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 (4 FLUOROPHENYL) 2 HYDROXYETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 HYDROXY 2 (3 HYDROXYPHENYL)ETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 HYDROXY 2 (3 PYRIDYL)ETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 HYDROXY 2 (4 HYDROXY 3 METHYLSULFONAMIDOPHENYL)ETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [2 [[2 HYDROXY 2 (4 HYDROXYPHENYL)ETHYL]AMINO]ETHYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL] 2 (2 PYRIDYL)ACETANILIDE; 4' [3 [(2 HYDROXY 2 PHENYLETHYL)AMINO]PROPYL] 2 (6 HYDROXY 2 PYRIDYL)ACETANILIDE; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHOXY] 2 (2 PYRIDYL)ACETANILIDE; ACETANILIDE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOSE; PHENYLETHANOLAMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; MOUSE; NONHUMAN; OBESITY;

ADRENERGIC AGONISTS; ANIMALS; BLOOD GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENETHYLAMINES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3;

EID: 77950800340     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.533     Document Type: Article

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