Antihyperlipidemic activity of 3-Hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats

Journal of Biochemical and Molecular Toxicology

Volumn 24, Issue 2, 2010, Pages 95-101

  Chandramohan, Govindasamy ^a   Al Numair, Khalid S ^a   Sridevi, Muruhan ^b   Pugalendi, Kodukkur Viswanathan ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

3 Hydroxymethyl Xylitol; Antihyperlipidemic; Casearia esculenta; Glibenclamide; Streptozotocin

Indexed keywords

3 HYDROXYMETHYL XYLITOL; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CHOLESTEROL; FATTY ACID; GLIBENCLAMIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; 3-HYDROXYMETHYLXYLITOL; XYLITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERLIPIDEMIC ACTIVITY; ARTICLE; BRAIN; CASEARIA; CASEARIA ESCULENTA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; DRUG ACTIVITY; DRUG ISOLATION; FATTY ACID BLOOD LEVEL; HEART; HISTOLOGY; KIDNEY; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIVER; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PLANT ROOT; RAT; STREPTOZOCIN DIABETES; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ISOLATION AND PURIFICATION; PATHOLOGY; PHYTOTHERAPY;

CASEARIA; RATTUS;

ANIMALS; CASEARIA; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; FATTY ACIDS, NONESTERIFIED; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LIVER; MALE; PHOSPHOLIPIDS; PHYTOTHERAPY; PLANT ROOTS; RATS; RATS, WISTAR; STREPTOZOCIN; TRIGLYCERIDES; XYLITOL;

EID: 77950786793     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20317     Document Type: Article

References (31)

1. Jensen T, Stender S, Deckert T. Abnormalities in plasma concentrations of lipoprotein and fibrinogen in type 1 (insulin-dependent) diabetic patients with increased urinary albumin excretion. Diabetologia 1988;31:142-145.
2. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-412.
3. Brown DJ, Goodman J. A review of vitamins A, C, and E and their relationship to cardiovascular disease. Clin Excellence Nurs Pract 1998;2:10-12.
4. Ross R. The pathogenesis of atherosclerosis.N Engl J Med 1986;314:488-500.
5. Eder HA, Bergman M. Metabolism of plasma lipids and lipoproteins. diabetes mellitus: Theory and practice, 3rd edition. New York:Medical Examination Publishing; 1990. pp 61-72.
6. UKPDS. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837-853.
7. Deedwania PC. Hypertension and diabetes: New therapeutic options. Arch Intern Med 2000;160:1585-1594. (Pubitemid 30367896)
8. Betteridge J. Lipid disorders in diabetes mellitus. In: Pickup JC, Williams G, editors. Text Book of diabetes, 2nd edition. London: Blackwell Science; 1997. pp 1-55.
9. Kritchevsky D. Dietary protein, cholesterol and atherosclerosis: A review of the early history. J Nutr 1995;125:S589-S593.
10. Asolkar LV, Kakkar KK, Chakre OJ. Glossary of Indian medicinal plants with active principles. Part I (A-K series). New Delhi, India: Publication and Information Directorate, CSIR; 1992. p 176.
11. Wealth of India. A dictionary of Indian raw materials and industrial products. Raw Material Ca-Ci series; Council of Scientific and Industrial Research (CSIR),New Delhi, 1992;Vol3:p 325.
12. Yoganarasimhan SN. Medicinal plants of India. India: International Book Publisher; 2000. pp 109-110.
13. Prakasam A, Sethupathy S, Pugalendi KV. Hypolipidemic effect of Casearia esculenta root extract in streptozotocin diabetic rats. Pharmazie 2003;58:828-832. (Pubitemid 37462468)
14. Prakasam A, Sethupathy S, Pugalendi KV. Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Pharmazie 2002;57:758-760. (Pubitemid 35339954)
15. Chandramohan G, Pugalendi KV, Ignacimuthu S. A process for preparation of a novel compound 3-hydroxymethyl xylitol with antidiabetic activity. The Patent Office J 2007;2602.
16. Chandramohan G, Ignacimuthu S, Pugalendi KV. A novel compound fromCasearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocindiabetic rats. Eur J Pharmacol 2008;590:437-443.
17. Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475.
18. McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 1983;29:538-542. (Pubitemid 13160770)
19. Falholt K, Lund B, Falholt W. An easy colorimetric method for routine determination of free fatty acids in the plasma. Clin Chim Acta 1973;46:105-111.
20. Zilversmit DB, Davis AK.Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 1950;35(1):155-160.
21. Izzo C, Grillo F, Murador E. Improvedmethod for the determination of high density lipoprotein cholesterol. Clin Chem 1981;27:371-374.
22. Friedwald WT, Levy RJ, Fredricken DS. Estimation of VLDL-cholesterol in the plasma without the use of preparative ultracentrifuge. Clin Chem 1972;18:449.
23. Sachdewa A, Khemani LD. Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats. J Ethnopharmacol 2003;89:61-66. (Pubitemid 37163800)
24. Rhoads GG, Gulbrandse CL, Kagan A. Serum lipoproteins and coronary artery diseases in a population study of Hawaii, a Japanese man. N Eng J Med 1976;294:293-298.
25. Goodman LS, Gilman A. The pharmacological basis of therapeutics, 7th edition. New York: McMillan; 1985. p 490.
26. McKenney JM. Pharmacotherapy of dyslipidemia. Cardiovasc Drugs Ther 2001;15:413-422.
27. Segal P, Bachorik PS, Rifkind BM, Levy RI. Lipids and lipoproteinemia. In: Henry JB, editor. Clinical diagnosis and management by laboratory methods. Philadelphia, PA:WB Saunders; 1984. pp 180-203.
28. Lehto S, Haffner SM, Pyorala K, Kallio V, Laakso M. Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes 1997;46:1354-1359. (Pubitemid 27315286)
29. Bopanna KN, Kannan J, Sushma G, Balaraman R, Rathod SP. Antidiabetic and antihyperlipemic effects of neem seed kernel powder on alloxan diabetic rabbits. Ind J Pharmacol 1997;29:162-167. (Pubitemid 27296934)
30. Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA.Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol 1990;259:E736-E750. (Pubitemid 20385723)
31. Chakrabarti S, Biswas TK, Rokeya B, Ali L, Mosihuzzaman M, NaharN, Azad Khan,AK, Mukherjee B. Advanced studies on the hypoglycemic effect of Caesalpinia bonducella F. in type 1 and 2 diabetes in long evens rats. J Ethanopharmacol 2003;84:41-46. (Pubitemid 36034234)