A DNA vaccine-encoded nucleoprotein of influenza virus fails to induce cellular immune responses in a diabetic mouse model

Clinical and Vaccine Immunology

Volumn 17, Issue 4, 2010, Pages 683-687

  Jamali, Abbas ^a   Sabahi, Farzaneh ^a   Bamdad, Taravat ^a   Hashemi, Hamidreza ^a   Mahboudi, Fereidoun ^b   Kheiri, Masume Tavasoti ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; VIRUS NUCLEOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DIABETES MELLITUS; DRUG EFFICACY; IMMUNIZATION; INFLUENZA; INFLUENZA VIRUS; INJECTION; LUNG; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION;

ANIMALS; CELL PROLIFERATION; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; IMMUNITY, CELLULAR; IMMUNIZATION, SECONDARY; INFLUENZA VACCINES; INJECTIONS, INTRAMUSCULAR; INTERFERON-GAMMA; LUNG; LYMPHOCYTES; MALE; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; RNA-BINDING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES, DNA; VIRAL CORE PROTEINS;

EID: 77950669894     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00445-09     Document Type: Article

References (31)

1. Calvet, H. M., and T. T. Yoshikawa. 2001. Infection in diabetes. Infect. Dis. Clin. North Am. 15:407-421.
2. Carrat, F., and A. Flahault. 2007. Influenza vaccine: the challenge of antigenic drift. Vaccine 25:6852-6862.
3. Diepersloot, R. J., K. P. Bouter, W. E. Beyer, J. B. Hoekstra, and N. Masurel. 1987. Humoral immune response and delayed type hypersensitivity to influenza vaccine in patients with diabetes mellitus. Diabetologia 30:397-401.
4. Donnelly, J. J., J. B. Ulmer, J. W. Shiver, andM. A. Liu. 1997. DNA vaccines. Annu. Rev. Immunol. 15:617-648.
5. Drape, R. J., M. D. Macklin, L. J. Barr, S. Jones, J. R. Haynes, and H. J. Dean. 2006. Epidermal DNA vaccine for influenza is immunogenic in humans. Vaccine 24:4475-4481.
6. Drell, D. W., and A. L. Notkins. 1987. Multiple immunological abnormalities in patients with type 1 (insulin dependent) diabetes mellitus. Diabetologia 30:132-143.
7. Epstein, S. L., W. Kong, J. A. Misplon, C. Y. Loa, T. M. Tumpey, L. X. Gary, and J. Nabel. 2005. Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 23:5404-5410.
8. Epstein, S. L., A. Stack, J. A. Misplon, C. Y. Lo, H. Mostowski, J. Bennink, and K. Subbarao. 2000. Vaccination with DNA encoding internal proteins of influenza virus does not require CD8+ cytotoxic T lymphocytes: either CD4+ or CD8+ T cells can promote survival and recovery after challenge. Int. Immunol. 12:91-101.
9. Geerlings, S. E., and A. Hoepelman. 1999. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol. Med. Microbiol. 26:259-265.
10. Giese, M. 1998. DNA-antiviral vaccines: new development and approaches\a review. Virus Genes 17:211-232.
11. Jamali, A., M. H. Roostaee, H. Soleimanjahi, F. Ghaderi Pakdel, and T. Bamdad. 2007. DNA vaccine-encoded glycoprotein B of HSV-1 fails to protect chronic morphine-treated mice against HSV-1 challenge. Comp. Immunol. Microbiol. Infect. Dis. 30:71-80.
12. James, C. M., M. Y. Abdada, J. P. Mansfield, H. K. Jacobsen, A. Rezazadeh, P. A. Stumbles, and E. J. Bartlett. 2007. Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein. Vaccine 25:1856-1867.
13. Kaiser, J. 2006. A one-size-fits-all flu vaccine? Science 312:380-382.
14. Katz, S., B. Klein, I. Elian, P. Fishman, and M. Djaldetti. 1983. Phagocytotic activity of monocytes from diabetic patients. Diabetes Care 6:479-482.
15. Kaye, W. A., M. N. S. Adri, J. S. Soeldner, S. L. Rabinowe, A. Kaldany, C. R. Kahn, B. Bistrian, S. Srikanta, O. P. Ganda, and G. S. Eisenbarth. 1986. Acquired defect in interleukin-2 production in patients with type 1 diabetes mellitus. N. Engl. J. Med. 315:920-924.
16. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
17. Nass, P. H., K. L. Elkins, and J. P. Weir. 2001. Protective immunity against herpes simplex virus generated by DNA vaccination compared to natural infection. Vaccine 19:1538-1546.
18. Nguyen-Van-Tam, J. S., and A. W. Hampson. 2003. The epidemiology and clinical impact of pandemic influenza. Vaccine 21:1762-1768.
19. Ohba, K., S. Yoshid, Z. Dewan, H. Shimura, N. Sakamaki, F. Takeshita, N. Yamamoto, and K. Okuda. 2007. Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity. Vaccine 25:4291-4300.
20. Orban, T., J. Kis, L. Szereday, P. Engelmann, K. Farkas, H. Jalahej, and A. Treszl. 2007. Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus. J. Autoimmun. 28:177-187.
21. Reading, P. C, J. Allison, E. C. Crouch, and E. M. Anders. 1998. Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin-mediated host defense of the lung by glucose? J. Virol. 72:6884-6887.
22. Roy, S., G. P. Kobinger, J. Lin, J. Figueredo, R. Calcedo, D. Kobas, and J. M. Wilson. 2007. Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein. Vaccine 25:6845-6851.
23. Saha, S., S. Yoshida, K. Ohba, K. Matsui, T. Matsuda, F. Takeshita, K. Umeda, Y. Tamura, K. Okuda, D. Klinman, K. Q. Xin, and K. Okuda. 2006. A fused gene of nucleoprotein (NP) and herpes simplex virus genes (VP22) induces highly protective immunity against different subtypes of influenza virus. Virology 354:48-57.
24. Spatz, M., N. Eibl, S. Hink, H. M. Wolf, G. F. Fischer, R. Mayr, G. Schern-thaner, and M. M. Eibl. 2003. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell. Immunol. 221:15-26.
25. Subbarao, K., and J. Katz. 2000. Avian influenza viruses infecting humans. Cell Mol. Life Sci. 57(12):1770-1784.
26. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
27. Ulmer, J. B., R. R. Deck, C. M. DeWitt, A. Friedman, J. J. Donnelly, and M. A. Liu. 1994. Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccine 12:1541-1544.
28. Valdez, R., K. M. V. Narayan, L. S. Geiss, and M. M. Engelgau. 1999. The impact of diabetes mellitus on mortality associated with pneumonia and influenza among non-Hispanic black and white U.S. adults. Am. J. Public Health 89:1715-1721.
29. Wright, P. F., G. Neumann, and Y. Kawaoka. 2007. Orthomyxoviruses, p. 1691-1740. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), Fields virology, vol.2, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
30. Yamashiro, S., K. Kawakami, K. Uezu, T. Kinjo, K. Miyagi, K. Nakamura, and A. Saito. 2005. Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with Mycobacterium tuberculosis. Clin. Exp. Immunol. 139:57-64.
31. Zhu, Q., H. Chang, Y. Chen, F. Fang, C. Xue, F. Zhang, M. Qiu, H. Wang, H. Wang, and Z. Chen. 2005. Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice. Biochem. Bio-phys. Res. Commun. 329:87-94.