Synthesis of 9,9-dialkyl-4,5-diazafluorene derivatives and their structure-activity relationships toward human carcinoma cell lines

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 559-566

  Wang, Qiwei ^a   Yuen, Marcus Chun Wah ^b   Lu, Guo Liang ^b   Ho, Cheuk Lam ^b   Zhou, Gui Jiang ^a   Keung, Oi Mei ^a   Lam, Kim Hung ^b   Gambari, Roberto ^c   Tao, Xiao Ming ^b   Wong, Raymond Siu Ming ^d   Tong, See Wai ^d   Chan, Kit Wah ^d   Lau, Fung Yi ^d   Cheung, Filly ^b   Cheng, Gregory Yin Ming ^d   Chui, Chung Hin ^b,d   Wong, Wai Yeung ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c UNIVERSITY OF FERRARA   (Italy)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cytotoxicity; Diazafluorenes; Hepatoma; Synthesis; Xenografts

Indexed keywords

9,9 DIBUTYL 4,5 DIAZAFLUORENE; 9,9 DIDODECYL 4,5 DIAZAFLUORENE; 9,9 DIETHYL 4,5 DIAZAFLUORENE; 9,9 DIHEXADECYL 4,5 DIAZAFLUORENE; 9,9 DIHEXYL 4,5 DIAZAFLUORENE; 9,9 DIOCTYL 4,5 DIAZAFLUORENE; 9,9 DIPROPYL 4,5 DIAZAFLUORENE; ALKYL GROUP; BROMIDE; CISPLATIN; DOXORUBICIN; FLUORENE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FEMALE; FLUORENES; HUMANS; LIVER NEOPLASMS; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77950661898     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000034     Document Type: Article

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