A small-animal PET system based on LYSO crystal arrays, PS-PMTs and a PCI DAQ board

IEEE Transactions on Nuclear Science

Volumn 57, Issue 1 PART 1, 2010, Pages 85-93

  Alva Sanchez H ^a   Murrieta, T ^a   Moreno Barbosa, E ^a   Brandan, M E ^a   Ruiz Trejo, C ^a   Martinez Davalos A ^a   Rodriguez Villafuerte M ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

H8500; LYSO; PS PMT; Small animal PET

Indexed keywords

DEAD TIME; DETECTION MODULES; DIGITAL ACQUISITION; ENERGY RESOLUTIONS; FRONT END ELECTRONICS; GLASS CAPILLARIES; LYSO CRYSTALS; MAXIMUM VALUES; ME-XICO; MOUSE PHANTOMS; NOISE EQUIVALENT COUNT RATES; OUTPUT SIGNAL; PCI DAQ BOARDS; PEAK-TO-VALLEY RATIOS; POSITION SENSITIVE PHOTOMULTIPLIER TUBE; POSITRON EMISSION; READ-OUT CIRCUIT; SCATTER FRACTIONS; SIGNAL DIGITIZATION; SMALL ANIMAL; SMALL ANIMAL PET; SYSTEM SENSITIVITY; SYSTEM-BASED; TIMING RESOLUTIONS; VOLUME SOURCE;

ANIMALS; PHOTOMULTIPLIERS; SIGNAL DETECTION; SIGNAL PROCESSING; SODIUM; THREE TERM CONTROL SYSTEMS; TIME MEASUREMENT;

POSITRON EMISSION TOMOGRAPHY;

EID: 77950654233     PISSN: 00189499     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNS.2009.2038052     Document Type: Article

References (34)

1. P. D. Cutler, S. R. Cherry, E. J. Hoffman, and W. M. Digby, "Design features and performance of a PET system for animal research," J. Nucl. Med., vol. 33, pp. 595-604, 1992.
2. M. Watanabe, H. Uchida, H. Okada, K. Shimizu, N. Satoh, E. Yoshikawa, T. Ohmura, T. Yamashita, and E. Tanaka, "A high resolution PET for animal studies," IEEE Trans. Med. Imag., vol. 1-4, pp. 577-580, 1992.
3. R. Lecomte, J. Cadorette, P. Richard, S. Rodriguez, and D. Rouleau, "Design and engineering aspects of a high resolution positron tomograph for small animal imaging," IEEE Trans. Nucl. Sci., vol. 41, no. 4, pp. 1446-1452, Aug. 1994.
4. P. M. Bloomfield, S. Rajeswaran, T. J. Spinks, S. P. Hume, R. Myers, S. Ashworth, K. M. Clifford, W. F. Jones, L. G. Byars, J. Young, M. Andreaco, C. W. Williams, A. A. Lammertsma, and T. Jones, "The design and physical characteristics of a small animal positron emission tomograph," Phys. Med. Biol., vol. 40, pp. 1105-1126, 1995.
5. M. Watanabe, H. Okada, K. Shimizu, T. Omura, E. Yoshikawa, T. Kosugi, S. Mori, and T. Yamashita, "A high resolution animal PET scannerusing compactPS-PMT detectors," IEEE Trans. Nucl. Sci., vol. 44, no. 3, pp. 1277-1282, Jun. 1997.
6. S. Siegel, J. J. Vaquero, L. Aloj, J. Seidel, E. Jagoda, W. R. Gandler, W. C. Eckelman, and M. V. Green, "Initial results from a PET/planar small animal imaging system," IEEE Trans. Nucl. Sci., vol. 46, no. 3, pp. 571-575, Jun. 1999.
7. S. Weber, A. Terstegge, H. Herzog, R. Reinartz, P. Reinhart, F. Rongen, H. W. Muller-Gartner, and H. Halling, "The design of an animal PET: Flexible geometry for achieving optimal spatial resolution or high sensitivity," IEEE Trans. Med. Imag., vol. 16, pp. 684-689, 1997.
8. A. Del Guerra, G. Di Domenico, M. Scandola, and G. Zavattini, "YAP- PET: A small animal positron emission tomograph based on YAP:Ce finger crystals," in Proc. IEEE Nuclear Science Symp., 1997, vol. 2,pp. 1640-1643.
9. A. Del Guerra, G. Di Domenico, M. Scandola, and G. Zavattini, "YAP- PET: First results of a small animal positron emission tomograph based on YAP: Ce finger crystals," IEEE Trans. Nucl. Sci., vol. 45, no. 6, pp. 3105-3108, Dec. 1998.
10. A. Del Guerra, C. Damiani, G. Di Domenico, M. Giganti, A. Motta, A. Piffanelli, L. Uccelli, G. Zavattini, V. Bettinardi, M. C. Gilardi, R. M. Moresco, and F. Fazio, "First in vivo studies on rats with the YAPPET scanner," in Proc. IEEE Nuclear Science Symp., 1999, vol. 3, pp. 1475-1478.
11. S. R. Cherry, Y. Shao, R. W. Silverman, K. Meadors, S. Siegel, A. F. Chatziioannou, J. W. Young, W. F. Jones, J. C. Moyers, D. Newport, A. Boutefnouchet, T. H. Farquhar, M. Andreaco, M. J. Paulus, D. M. Binkley, R. Nutt, and M. E. Phelps, "MicroPET: A high resolution PET scanner for imaging small animals," IEEE Trans. Nucl. Sci., vol. 44, no. 3, pp. 1161-1166, Jun. 1997.
12. B. Pichler, C. Boning, E. Lorenz, R. Mirzoyan, W. Pimpl, M. Schwaiger, and S. I. Ziegler, "Studies with a prototype high resolution PET scanner based on LSO-APD modules," IEEE Trans. Nucl. Sci., vol. 45, no. 3, pp. 1298-1302, Jun. 1998.
13. J. J. Vaquero, J. Seidel, S. Siegel, W. R. Gandler, and M. V. Green, "Performance characteristics of a compact position-sensitive LSO detector module," IEEE Trans. Med. Imag., vol. 17, pp. 967-978, 1998.
14. J. A. Correia, C. A. Burnham, D. Kaufman, and A. J. Fischman, "Development of a small animal PET imaging device with resolution approaching l mm," IEEE Trans. Nucl. Sci., vol. 46, no. 3, pp. 631-635, Jun. 1999.
15. A. F. Chatziioannou, S. R. Cherry, Y. Shao, R. W. Silverman, K. Meadors, T. H. Farquhar, M. Pedarsani, and M. E. Phelps, "Performance evaluation of microPET: A high-resolution lutetium oxyorthosilicate PET scanner for animal imaging," J. Nucl. Med., vol. 40, pp. 1164-1175, 1999.
16. Y. Shao, S. R. Cherry, and A. F. Chatziioannou, "Design and development of 1 mm resolution PET detectors with position-sensitive PMTs," Nucl. Instrum. Methods Phys. Res. A, vol. A477, pp. 486-490, 2002.
17. J. Joung, R. S. Miyaoka, and T. K. Lewellen, "cMiCE: A high resolution animal PET using continuous LSO with a statistics based positioning scheme," Nucl. Instrum. Methods Phys. Res. A, vol. A489, pp. 584-598, 2002.
18. Y. C. Tai, A. F. Chatziioannou, Y. Yang, R. W. Silverman, K. Meadors, S. Siegel, D. F. Newport, J. R. Stickel, and S. R. Cherry, "Micro PET II: Design, development and initial performance of an improved mi- croPET scanner for small-animal imaging," Phys. Med. Biol., vol. 48, pp. 1519-1537, 2003.
19. N. C. Rouze, V. C. Soon, J. W. Young, S. Siegel, and G. D. Hutchins, "Initial evaluation of the Indiana small animal PET scanner," in Proc. IEEE Nuclear Science Symp. Conf. Rec., 2005, vol. M09-8, pp. 2394-2398.
20. J. M. Benlloch, V. Carrilero, A. J. Gonzalez, J. Catret, Ch. W. Lerche, D. Abellan, F. Garcia De Quiros, M. Gimenez, J. Modia, F. Sanchez, N. Pavon, A. Ros, J. Martinez, and A. Sebastia, "Scanner calibration of a small animal PET camera based on continuous LSO crystals and flat panel PSPMTs," Nucl. Instrum. Methods Phys. Res. A, vol. A571, pp. 26-29, 2007. (Pubitemid 46151702)
21. S. Surti, J. S. Karp, A. E. Perkins, C. A. Cardi, M. E. Daube-Wither-spoon, A. Kuhn, and G. Muehllehner, "Imaging performance ofa-PET: A small animal PET camera," IEEE Trans. Med. Imag., vol. 24, pp. 844-852, 2005.
22. N. Ollivier-Henry, J. D. Berst, C. Colledani, Ch. Hu-Guo, N. A. Mbow, D. Staub, J. L. Guyonnet, and Y. Hu, "A front-end readout mixed chip for high-efficiency small animal PET imaging," Nucl. Instrum. Methods Phys. Res. A, vol. A571, pp. 312-316, 2007.
23. Y. C. Tai and R. Laforest, "Instrumentation aspects of animal PET," Annu. Rev. Biomed. Eng., vol. 7, pp. 255-285, 2005.
24. M. S. Judenhofer, B. J. Pichler, and S. R. Cherry, "Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors," Phys. Med. Biol., vol. 50, pp. 29-44,2005.
25. H. Alva-Sánchez, A. Martínez-Dávalos, E. Moreno-Barbosa, B. Hernandez-Reyes, T. Murrieta, C. Ruiz-Trejo, M. E. Brandan, and M. Rodriguez-Villafuerte, "Energy calibration of individual crystals in a LYSO pixelated array for microPET detection modules using Voronoi diagrams," Nucl. Instrum. Methods Phys. Res. A, vol. A596, no. 3, pp. 384-389, 2008.
26. H. Alva-Sanchez, A. Martinez-Davalos, E. Moreno-Barbosa, B. Hernandez-Reyes, T. Murrieta, C. Ruiz-Trejo, M. E. Brandan, and M. Rodriguez-Villafuerte, "Initial characterization of a benchtop microPET system based on LYSO crystal arrays and Hamamatsu H8500 PS-PMTs," Nucl. Instrum. Methods Phys. Res. A, vol. A604, pp. 335-338, 2009.
27. S. Siegel, R. W. Silverman, Y. Shao, and S. R. Cherry, "Simple charge division readouts for imaging scintillator arrays using a multi-channel PMT," IEEE Trans. Nucl. Sci., vol. 43,no.3,pp. 1634-1641, Jun. 1996.
28. E. J. Hoffman, T. M. Guerrero, G. Germano, W. M. Digby, and M. Dahlbom, "PET system calibrations and corrections for quantitative and spatially accurate images," IEEE Trans. Nucl. Sci., vol. 36, no. 1, pp. 1108-1112, Feb. 1989.
29. G. Knoll, Radiation Detection and Measurements, 3rd ed. New York: Wiley, 2000.
30. D. L. Bailey, T. Jones, and T. J. Spinks, "A method for measuring the absolute sensitivity of positron emission tomographic scanners," Eur. J. Nucl. Med., vol. 18-6, pp. 374-379, 1991.
31. Y. Yang and S. R. Cherry, "Observations regarding scatter fraction and NEC measurements for small animal PET," IEEE Trans. Nucl. Sci., vol. 53, no. 1, pp. 127-132, Feb. 2006.
32. V. A. Rosslyn, National Electrical Manufacturers Association, "NEMA standards publication NU 2-2001: Performance measurements of positron emission tomographs," 2001.
33. Positron Emission Tomography: Basic Sciences, D. L. Bailey, D. W. Townsend, P. E. Valk, and M. N. Maisey, Eds., 1st ed. New York: Springer, 2005.
34. M. E. Daube-Witherspoon and G. Muehllehner, "Treatment of axial data in three-dimensional PET," J. Nucl. Med., vol. 28, pp. 1717-1724, 1987.