A novel porous bioceramics scaffold by accumulating hydroxyapatite spherules for large bone tissue engineering in vivo. I. Preparation and characterization of scaffold

Journal of Biomedical Materials Research - Part A

Volumn 93, Issue 3, 2010, Pages 920-929

  Peng, Qian ^a   Jiang, Faxing ^a   Huang, Peng ^a,b   Zhou, Shaobing ^a   Weng, Jie ^a   Bao, Chongyun ^c   Zhang, Cong ^b   Yu, Haiyang ^c  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

^b 452nd Hospital of Chinese PLA   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Ceramic spherules; HA bioceramics; Interconnected pores; Mechanical strength; Tissue engineering scaffold

Indexed keywords

BIOLOGICAL SUBSTANCE; BONE TISSUE; BONE TISSUE ENGINEERING; HYBRID SCAFFOLDS; IN-SITU; IN-VIVO; INTERCONNECTED PORES; LARGE DIMENSIONS; MECHANICAL STRENGTH; OIL TEMPERATURE; PILOT STUDIES; POLY(L-LACTIC ACID); POROUS BIOCERAMIC; STIRRING RATES; THIN LAYERS; TISSUE ENGINEERING SCAFFOLD;

APATITE; BIOCERAMICS; BONE; COAGULATION; EMULSIFICATION; GELATION; HYDROXYAPATITE; HYDROXYLATION; INTERCONNECTION NETWORKS; LACTIC ACID; ORGANIC ACIDS; TISSUE ENGINEERING;

SCAFFOLDS;

BIOCERAMICS; CHITIN; HYDROXYAPATITE; MOLECULAR SCAFFOLD; OIL; POLYLACTIC ACID;

ANALYTICAL PARAMETERS; ARTICLE; BIOACCUMULATION; BONE TISSUE; EMULSION; GELATION; HYBRID; IN VIVO STUDY; MUSCLE; PERITONEUM; PILOT STUDY; POROSITY; TEMPERATURE; TISSUE ENGINEERING;

BONE AND BONES; CERAMICS; COATED MATERIALS, BIOCOMPATIBLE; COMPRESSIVE STRENGTH; DURAPATITE; IMPLANTS, EXPERIMENTAL; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POROSITY; POWDERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE ENGINEERING; TISSUE SCAFFOLDS; X-RAY DIFFRACTION;

EID: 77950642060     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32408     Document Type: Article

References (49)

1. Service RF. Tissue engineers build new bone. Science 2000;289:1498-1500.
2. Goldberg VM, Stevenson S. Natural history of autografts and allografts. Clin Orthop 1987;225:7-16.
3. Costantino PD, Friedman CD. Synthetic bone graft substitutes. Otolaryngol Clin North Am 1994;27:1037-1074.
4. Bonfiglio M, Jeter WS. Immunological responses to bone. Clin Orthop 1972;87:19-27.
5. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
6. Braddock M, Houston P, Campbell C, Ashcroft P. Born again bone: Tissue engineering for bone repair. News Physiol Sci 2001;16:208-213. (Pubitemid 33712825)
7. Ma PX, Zhang R, Xiao G, Franceschi R. Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001;54:284-293.
8. Naughton GK, Tolbert WR, Grillot TM. Emerging developments in tissue engineering and cell technology. Tissue Eng 1995;2:211-219.
9. Burg KJL, Porter S, Kellam JF. Biomaterial developments for bone tissue engineering. Biomaterials 2000;21:2347-2359.
10. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543.
11. Li CM, Vepari C, Jin HJ, Kim HJ, Kaplan DL. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 2006;27:3115-3124. (Pubitemid 43247585)
12. Ren L, Tsuru K, Hayakawa S, Osaka A. Novel approach to fabricate porous gelatin-siloxane hybrids for bone tissue engineering. Biomaterials 2002;23:4765-4773. (Pubitemid 35286697)
13. Borden M, Attawia M, Laurencin CT. The sintered microshpere matrix for bone tissue engineering: In vitro osteoconductivity studies. J Biomed Mater Res 2002;61:421-429.
14. Whang K, Thomas CH, Healy KE, Nuber G. A novel method to fabricate bioabsorbable scaffolds. Polymer 1995;36:837-842.
15. Kim HJ, Kim U-J, Gordana V-N, Min B-H, Kaplan DL. Influence of macroporous protein scaffolds on bone tissue engineering from bone marrow stem cells. Biomaterials 2005;26:4442-4452.
16. Peng Q, Weng J, Gu ZW. Manufacturing porous blocks of nano-composite of needle-like hydroxyapatite and chitin for tissue engineering. Key Eng Mater 2005;288-289:199-202. (Pubitemid 46840550)
17. Saito N, Takaoka K. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 2006;24:2287-2293. (Pubitemid 36434047)
18. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopaedic devices. Biomaterials 2000;21:2335-2346.
19. Gunatillak PA, Adhikari R. Biodegradable synthetic polymers for tissue engineering. Eur Cells Mater J 2003;5:1-16. (Pubitemid 38957397)
20. Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 1998;13:94-117. (Pubitemid 128567343)
21. Ohbayashi Y, Miyake M, Nagahata S. A long-term study of implanted artificial hydroxyapatite particles surrounding the carotid artery in adult dogs. Biomaterials 2000;21:501-509. (Pubitemid 30067586)
22. Tas AC, Korkusuz F, Timucin M, Akkas N. An investigation of the chemical synthesis and high temperature sintering behavior of calcium hydroxyaptite (HA) and tricalcium phosphate (TCP) bioceramics. J Mater Sci Mater Med 1997; 8:91-96. (Pubitemid 27104282)
23. Hassna RR, Zhang RM. Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering. Biomaterials 2004;25:5171-5180.
24. Ducheyne P, Qiu Q. Bioactive ceramics: The effect of surface reactivity on bone formation and bone cell function. Biomaterials 1999;20:2287-2303.
25. Gibson LJ. The mechanical behavior of cancellous bone. Biomechanics 1985;18:317-328.
26. Hulbert SF, Morrison SJ, Klawitter JJ. Tissue reaction to three ceramics of porous and non-porous structures. J Biomed Mater Res 1972;6:347-374.
27. Guillemin G, Meunier A, Dallant P, Christel P, Pouliquen JC, Sedel L. Comparison of coral resorption and bone apposition with two natural corals of different porosities. J Biomed Mater Res 1989;23:765-779. (Pubitemid 19148836)
28. Lu JX, Flautre B, Anselme K, Hardouin P, Gallur A, Descamps M, Thierry B. Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci: Mater Med 1999;10:111-120. (Pubitemid 29097627)
29. Mathieu LM, Mueller TL, Bourbana P, Pioletti DP, Müller R, Månson JE. Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering. Biomaterials 2006;27:905-916. (Pubitemid 41484123)
30. Lange FL, Miller KT. Open cell, low density ceramics fabricated from reticulated polymer substrates. Adv Ceram Mater 1987;2:827-831.
31. Rejda BV, Peelen JGJ, de Groot K. Tri calcium phosphate as bone substitute. J Bioeng 1997;1:93-97.
32. Murphy WL, Dennis RG, Kileny JL, Mooney DJ. Salt fusion: An approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng 2002;8:43-52.
33. Gross KA, Rodriguez-Lorenzo LM. Interconnected pore networks from sintered salt particles for scaffolds in tissue engineering applications. J Aust Ceram Soc 2003;39:35-39.
34. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26:5474-5491.
35. Zhang Y, Zhang M. Three dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load bearing bone implants. J Biomed Mater Res 2002;61:1-8. (Pubitemid 34650249)
36. Weng J, Peng Q, Qu SX, Feng B, Lu XY. A method to prepare spherical granules and products of inorganic materials with porous structure. Chinese Patent ZL 200410081399.7.
37. Ramay HR, Zhang M. Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods. Biomaterials 2003;24:3293-3302. (Pubitemid 36581890)
38. Ashok M, Sundaram NM, Kalkura SN. Crystallization of hydroxyapatite at physiological temperature. Mater Lett 2003;57:2066-2070.
39. Hwang K, Lim Y. Chemical and structural changes of hydroxyapatite films by using a sol-gel method. Surface Coat Technol 1999;115:172-175. (Pubitemid 29466645)
40. Mikos AG, Sarakinos G, Lyman MD, Ingber DE, Vacanti JP, Langer R. Prevascularization of porous biodegradable polymers. Biotechnol Bioeng 1993;42:716-723.
41. De Oliverira JF, De Aguiar PF, Rossi AM, Soares GA. Effect of process parameters on the characteristics of porous calcium phosphate ceramics for bone tissue scaffolds. Int Soc Art Org 2003;27:406-411.
42. Gross KA, Rodriguez-Lorenzo LM. Biodegradable composite scaffolds with an interconnected spherical network for bone tissue engineering. Biomaterials 2004;25:4955-4962. (Pubitemid 38523318)
43. Eggli PS, Muller W, Schenk RK. Porous hydroxyapatie and tricalcium phosphate cylinders with 2 different pore-size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution. Clin Orthop Rel Res 1988;232:127-138.
44. Tsuruga E, Takita H, Itoh H, Wakisaka Y, Kuboki Y. Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis. J Biochem 1997;121:317-324. (Pubitemid 27096208)
45. Kuboki Y, Takita H, Kobayashi D, Tsuruga E, Inoue M, Murata M, Nagai N, Dohi Y, Ohgushi H. BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: Topology of osteogenesis. J Biomed Mater Res 1998;39:190-199. (Pubitemid 28060350)
46. Kuboki Y, Jin Q, Takita H. Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis. J Bone Joint Surg Am 2001;83:105-115.
47. Zeltinger J, Sherwood JK, Graham DA, Mueller R, Griggith LG. Effect of pore size and void fraction on cellular adhesion, proliferation and matrix deposition. Tissue Eng 2001;7:557-572. (Pubitemid 33032379)
48. Antikainen T, Ruuskanen M, Taurio R. Polylactide and polyglycolic acid reinforced coralline hydroxyapatite for the reconstruction of cranial bone defects in the rabbit. Acta Neurochir 1992;117:59-62.
49. Gauthier O, Bouler JM, Aguado E, Pilet P. Macroporous biphasic calcium phosphate ceramics: Influence of macropore diameter and macroporosity percentage on bone ingrowth. Biomaterials 1998;19:133-139. (Pubitemid 28239476)