Nuclear factor-κB p50 subunits in chronic periodontitis and Porphyromonas gingivalis lipopolysaccharide-pulsed dendritic cells

Annals of the New York Academy of Sciences

Volumn 1192, Issue , 2010, Pages 278-285

  Jotwani, Ravi ^a   Moonga, Baljit S ^a   Gupta, Siddharth ^a   Cutler, Christopher W ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Dendritic cells; LPS; NF B; P50 p65; Periodontitis; Porphyromonas gingivalis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BLOCKING ANTIBODY; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

CELL MATURATION; CHRONIC PERIODONTITIS; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DNA BINDING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; MONOCYTE; MOUTH MUCOSA; NONHUMAN; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; ARTICLE; BACTEROIDACEAE INFECTION; CASE CONTROL STUDY; CELL CULTURE; CHEMISTRY; DRUG EFFECT; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PULSATILE FLOW;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PORPHYROMONAS GINGIVALIS;

BACTEROIDACEAE INFECTIONS; CASE-CONTROL STUDIES; CELLS, CULTURED; CHRONIC PERIODONTITIS; DENDRITIC CELLS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NF-KAPPA B P50 SUBUNIT; PORPHYROMONAS GINGIVALIS; PULSATILE FLOW; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950633898     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05247.x     Document Type: Conference Paper

References (12)

1. Southerland, J.H. et al. 2006. Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease. Periodontol. 2000 40: 130-143.
2. Muthukuru, M. et al. 2005. Oralmucosal endotoxin tolerance induction in chronic periodontitis. Infect. Immun. 73: 687-694.
3. Carmody, R.J. et al. 2007. Negative regulation of tolllike receptor signaling byNF-kappaB p50 ubiquitination blockade. Science 317: 675-678.
4. Ogawa, T. et al. 2007. Chemical structure and immunobiological activity of Porphyromonas gingivalis lipid A. Front. Biosci. 12: 3795-3812.
5. Gibson, F.C., 3rd et al. 2008. Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis. Front. Biosci. 13: 2041-2059.
6. Krappmann, D. et al. 2004. The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol. Cell Biol. 24: 6488-6500.
7. Baldwin, A.S., Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649-683.
8. Jotwani, R. et al. 2001.Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies. J. Immunol. 167: 4693-4700.
9. Cutler, C.W. et al. 1996. Hemin-induced modifications of the antigenicity and hemin-binding capacity of Porphyromonas gingivalis lipopolysaccharide. Infect. Immun. 64: 2282-2287.
10. Jotwani, R. et al. 2003. Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. Eur. J. Immunol. 33: 2980-2986.
11. Ouaaz, F. et al. 2002. Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity 16: 257-270.
12. Bohuslav, J. et al. 1998. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J. Clin. Invest. 102: 1645-1652.