Risk of pancreatic cancer in chronic hepatitis B virus infection: Data from the REVEAL-HBV cohort study

Liver International

Volumn 30, Issue 3, 2010, Pages 423-429

  Iloeje, Uchenna H ^a   Yang, Hwai I ^b,c   Jen, Chin Lan ^c   Su, Jun ^a   Wang, Li Yu ^d   You, San Lin ^c   Lu, Sheng Nan ^e   Chen, Chien Jen ^b,c  

^a BRISTOL MYERS SQUIBB   (United States)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d MACKAY MEDICAL COLLEGE   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

HBeAg; HBsAg; HBV DNA; Hepatitis B; Pancreatic cancer

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGED; ANTIGEN DETECTION; ARTICLE; CANCER DIAGNOSIS; CANCER INCIDENCE; CANCER REGISTRY; CANCER RISK; COHORT ANALYSIS; DEATH CERTIFICATE; DISEASE ASSOCIATION; DISEASE CARRIER; FEMALE; FOLLOW UP; HAZARD RATIO; HEPATITIS B; HEPATITIS B VIRUS; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; PROPORTIONAL HAZARDS MODEL; RADIOIMMUNOASSAY; RISK ASSESSMENT; SEX DIFFERENCE; TAIWAN;

ADULT; AGED; COHORT STUDIES; DNA, VIRAL; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; RISK FACTORS;

EID: 77950619377     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02147.x     Document Type: Article

References (25)

1. Ries LAG, Hankey BF, Miller BA, Hartman AM, Edwards BK. Cancer Statistics Review 1973-88 1990, Bethesda, MD, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute
2. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide 2004, Lyon, IARC Press
3. Ries LAG, Eisner MP, Kosary CL. SEER Cancer Statistics Review, 1973-1999 2001, Bethesda, MD, National Cancer Institute
4. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet 2004, 363:1049-57.
5. Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev 2003, 27:87-93.
6. Anderson KE, Potter JD, Mack TM. Pancreatic cancer. Cancer Epidemiology and Prevention 1996, 725-71. Schottenfeld D, Fraumeni JF, In, eds, Oxford, Oxford University Press
7. Hohenberger P. Detection of HBs-Ag in the pancreas in cases of pancreatic carcinoma. Hepato-Gastroenterology 1984, 31:239-41.
8. Shimoda T, Shikata T, Karasawa T. Light microscopic localization of hepatitis B virus antigens in the human pancreas. Possibility of multiplication of hepatitis B virus in the human pancreas. Gastroenterology 1981, 81:998-1005.
9. Yoshimura M, Sakurai I, Shimoda T. Detection of HBsAg in the pancreas. Acta Pathol Jpn 1981, 31:711-7.
10. Hoefs JC, Renner IG, Askhcavai M, Redeker AG. Hepatitis B surface antigen in pancreatic and biliary secretions. Gastroenterology 1980, 79:191-4.
11. Hassan MM, Li D, El-Deeb AS. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol 2008, 26:4557-62.
12. Berrington de Gonzalez A, Yun JE, Lee SY, Klein AP, Jee SH. Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study. Cancer Epidemiol Biomarkers Prev 2008, 17:359-64.
13. Yang HI, Su J, Jen CL. Chronic hepatitis B infection in active replication is a risk factor for pancreatic cancer - a long term cohort study. Gastroenterology 2005, 128:A745.
14. Chen CJ, Yang HI, Su J. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006, 295:65-73.
15. Iloeje UH, Yang HI, Su J. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006, 130:678-86.
16. Yang HI, Yeh SH, Chen PJ. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008, 100:1134-43.
17. http://seer.cancer.gov/statfacts/html/pancreas.html, SEER Stat facts Sheets - Cancer of the Pancreas., Available at, (accessed 11 March 2009)
18. Halpern MS, England JM, Deery DT. Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus. Proc Natl Acad Sci USA 1983, 80:4865-9.
19. Halpern MS, Egan J, McMahon SB, Ewert DL. Duck hepatitis B virus is tropic for exocrine cells of the pancreas. Virology 1985, 146:157-61.
20. Tagawa M, Omata M, Yokosuka O. Early events in duck hepatitis B virus infection. Sequential appearance of viral deoxyribonucleic acid in the liver, pancreas, kidney, and spleen. Gastroenterology 1985, 89:1224-9.
21. Halpern MS, McMahon SB, Mason WS, O'Connell AP. Viral antigen expression in the pancreas of DHBV-infected embryos and young ducks. Virology 1986, 150:276-82.
22. Jilbert AR, Freiman JS, Gowans EJ. Duck hepatitis B virus DNA in liver, spleen, and pancreas: analysis by in situ and Southern blot hybridization. Virology 1987, 158:330-8.
23. Freiman JS, Jilbert AR, Dixon RJ. Experimental duck hepatitis B virus infection: pathology and evolution of hepatic and extrahepatic infection. Hepatology 1988, 8:507-13.
24. Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980, 286:533-5.
25. Yu MW, Yeh SH, Chen PJ. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst 2005, 97:265-72.