Multiexponential T2, magnetization transfer, and Quantitative histology in white matter tracts of rat spinal cord

Magnetic Resonance in Medicine

Volumn 63, Issue 4, 2010, Pages 902-909

  Dula, Adrienne N ^a,b   Gochberg, Daniel F ^b   Valentine, Holly L ^b   Valentine, William M ^b   Does, Mark D ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Histology; Magnetization transfer; MRI; Myelin

Indexed keywords

HISTOLOGY; MAGNETIC RESONANCE IMAGING; RATS; VOLUME FRACTION;

AXON DIAMETERS; CONSTANT VOLUMES; MAGNETIZATION TRANSFER; MYELIN; MYELIN WATER FRACTIONS; QUANTITATIVE MRIS; RAT SPINAL CORD; WHITE MATTER TRACTS;

MAGNETIZATION;

MYELIN; WATER; TOLONIUM CHLORIDE;

ANATOMY; ANIMAL TISSUE; ARTICLE; BRAIN REGION; GRAY MATTER; HISTOLOGY; MALE; NERVE FIBER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS; RAT; SPINAL CORD; WHITE MATTER; ANIMAL; IMAGE PROCESSING; METHODOLOGY; MYELINATED NERVE; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NERVE FIBERS, MYELINATED; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TOLONIUM CHLORIDE;

EID: 77950618784     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22267     Document Type: Article

References (41)

1. MacKay A, Whittall K, Adler J, Li D, Paty D, Graeb D. In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 1994; 31: 673-677.
2. Menon RS, Rusinko MS, Allen PS. Proton relaxation studies of water compartmentalization in a model neurological system. Magn Reson Med 1992; 28p264-274.
3. Koenig SH, Brown RD, Spiller M, Lundbom N. Relaxometry of brain: why white matter appears bright in MRI. Magn Reson Med 1990; 14: 482-495.
4. Kucharczyk W, Macdonald PM, Stanisz GJ, Henkelman RM. Relaxivity and magnetization-transfer of white-matter lipids at MR- imaging: importance of cerebrosides and pH. Radiology 1994; 192: 521-529.
5. Gochberg DF, Gore JC. Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times. Magn Reson Med 2007; 57: 437-441.
6. Tozer DJ, Davies GR, Altmann DR, Miller DH, Tofts PS. Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysis. Magn Reson Med 2005; 53: 1415-1422.
7. Stewart WA, MacKay AL, Whittall KP, Moore GR, Paty DW. Spinspin relaxation in experimental allergic encephalomyelitis: analysis of CPMG data using a non-linear least squares method and linear inverse theory. Magn Reson Med 1993; 29: 767-775.
8. Stanisz GJ, Midha R, Munro CA, Henkelman RM. MR properties of rat sciatic nerve following trauma. Magn Reson Med 2001; 45: 415-420.
9. Ou XW, Sun SW, Liang HF, Song SK, Gochberg DF. Quantitative magnetization transfer measured pool-size ratio reflects optic nerve myelin content in ex vivo mice. Magn Reson Med 2009;61:364-371.
10. Laule C, Leung E, Lis DK, Traboulsee AL, Paty DW, MacKay AL, Moore GR. Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology. Mult Scler 2006; 12:747-753.
11. Does MD, Snyder RE. Multiexponential T2 relaxation in degenerating peripheral nerve. Magn Reson Med 1996;35:207-213.
12. Harrison R, Bronskill MJ, Henkelman RM. Magnetization transfer and T2 relaxation components in tissue. Magn Reson Med 1995; 33: 490-496.
13. Does MD, Beaulieu C, Allen PS, Snyder RE. Multi-component T1 relaxation and magnetisation transfer in peripheral nerve. Magn Reson Imaging 1998;16: 1033-1041.
14. Schmierer K, Tozer DJ, Scaravilli F, Altmann DR, Barker GJ, Tofts PS, Miller DH. Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain. J Magn Reson Imaging 2007; 26:41-51. (Pubitemid 47235229)
15. Schmierer K, Wheeler-Kingshott CAM, Tozer DJ, Boulby PA, Parkes HG, Yousry TA, Scaravilli F, Barker GJ, Tofts PS, Miller DH. Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation. Magn Reson Med 2008; 59: 268-277.
16. Odrobina EE, Lam TY, Pun T, Midha R, Stanisz GJ. MR properties of excised neural tissue following experimentally induced demyelination. NMR Biomed 2005; 18:277-284.
17. Chin CL, Wehrli FW, Fan Y, Hwang SN, Schwartz ED, Nissanov J, Hackney DB. Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q-space imaging: simulations and experimental studies. Magn Reson Med 2004; 52: 733-740.
18. Schwartz ED, Chin CL, Shumsky JS, Jawad AF, Brown BK, Wehrli S, Tessler A, Murray M, Hackney DB. Apparent diffusion coefficients in spinal cord transplants and surrounding white matter correlate with degree of axonal dieback after injury in rats. AJNR Am J Neuroradiol 2005;26:7-18.
19. Poon CS, Henkelman RM. Practical T2 quantitation for clinical applications. J Magn Reson Imaging 1992; 2:541-553.
20. Bonny JM, Renou JP, Zanca M. Optimal measurement of magnitude and phase from MR data. J Magn Reson B 1996; 113: 136-144.
21. Whittall KP, MacKay AL. Quantitative interpretation of NMR relaxation data. J Magn Reson 1989; 84:134-152.
22. Golub GH, Heath M, Wahba G. Generalized cross-validation as a method for choosing a good ridge parameter. Technometrics 1979; 21: 215-223.
23. Kozlowski P, Liu J, Yung AC, Tetzlaff W. High-resolution myelin water measurements in rat spinal cord. Magn Reson Med 2008; 59: 796-802.
24. van der Knaap, MS, Valk J, Barkhof F. Magnetic resonance of myelination and myelin disorders. Berlin: Springer; 2005. 1084 p.
25. Smith SA, Golay X, Fatemi A, Mahmood A, Raymond GV, Moser HW, van Zijl PCM, Stanisz GJ. Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy. Magn Reson Med 2009; 61: 22-27.
26. Webb S, Munro CA, Midha R, Stanisz GJ. Is multicomponent T2 a good measure of myelin content in peripheral nerve? Magn Reson Med 2003; 49:638-645.
27. Stanisz GJ, Webb S, Munro CA, Pun T, Midha R. MR properties of excised neural tissue following experimentally induced inflammation. Magn Reson Med 2004; 51: 473-479.
28. Sled JG, Levesque I, Santos AC, Francis SJ, Narayanan S, Brass SD, Arnold DL, Pike GB. Regional variations in normal brain shown by quantitative magnetization transfer imaging. Magn Reson Med 2004; 51:299-303.
29. Levesque I, Pike GB. Characterizing healthy and diseased white matter using quantitative magnetization transfer and multicomponent T2 relaxometry: a unified view via a four-pool model. Magn Reson Med 62:2009. In press.
30. Zimmerman JR, Brittin WE. Nuclear magnetic resonance studies in multiple phase systems: lifetime of a water molecules in an adsorbing phase on silica gel. J Phys Chem 1957; 61: 1328-1333.
31. Andrews TJ, Osborne MT, Does MD. Diffusion of myelin water. Magn Reson Med 2006; 56:381-385.
32. Brownstein KR, Tarr CE. sImportance of classical diffusion in NMR- studies of water in biological cells. Phys Rev A 1979; 19: 2446-2453.
33. Bjarnason TA, Vavasour IM, Chia CL, MacKay AL. Characterization of the NMR behavior of white matter in bovine brain. Magn Reson Med 2005; 54:1072-1081.
34. Moore GR, Leung E, MacKay AL, Vavasour IM, Whittall KP, Cover KS, Li DK, Hashimoto SA, Oger J, Sprinkle TJ, Paty DW. A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain. Neurology 2000; 55:1506-1510.
35. D'Arceuil HE, Westmoreland S, de Crespigny AJ. An approach to high resolution diffusion tensor imaging in fixed primate brain. Neuroimage 2007; 35:553-565.
36. Shepherd TM, Thelwall PE, Stanisz GJ, Blackband SJ. Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue. Magn Reson Med 2009; 62:26-34.
37. Minty EP, Bjarnason TA, Laule C, MacKay AL. Myelin water measurement in the spinal cord. Magn Reson Med 2009; 61: 883-892.
38. Whittall KP, MacKay AL, Graeb DA, Nugent RA, Li DK, Paty DW. In vivo measurement of T2 distributions and water contents in normal human brain. Magn Reson Med 1997; 37: 34-43.
39. Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Fiber composition of the human corpus-callosum. Brain Res 1992; 598:143-153.
40. Stanisz GJ, Kecojevic A, Bronskill MJ, Henkelman RM. Characterizing white matter with magnetization transfer and T (2). Magn Reson Med 1999; 42:1128-1136.
41. Laule C, Vavasour IM, Paty D, Li D, Arnold DL, MacKay A. Correlation between magnetization transfer and myelin water content in normal white matter and MS lesions. Conference Proceedings of the International Society of Magnetic Resonance in Medicine In: Honolulu, HI, 2002.