Non-alcoholic steatohepatitis induces non-fibrosis-related portal hypertension associated with splanchnic vasodilation and signs of a hyperdynamic circulation in vitro and in vivo in a rat model

Liver International

Volumn 30, Issue 3, 2010, Pages 365-375

  Francque, Sven ^a,b   Wamutu, Sam ^b   Chatterjee, Shyama ^b   Van Marck, Eric ^b   Herman, Arnold ^c   Ramon, Albert ^a,d,e   Jung, Alexander ^e   Vermeulen, Wim ^b   De Winter, Benedicte ^b   Pelckmans, Paul ^b   Michielsen, Peter ^b  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d International Tissue Engineering Research Association (ITERA) Life Sciences Forum   (Germany)

^e Genetisch Diagnostisches Labor   (Germany)

Author keywords

Flow measurement; Non alcoholic fatty liver; Portal pressure; Systemic haemodynamics; Vasoconstrictor response

Indexed keywords

CHOLINE; METHIONINE; PHENYLEPHRINE; VASOCONSTRICTOR AGENT;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DOSE RESPONSE; HEMODYNAMICS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIVER BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL DEFICIENCY; PORTAL HYPERTENSION; PORTAL VEIN BLOOD FLOW; PORTAL VEIN BLOOD PRESSURE; RAT; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; VASCULAR RING; VASODILATATION; WISTAR RAT;

ANIMALS; AORTA; BLOOD FLOW VELOCITY; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY LIVER; HEMODYNAMICS; HYPERTENSION, PORTAL; LIVER; LIVER CIRCULATION; MALE; PEROXIDASE; PHENYLEPHRINE; PORTAL PRESSURE; RATS; RATS, WISTAR; SPLANCHNIC CIRCULATION; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 77950611590     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02136.x     Document Type: Article

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