Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact

Journal of Neurotrauma

Volumn 27, Issue 3, 2010, Pages 647-651

  Ochalski, Pawel G ^a   Fellows Mayle, Wendy ^a   Hsieh, Lily B ^a   Srinivas, Ravi ^a   Okonkwo, David O ^a   Dixon, C Edward ^a   Adelson, P David ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b Phoenix Children's Neuroscience Institute   (United States)

Author keywords

Benzodiazepine; Controlled cortical impact; Flumazenil; GABA

Indexed keywords

4 AMINOBUTYRIC ACID; FLUMAZENIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; GABAERGIC SYSTEM; LEARNING; MALE; MAZE TEST; MEMORY; NONHUMAN; RAT;

ANIMALS; BRAIN; BRAIN CHEMISTRY; BRAIN INJURIES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; NOOTROPIC AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, GABA-A; TREATMENT OUTCOME;

EID: 77950608137     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2009.1142     Document Type: Article

References (33)

1. Adelson, P.D., Robichaud, P., Hamilton, R.L., and Kochanek, P.M. (1996). A model of diffuse traumatic brain injury in the immature rat. J. Neurosurg. 85, 877-884.
2. Barker, M.J., Greenwood, K.M., Jackson, M., and Crowe, S.F. (2004). Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 18, 37-48.
3. Diez-Ariza, M., Garcia-Alloza, M., Lasheras, B., Del Rio, J., and Ramirez, M.J. (2002). GABA(A) receptor antagonists enhance cortical acetylcholine release induced by 5-HT(3) receptor blockade in freely moving rats. Brain Res. 956, 81-85.
4. Dixon, C.E., Bao, J., Long, D.A., and Hayes, R.L. (1996). Reduced evoked release of acetylcholine in the rodent hippocampus following traumatic brain injury. Pharmacol. Biochem. Behav. 53, 679-686.
5. Dixon, C.E., Clifton, G.L., Lighthall, J.W., Yaghmai, A.A., and Hayes, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
6. Dixon, C.E., Hamm, R.J., Taft, W.C., and Hayes, R.L. (1994). Increased anticholinergic sensitivity following closed skull impact and controlled cortical impact traumatic brain injury in the rat. J. Neurotrauma 11, 275-287.
7. Dixon, C.E., Liu, S.J., Jenkins, L.W., Bhattachargee, M., Whitson, J.S., Yang, K., and Hayes, R.L. (1995). Time course of increased vulnerability of cholinergic neurotransmission following traumatic brain injury in the rat. Behav. Brain Res. 70, 125-131.
8. Feeney, D.M., and Westerberg, V.S. (1990). Norepinephrine and brain damage: alpha noradrenergic pharmacology alters functional recovery after cortical trauma. Can. J. Psychol. 44, 233-252.
9. File, S.E., and Pellow, S. (1986). Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology (Berl.) 88, 1-11.
10. Giorgetti, M., Bacciottini, L., Giovannini, M.G., Colivicchi, M.A., Goldfarb, J., and Blandina, P. (2000). Local GABAergic modulation of acetylcholine release from the cortex of freely moving rats. Eur. J. Neurosci. 12, 1941-1948. (Pubitemid 30348833)
11. Hamm, R.J., Pike, B.R., Temple, M.D., O'Dell, D.M., and Lyeth, B.G. (1995). The effect of postinjury kindled seizures on cognitive performance of traumatically brain-injured rats. Exp. Neurol. 136, 143-148.
12. Hayes, R.L., Jenkins, L.W., and Lyeth, B.G. (1992). Neurotransmitter- mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids. J. Neurotrauma 9(Suppl.) 1, S173-S187.
13. Imperato, A., Dazzi, L., Obinu, M.C., Gessa, G.L., and Biggio, G. (1993). Inhibition of hippocampal acetylcholine release by benzodiazepines: antagonism by flumazenil. Eur. J. Pharmacol. 238, 135-137.
14. Imperato, A., Dazzi, L., Obinu, M.C., Gessa, G.L., and Biggio, G. (1994). The benzodiazepine receptor antagonist flumazenil increases acetylcholine release in rat hippocampus. Brain Res. 647, 167-171.
15. Jones, T.A., and Schallert, T. (1992). Subcortical deterioration after cortical damage: effects of diazepam and relation to recovery of function. Behav. Brain Res. 51, 1-13.
16. Leonard, C.T. (1994). Motor behavior and neural changes following perinatal and adult-onset brain damage: implications for therapeutic interventions. Phys. Ther. 74, 753-767.
17. Lipton, S.A., and Rosenberg, P.A. (1994). Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
18. Lister, R.G. (1985). The amnesic action of benzodiazepines in man. Neurosci. Biobehav. Rev. 9, 87-94.
19. McNamara, R.K., dePape, G.E., and Skelton, R.W. (1993). Differential effects of benzodiazepine receptor agonists on hippocampal long-term potentiation and spatial learning in the Morris water maze. Brain Res. 626, 63-70.
20. McNamara, R.K., and Skelton, R.W. (1992). Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze. Pharmacol. Biochem. Behav. 41, 529-538.
21. Moor, E., DeBoer, P., and Westerink, B.H. (1998). GABA receptors and benzodiazepine binding sites modulate hippocampal acetylcholine release in vivo. Eur. J. Pharmacol. 359, 119-126.
22. Murdoch, I., Perry, E.K., Court, J.A., Graham, D.I., and Dewar, D. (1998). Cortical cholinergic dysfunction after human head injury. J. Neurotrauma 15, 295-305.
23. Mysiw, W.J., Bogner, J.A., Corrigan, J.D., Fugate, L.P., Clinchot, D.M., and Kadyan, V. (2006). The impact of acute care medications on rehabilitation outcome after traumatic brain injury. Brain Inj. 20, 905-911.
24. Nutt, D.J., Cowen, P.J., and Little, H.J. (1982). Unusual interactions of benzodiazepine receptor antagonists. Nature 295, 436-438.
25. O'Dell, D.M., Gibson, C.J., Wilson, M.S., DeFord, S.M., and Hamm, R.J. (2000). Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats. Brain Res. 861, 325-332.
26. O'Dell, D.M., and R.J. Hamm (1995). Chronic postinjury administration of MDL 26,479 (suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J. Neurosurg. 83, 878-883.
27. Ochalski, P.G., Okonkwo, D.O., Bell, M.J., and Adelson, P.D. (2009). Reversal of sedation with flumazenil in a child after traumatic brain injury. J. Neurosurg. Pediatr. 3, 240-243.
28. Prins, M.L., and Hovda, D.A. (1998). Traumatic brain injury in the developing rat: effects of maturation on Morris water maze acquisition. J. Neurotrauma 15, 799-811.
29. Prins, M.L., and Hovda, D.A. (2003). Developing experimental models to address traumatic brain injury in children. J. Neurotrauma 20, 123-137.
30. Savic, M.M., Obradovic, D.I., Ugresic, N.D., Cook, J.M., Yin, W., and Bokonjic, D.R. (2004). Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt. Pharmacol. Biochem. Behav. 79, 279-290.
31. Schallert, T., Hernandez, T.D., and Barth, T.M. (1986). Recovery of function after brain damage: severe and chronic disruption by diazepam. Brain Res. 379, 104-111.
32. Schmidt, R.H., and Grady, M.S. (1995). Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury. J. Neurosurg. 83, 496-502.
33. Weiss, M., Tikhonov, D., and Buldakova, S. (2002). Effect of flumazenil on GABAA receptors in isolated rat hippocampal neurons. Neurochem. Res. 27, 1605-1612.