The epidemiology of childhood stroke

European Journal of Paediatric Neurology

Volumn 14, Issue 3, 2010, Pages 197-205

  Mallick, Andrew A ^a   O'Callaghan, Finbar J K ^a  

^a Academic Unit of Child Health   (United Kingdom)

Author keywords

Child; Epidemiology; Incidence; Mortality; Stroke

Indexed keywords

AGE DISTRIBUTION; CHILD; CHILDHOOD MORTALITY; CHILDHOOD STROKE; EPIDEMIOLOGICAL DATA; ETHNICITY; GEOGRAPHIC DISTRIBUTION; HUMAN; PRIORITY JOURNAL; REVIEW; SEX DETERMINATION; STROKE;

AGE DISTRIBUTION; CHILD, PRESCHOOL; CONTINENTAL POPULATION GROUPS; DEVELOPED COUNTRIES; EPIDEMIOLOGIC STUDIES; GEOGRAPHY; HUMANS; INCIDENCE; INFANT; INFANT MORTALITY; INFANT, NEWBORN; MORTALITY; RISK FACTORS; SEX DISTRIBUTION; STROKE;

EID: 77950594997     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2009.09.006     Document Type: Review

References (92)

1. Aho K., Harmsen P., Hatano S., Marquardsen J., Smirnov V.E., and Strasser T. Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ 58 (1980) 113-130
2. Sudlow C.L., and Warlow C.P. Comparing stroke incidence worldwide: what makes studies comparable?. Stroke 27 (1996) 550-558
3. WHO. The global burden of disease 2004 update (2008), WHO, Geneva
4. Warlow C.P. Epidemiology of stroke. Lancet 352 Suppl. 3 (1998) SIII1-SIII4
5. Feigin V.L., Lawes C.M., Bennett D.A., and Anderson C.S. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2 (2003) 43-53
6. Johnston S.C., Mendis S., and Mathers C.D. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. Lancet Neurol 8 (2009) 345-354
7. Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., et al. Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117 (2008) e25-e146
8. Ganesan V., Hogan A., Shack N., Gordon A., Isaacs E., and Kirkham F.J. Outcome after ischaemic stroke in childhood. Dev Med Child Neurol 42 (2000) 455-461
9. Lo W., Zamel K., Ponnappa K., Allen A., Chisolm D., Tang M., et al. The cost of pediatric stroke care and rehabilitation. Stroke 39 (2008) 161-165
10. Earley C.J., Kittner S.J., Feeser B.R., Gardner J., Epstein A., Wozniak M.A., et al. Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study. Neurology 51 (1998) 169-176
11. Giroud M., Lemesle M., Gouyon J.B., Nivelon J.L., Milan C., and Dumas R. Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: a study of incidence and clinical features from 1985 to 1993. J Clin Epidemiol 48 (1995) 1343-1348
12. Satoh S., Shirane R., and Yoshimoto T. Clinical survey of ischemic cerebrovascular disease in children in a district of Japan. Stroke 22 (1991) 586-589
13. Fullerton H.J., Wu Y.W., Zhao S., and Johnston S.C. Risk of stroke in children: ethnic and gender disparities. Neurology 61 (2003) 189-194
14. deVeber G., Andrew M., Adams C., Bjornson B., Booth F., Buckley D.J., et al. Cerebral sinovenous thrombosis in children. N Engl J Med 345 (2001) 417-423
15. Chung B., and Wong V. Pediatric stroke among Hong Kong Chinese subjects. Pediatrics 114 (2004) e206-e212
16. Kirkham F.J., Williams A.N., Aylett S., and Ganesan V. Cerebrovascular disease/stroke and like illness. British Paediatric Surveillance Unit, 17th annual report (2003), Royal College of Paediatrics and Child Health, London 10-12
17. Steinlin M., Pfister I., Pavlovic J., Everts R., Boltshauser E., Capone Mori A., et al. The first three years of the Swiss Neuropaediatric Stroke Registry (SNPSR): a population-based study of incidence, symptoms and risk factors. Neuropediatrics 36 (2005) 90-97
18. deVeber G. The Canadian Pediatric Ischemic Stroke Study Group: Canadian Paediatric Ischemic Stroke Registry: analysis of children with arterial ischemic stroke. [abstract]. Ann Neurol 48 (2000) 514
19. Gudmundsson G., and Benedikz J.E. Epidemiological investigation of cerebrovascular disease in Iceland, 1958-1968 (ages 0-35 years): a total population survey. Stroke 8 (1977) 329-331
20. Kleindorfer D., Khoury J., Kissela B., Alwell K., Woo D., Miller R., et al. Temporal trends in the incidence and case fatality of stroke in children and adolescents. J Child Neurol 21 (2006) 415-418
21. Gabis L.V., Yangala R., and Lenn N.J. Time lag to diagnosis of stroke in children. Pediatrics 110 (2002) 924-928
22. McGlennan C., and Ganesan V. Delays in investigation and management of acute arterial ischaemic stroke in children. Dev Med Child Neurol 50 (2008) 537-540
23. Rafay M.F., Pontigon A.M., Chiang J., Adams M., Jarvis D.A., Silver F., et al. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke 40 (2009) 58-64
24. Meyer-Heim A.D., and Boltshauser E. Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain Dev 25 (2003) 416-421
25. Braun K.P., Kappelle L.J., Kirkham F.J., and Deveber G. Diagnostic pitfalls in paediatric ischaemic stroke. Dev Med Child Neurol 48 (2006) 985-990
26. Silman A.J. Studies of disease occurrence. Epidemiological studies: a practical guide (1995), Cambridge University Press, Cambridge 29-33
27. Eeg-Olofsson O., and Ringheim Y. Stroke in children. Clinical characteristics and prognosis. Acta Paediatr Scand 72 (1983) 391-395
28. Schoenberg B.S., Mellinger J.F., and Schoenberg D.G. Cerebrovascular disease in infants and children: a study of incidence, clinical features, and survival. Neurology 28 (1978) 763-768
29. National Center for Health Statistics. Health, United States, 2007, with chartbook on trends in the health of Americans; 2007. p. 221.
30. Fullerton H.J., Chetkovich D.M., Wu Y.W., Smith W.S., and Johnston S.C. Deaths from stroke in US children, 1979 to 1998. Neurology 59 (2002) 34-39
31. Mallick AA, Ganesan V, O'Callaghan FJK. Mortality from childhood stroke in England and Wales, 1921-2000. Arch Dis Child, in press, doi:10.1136/adc.2008.156109.
32. Barnes C., Newall F., Furmedge J., Mackay M., and Monagle P. Arterial ischaemic stroke in children. J Paediatr Child Health 40 (2004) 384-387
33. Charlton J., Murphy M.E., Khaw K.T., Ebrahim S.B., and Davey Smith G. Cardiovascular diseases. In: Charlton J., and Murphy M.E. (Eds). The health of adult Britain 1841-1994 vol. 2 (1997), The Stationery Office, London 60-75
34. deVeber G., Roach E.S., Riela A.R., and Wiznitzer M. Stroke in children: recognition, treatment, and future directions. Semin Pediatr Neurol 7 (2000) 309-317
35. Raju T.N., Nelson K.B., Ferriero D., and Lynch J.K. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics 120 (2007) 609-616
36. Laugesaar R., Kolk A., Tomberg T., Metsvaht T., Lintrop M., Varendi H., et al. Acutely and retrospectively diagnosed perinatal stroke: a population-based study. Stroke 38 (2007) 2234-2240
37. Rosenstein N.E., Perkins B.A., Stephens D.S., Lefkowitz L., Cartter M.L., Danila R., et al. The changing epidemiology of meningococcal disease in the United States, 1992-1996. J Infect Dis 180 (1999) 1894-1901
38. Hauser W.A., Annegers J.F., and Kurland L.T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34 (1993) 453-468
39. O'Callaghan F.J., Osmond C., and Martyn C.N. Trends in epilepsy mortality in England and Wales and the United States, 1950-1994. Am J Epidemiol 151 (2000) 182-189
40. Warner D.P., McKinney P.A., Law G.R., and Bodansky H.J. Mortality and diabetes from a population based register in Yorkshire 1978-93. Arch Dis Child 78 (1998) 435-438
41. Sebire G., Meyer L., and Chabrier S. Varicella as a risk factor for cerebral infarction in childhood: a case-control study. Ann Neurol 45 (1999) 679-680
42. Askalan R., Laughlin S., Mayank S., Chan A., MacGregor D., Andrew M., et al. Chickenpox and stroke in childhood: a study of frequency and causation. Stroke 32 (2001) 1257-1262
43. Braun K.P., Bulder M.M., Chabrier S., Kirkham F.J., Uiterwaal C.S., Tardieu M., et al. The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke. Brain 132 (2009) 544-557
44. Finger R., Hughes J.P., Meade B.J., Pelletier A.R., and Palmer C.T. Age-specific incidence of chickenpox. Public Health Rep 109 (1994) 750-755
45. de Melker H., Berbers G., Hahne S., Rumke H., van den Hof S., de Wit A., et al. The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination. Vaccine 24 (2006) 3946-3952
46. Vyse A.J., Gay N.J., Hesketh L.M., Morgan-Capner P., and Miller E. Seroprevalence of antibody to varicella zoster virus in England and Wales in children and young adults. Epidemiol Infect 132 (2004) 1129-1134
47. Carandang R., Seshadri S., Beiser A., Kelly-Hayes M., Kase C.S., Kannel W.B., et al. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA 296 (2006) 2939-2946
48. Petrea R.E., Beiser A.S., Seshadri S., Kelly-Hayes M., Kase C.S., and Wolf P.A. Gender differences in stroke incidence and poststroke disability in the Framingham Heart Study. Stroke 40 (2009) 1032-1037
49. Zahuranec D.B., Brown D.L., Lisabeth L.D., and Morgenstern L.B. Is it time for a large, collaborative study of pediatric stroke?. Stroke 36 (2005) 1825-1829
50. Golomb M.R., Fullerton H.J., Nowak-Gottl U., and Deveber G. Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke 40 (2009) 52-57
51. Roquer J., Campello A.R., and Gomis M. Sex differences in first-ever acute stroke. Stroke 34 (2003) 1581-1585
52. Reeves M.J., Bushnell C.D., Howard G., Gargano J.W., Duncan P.W., Lynch G., et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol 7 (2008) 915-926
53. Janfaza M., Sherman T.I., Larmore K.A., Brown-Dawson J., and Klein K.O. Estradiol levels and secretory dynamics in normal girls and boys as determined by an ultrasensitive bioassay: a 10 year experience. J Pediatr Endocrinol Metab 19 (2006) 901-909
54. Alonso L.C., and Rosenfield R.L. Oestrogens and puberty. Best Pract Res Clin Endocrinol Metab 16 (2002) 13-30
55. Du L., Bayir H., Lai Y., Zhang X., Kochanek P.M., Watkins S.C., et al. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem 279 (2004) 38563-38570
56. Liu M., Hurn P.D., Roselli C.E., and Alkayed N.J. Role of P450 aromatase in sex-specific astrocytic cell death. J Cereb Blood Flow Metab 27 (2007) 135-141
57. Benedict S., and Bale J. Members of the IPSS. Arterial dissection in childhood stroke: results from the International Pediatric Stroke Study (IPSS). Ann Neurol 62 (2007) S98
58. Ganesan V., Prengler M., McShane M.A., Wade A.M., and Kirkham F.J. Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol 53 (2003) 167-173
59. Fullerton H.J., Johnston S.C., and Smith W.S. Arterial dissection and stroke in children. Neurology 57 (2001) 1155-1160
60. Obama M.T., Dongmo L., Nkemayim C., Mbede J., and Hagbe P. Stroke in children in Yaounde, Cameroon. Indian Pediatr 31 (1994) 791-795
61. Shi K.L., Wang J.J., Li J.W., Jiang L.Q., Mix E., Fang F., et al. Arterial ischemic stroke: experience in Chinese children. Pediatr Neurol 38 (2008) 186-190
62. Rasul C.H., Mahboob A.A., Hossain S.M., and Ahmed K.U. Predisposing factors and outcome of stroke in childhood. Indian Pediatr 46 (2009) 419-421
63. Mackay M.T., and Gordon A. Stroke in children. Aust Fam Physician 36 (2007) 896-902
64. Jordan L.C. Stroke in childhood. Neurologist 12 (2006) 94-102
65. Salih M.A., Abdel-Gader A.G., Al-Jarallah A.A., Kentab A.Y., Alorainy I.A., Hassan H.H., et al. Stroke in Saudi children. Epidemiology, clinical features and risk factors. Saudi Med J 27 Suppl. 1 (2006) S12-S20
66. Lee Y.Y., Lin K.L., Wang H.S., Chou M.L., Hung P.C., Hsieh M.Y., et al. Risk factors and outcomes of childhood ischemic stroke in Taiwan. Brain Dev 30 (2008) 14-19
67. Ranzan J., and Rotta N.T. Ischemic stroke in children: a study of the associated alterations. Arq Neuropsiquiatr 62 (2004) 618-625
68. Strater R., Becker S., von Eckardstein A., Heinecke A., Gutsche S., Junker R., et al. Prospective assessment of risk factors for recurrent stroke during childhood - a 5-year follow-up study. Lancet 360 (2002) 1540-1545
69. Fullerton H.J., Wu Y.W., Sidney S., and Johnston S.C. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging. Pediatrics 119 (2007) 495-501
70. Amlie-Lefond C., Bernard T.J., Sebire G., Friedman N.R., Heyer G.L., Lerner N.B., et al. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study. Circulation 119 (2009) 1417-1423
71. Gillum R.F. Stroke mortality in blacks. Disturbing trends. Stroke 30 (1999) 1711-1715
72. Qureshi A.I., Suri M.F., Guterman L.R., and Hopkins L.N. Ineffective secondary prevention in survivors of cardiovascular events in the US population: report from the Third National Health and Nutrition Examination Survey. Arch Intern Med 161 (2001) 1621-1628
73. Kleindorfer D. Sociodemographic groups at risk: race/ethnicity. Stroke 40 (2009) S75-S78
74. Howard T.D., Giles W.H., Xu J., Wozniak M.A., Malarcher A.M., Lange L.A., et al. Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women. Stroke 36 (2005) 1848-1851
75. Pappachan J., and Kirkham F.J. Cerebrovascular disease and stroke. Arch Dis Child 93 (2008) 890-898
76. Strong C. Is stroke in children on the rise? What can be done?. Neurol Rev 10 12 (2002)
77. Lynch J.K., Hirtz D.G., DeVeber G., and Nelson K.B. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109 (2002) 116-123
78. Broderick J., Talbot G.T., Prenger E., Leach A., and Brott T. Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage. J Child Neurol 8 (1993) 250-255
79. Sofronas M., Ichord R.N., Fullerton H.J., Lynch J.K., Massicotte M.P., Willan A.R., et al. Pediatric stroke initiatives and preliminary studies: what is known and what is needed?. Pediatr Neurol 34 (2006) 439-445
80. Roach E.S., and Riela A.R. Pediatric cerebrovascular disorders. 2nd ed. (1995), Futura, Armonk, NY
81. Lynch J.K. Cerebrovascular disorders in children. Curr Neurol Neurosci Rep 4 (2004) 129-138
82. Tan P.L., King D., Durkin C.J., Meagher T.M., and Briley D. Diffusion weighted magnetic resonance imaging for acute stroke: practical and popular. Postgrad Med J 82 (2006) 289-292
83. Shellhaas R.A., Smith S.E., O'Tool E., Licht D.J., and Ichord R.N. Mimics of childhood stroke: characteristics of a prospective cohort. Pediatrics 118 (2006) 704-709
84. Fogle C.C., Oser C.S., Troutman T.P., McNamara M., Williamson A.P., Keller M., et al. Public education strategies to increase awareness of stroke warning signs and the need to call 911. J Public Health Manag Pract 14 (2008) e17-e22
85. Department of Health (UK). Stroke: Act F.A.S.T. awareness campaign (2009). http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/DH_094239 [accessed 06.09.2009]
86. Mallick A.A., and Ganesan V. Arterial ischemic stroke in children - recent advances. Indian J Pediatr 75 (2008) 1149-1157
87. National Center for Biotechnology Information. PubMed home (2009). http://www.ncbi.nlm.nih.gov/pubmed [accessed 07.09.09]
88. Mazumdar M., Heeney M.M., Sox C.M., and Lieu T.A. Preventing stroke among children with sickle cell anemia: an analysis of strategies that involve transcranial Doppler testing and chronic transfusion. Pediatrics 120 (2007) e1107-e1116
89. Silman A.J. Introductory epidemiological data analysis. Epidemiological studies: a practical guide (1995), Cambridge University Press, Cambridge 29-33
90. Al-Rajeh S., Larbi E.B., Bademosi O., Awada A., Yousef A., al-Freihi H., et al. Stroke register: experience from the eastern province of Saudi Arabia. Cerebrovasc Dis 8 (1998) 86-89
91. Beran-Koehn M.A., Brown R.D., Mellinger J.F., Christianson T.J., and O'Fallon W.M. Cerebrovascular disease in children: incidence, etiology and outcome [abstract]. Neurology 52 Suppl. 2 (1999) A43-A44
92. Ghandehari K., and Izadi-Mood Z. Incidence and etiology of pediatric stroke in Southern Khorasan. ARYA Atherosclerosis J 3 (2007) 29-33