Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and β-catenin, Sox9, and osteocalcin immunostaining of 22 cases

Human Pathology

Volumn 41, Issue 5, 2010, Pages 653-662

  Fanburg Smith, Julie C ^a   Auerbach, Aaron ^a   Marwaha, Jayson S ^a   Wang, Zengfeng ^a   Rushing, Elisabeth J ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

Catenin; Chondrogenesis; Endochondral ossification; Mesenchymal chondrosarcoma; Metaplastic cartilage; Osteocalcin; Sox9

Indexed keywords

BETA CATENIN; OSTEOCALCIN; TRANSCRIPTION FACTOR SOX9;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER MORPHOLOGY; CANCER SIZE; CARTILAGE CELL; CELL DEATH; CELL STRUCTURE; CHILD; CHONDROSARCOMA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; FEMALE; FOLLOW UP; GROWTH PLATE; HUMAN; HUMAN TISSUE; HYALINE CARTILAGE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOSARCOMA; PROTEIN EXPRESSION; SCHOOL CHILD; TUMOR BIOPSY;

ADOLESCENT; ADULT; AGED; BETA CATENIN; BONE AND BONES; BONE NEOPLASMS; BRAIN NEOPLASMS; CHILD; CHONDROCYTES; CHONDROSARCOMA, MESENCHYMAL; FEMALE; HUMANS; HYALINE CARTILAGE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; OSSIFICATION, HETEROTOPIC; OSTEOBLASTS; OSTEOCALCIN; SOX9 TRANSCRIPTION FACTOR;

EID: 77950594065     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.11.006     Document Type: Article

References (35)

1. Dantonello T.M., Int-Veen C., Leuschner I., et al. Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer 112 (2008) 2424-2431
2. Nakashima Y., Unni K.K., Shives T.C., Swee R.G., and Dahlin D.C. Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 57 (1986) 2444-2453
3. De C.R., Migliaccio I., Falleti J., Del Basso De C.M., and Pettinato G. Congenital intracranial mesenchymal chondrosarcoma: case report and review of the literature in pediatric patients. Pediatr Dev Pathol 11 (2008) 309-313
4. Salvador A.H., Beabout J.W., and Dahlin D.C. Mesenchymal chondrosarcoma-observations on 30 new cases. Cancer 28 (1971) 605-615
5. Guccion J.G., Font R.L., Enzinger F.M., and Zimmerman L.E. Extraskeletal mesenchymal chondrosarcoma. Arch Pathol 95 (1973) 336-340
6. Lockhart R., Menard P., Martin J.P., Auriol M., Vaillant J.M., and Bertrand J.C. Mesenchymal chondrosarcoma of the jaws. Report of four cases. Int J Oral Maxillofac Surg 27 (1998) 358-362
7. Vencio E.F., Reeve C.M., Unni K.K., and Nascimento A.G. Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. Cancer 82 (1998) 2350-2355
8. Rushing E.J., Armonda R.A., Ansari Q., and Mena H. Mesenchymal chondrosarcoma: a clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system. Cancer 77 (1996) 1884-1891
9. Salvati M., Caroli E., Frati A., et al. Central nervous system mesenchymal chondrosarcoma. J Exp Clin Cancer Res 24 (2005) 317-324
10. Scheithauer B.W., and Rubinstein L.J. Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. Cancer 42 (1978) 2744-2752
11. Fletcher C.D., and Krausz T. Cartilaginous tumours of soft tissue. Appl Pathol 6 (1988) 208-220
12. Lefebvre V. Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol 16 (1998) 529-540
13. Soderstrom M., Bohling T., Ekfors T., Nelimarkka L., Aro H.T., and Vuorio E. Molecular profiling of human chondrosarcomas for matrix production and cancer markers. Int J Cancer 100 (2002) 144-151
14. Wehrli B.M., Huang W., de C.B., Ayala A.G., and Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol 34 (2003) 263-269
15. Akiyama H., Lyons J.P., Mori-Akiyama Y., et al. Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev 18 (2004) 1072-1087
16. Yano F., Kugimiya F., Ohba S., et al. The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun 333 (2005) 1300-1308
17. Ng T.L., Gown A.M., Barry T.S., et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol 18 (2005) 68-74
18. Fanburg J.C., Rosenberg A.E., Weaver D.L., et al. Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. Am J Clin Pathol 108 (1997) 464-473
19. Fanburg-Smith J.C., Bratthauer G.L., and Miettinen M. Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. Hum Pathol 30 (1999) 32-38
20. Hsu S.M., Raine L., and Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29 (1981) 577-580
21. de Crombrugghe B., Lefebvre V., and Nakashima K. Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol 13 (2001) 721-727
22. Lightenstein L., and Bernstein D. Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas. Cancer 12 (1959) 1142-1157
23. Dabska M., and Huvos A.G. Mesenchymal chondrosarcoma in the young. Virchows Arch A Pathol Anat Histopathol 399 (1983) 89-104
24. Aigner T., Loos S., Muller S., Sandell L.J., Unni K.K., and Kirchner T. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. Am J Pathol 156 (2000) 1327-1335
25. Ushigome S., Takakuwa T., Shinagawa T., Takagi M., Kishimoto H., and Mori N. Ultrastructure of cartilaginous tumors and S-100 protein in the tumors. With reference to the histogenesis of chondroblastoma, chondromyxoid fibroma and mesenchymal chondrosarcoma. Acta Pathol Jpn 34 (1984) 1285-1300
26. Hoang M.P., Suarez P.A., Donner L.R., et al. Mesenchymal chondrosarcoma: a small cell neoplasm with polyphenotypic differentiation. Int J Surg Pathol 8 (2000) 291-301
27. Swanson P.E., Lillemoe T.J., Manivel J.C., and Wick M.R. Mesenchymal chondrosarcoma. An immunohistochemical study. Arch Pathol Lab Med 114 (1990) 943-948
28. Lefebvre V., Huang W., Harley V.R., Goodfellow P.N., and de C.B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 17 (1997) 2336-2346
29. Kulyk W.M., Franklin J.L., and Hoffman L.M. Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme. Exp Cell Res 255 (2000) 327-332
30. Bi W., Deng J.M., Zhang Z., Behringer R.R., and de C.B. Sox9 is required for cartilage formation. Nat Genet 22 (1999) 85-89
31. Mau E., Whetstone H., Yu C., Hopyan S., Wunder J.S., and Alman B.A. PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev Biol 305 (2007) 28-39
32. Han Y., and Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol 28 (2008) 4999-5013
33. Issack P.S., Helfet D.L., and Lane J.M. Role of Wnt signaling in bone remodeling and repair. HSSJ 4 (2008) 66-70
34. Topol L., Chen W., Song H., Day T.F., and Yang Y. Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol 284 (2009) 3323-3333
35. Hill T.P., Spater D., Taketo M.M., Birchmeier W., and Hartmann C. Canonical Wnt/betacatenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cel 8 (2005) 727-738