Hypoxic cutaneous vasodilation is sustained during brief cold stress and is not affected by changes in CO2

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 788-792

  Simmons, Grant H ^a   Fieger, Sarah M ^a   Minson, Christopher T ^a   Halliwill, John R ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

Hypoxia; Skin

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; CELL HYPOXIA; COLD; HEMODYNAMICS; HUMAN; HYPERCAPNIA; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SKIN; VASCULARIZATION; VASODILATATION;

ADULT; BLOOD FLOW VELOCITY; CARBON DIOXIDE; CELL HYPOXIA; COLD TEMPERATURE; HEMODYNAMICS; HUMANS; HYPERCAPNIA; MALE; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; SKIN; STRESS, PHYSIOLOGICAL; VASODILATION; YOUNG ADULT;

EID: 77950579000     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01221.2009     Document Type: Article

References (26)

1. 2 elimination. Undersea Biomed Res 18: 279-292, 1991.
2. Anholm JD, Powles AC, Downey R, 3rd Houston CS, Sutton JR, Bonnet MH, Cymerman A. Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude. Am Rev Respir Dis 145: 817-826, 1992.
3. Black JE, Roddie IC. The mechanism of the changes in forearm vascular resistance during hypoxia. J Physiol 143: 226-235, 1958.
4. Blatteis CM, Lutherer LO. Effect of altitude exposure on thermoregulatory response of man to cold. J Appl Physiol 41: 848-858, 1976.
5. Cipriano LF, Goldman RF. Thermal responses of unclothed men exposed to both cold temperatures and high altitudes. J Appl Physiol, 39: 796-800, 1975.
6. Cooper KE, Edholm OG, Mottram RF. The blood flow in skin and muscle of the human forearm. J Physiol 128: 258-267, 1955.
7. Diji A, Greenfield ADM. The local effect of carbon dioxide on human blood vessels. Am Heart J 60: 907-914, 1960.
8. Halliwill JR, Minson CT. Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans. J Appl Physiol 93: 857-864, 2002.
9. Halliwill JR, Morgan BJ, Charkoudian N. Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans. J Physiol 552: 295-302, 2003.
10. Hamlet MP. Human cold injuries. In: Human Performance Physiology and Environmental Medicine at Terrestrial, Extremes, edited by Pandolf KB, Sawka MN, Gonzalez RR. Traverse City, MI: Cooper Group, 1988, p. 435-466.
11. 11. Hodges GJ, Kosiba WA, Zhao K, Alvarez GE, Johnson JM. The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans. Am J Physiol Heart Circ Physiol 293: H3187-H3192, 2007. (Pubitemid 350106546)
12. Johnson JM, Brengelmann GL, Hales JR, Vanhoutte PM, Wenger CB. Regulation of the cutaneous circulation. Fed Proc 45: 2841-2850, 1986.
13. 13. Johnston CE, White MD, Wu M, Bristow GK, Giesbrecht GG. Eucapnic hypoxia lowers human cold thermoregulatory response thresholds and accelerates core cooling. J Appl Physiol 80: 422-429, 1996. (Pubitemid 26061442)
14. Kollai M. Responses in cutaneous vascular tone to transient hypoxia in man. J Auton Nerv Syst 9: 497-512, 1983.
15. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol Heart Circ Physiol 261: H1659-H1664, 1991.
16. Rowell Human Circulation LB. Regulation During Physical Stress. New York: Oxford Univ. Press, 1986.
17. 17. Sagawa S, Shiraki K, Konda N. Cutaneous vascular responses to heat simulated at a high altitude of 5,600 m. J Appl Physiol 60: 1150-1154, 1986. (Pubitemid 16028409)
18. Saito M, Mano T, Iwase S, Koga K, Abe H, Yamazaki Y. Responses in muscle sympathetic activity to acute hypoxia in humans. J Appl Physiol 65: 1548-1552, 1988.
19. Schneider EC, Sisco DL. The circulation of the blood in man at high altitudes. II. The rate of blood flow and the influence of oxygen on the pulse rate and blood flow. Am J Physiol 34: 29-47, 1914.
20. Simmons GH, Minson CT, Cracowski JL, Halliwill JR. Systemic hypoxia causes cutaneous vasodilation in healthy humans. J Appl Physiol, 103: 608-615, 2007.
21. Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67: 2101-2106, 1989.
22. Stein ID, Weinstein I. The value of carbon dioxide baths in the treatment of peripheral vascular disease and allied conditions. Am Heart J 23: 349-361, 1942.
23. 23. Stephens DP, Aoki K, Kosiba WA, Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol, Heart Circ Physiol 280: H1496-H1504, 2001. (Pubitemid 32466182)
24. Thompson CS, Kenney WL. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Physiol 558: 697-704, 2004.
25. Weisbrod CJ, Minson CT, Joyner MJ, Halliwill JR. Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537: 613-621, 2001.
26. 26. West JB, Lahiri S, Maret KH, Peters RM Jr, Pizzo CJ. Barometric pressures at extreme altitudes on Mt Everest: physiological significance. J Appl Physiol 54: 1188-1194, 1983. (Pubitemid 13098962)