Lymphangioleiomyoma cells and lymphatic endothelial cells: Expression of VEGFR-3 in lymphangioleiomyoma cell clusters

American Journal of Pathology

Volumn 176, Issue 4, 2010, Pages 2051-2054

  Seyama, Kuniaki ^a   Mitani, Keiko ^a   Kumasaka, Toshio ^b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPANESE RED CROSS MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; VASCULOTROPIN RECEPTOR 3;

CANCER SURVIVAL; CYTOLOGY; ENDOTHELIUM CELL; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LETTER; LUNG CANCER; LUNG TRANSPLANTATION; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; LYMPHANGIOLEIOMYOMATOSIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

EID: 77950573652     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.091239     Document Type: Letter

References (10)

1. Issaka RB, Oommen S, Gupta SK, Liu G, Myers JL, Ryu JH, Vlahakis NE: Vascular endothelial growth factors C and D induces proliferation of lymphangioleiomyomatosis cells through autocrine crosstalk with endothelium. Am J Pathol 2009, 175:1410-1420
2. Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA Jr, Krymskaya VP: Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem 2002, 277:30958-30967 (Pubitemid 34970798)
3. Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP: Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: role for tumor suppressor TSC2. Am J Respir Cell Mol Biol 2006, 34:561-572
4. Kumasaka T, Seyama K, Mitani K, Sato T, Souma S, Kondo T, Hayashi S, Minami M, Uekusa T, Fukuchi Y, Suda K: Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis. Am J Surg Pathol 2004, 28:1007-1016 (Pubitemid 38971424)
5. Kumasaka T, Seyama K, Mitani K, Souma S, Kashiwagi S, Hebisawa A, Sato T, Kubo H, Gomi K, Shibuya K, Fukuchi Y, Suda K: Lymphangiogenesis- mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. Am J Surg Pathol 2005, 29:1356-1366 (Pubitemid 41368772)
6. Lohela M, Bry M, Tammela T, Alitalo K: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009, 21:154-165
7. Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K: Cytologic, immunocytochemical and ultrastructural characterization of lymphangioleiomyomatosis cell clusters in chylous effusions of patients with lymphangioleiomyomatosis. Acta Cytol 2009, 53:402-409
8. Hayashida M, Seyama K, Inoue Y, Fujimoto K, Kubo K: The epidemiology of lymphangioleiomyomatosis in Japan: a nationwide crosssectional study of presenting features and prognostic factors. Respirology 2007, 12:523-530 (Pubitemid 46961828)
9. Matsui K, Beasley MB, Nelson WK, Barnes PM, Bechtle J, Falk R, Ferrans VJ, Moss J, Travis WD: Prognostic significance of pulmonary lymphangioleiomyomatosis histologic score. Am J Surg Pathol 2001, 25:479-484 (Pubitemid 32240887)
10. Finlay G: The LAM cell: what is it, where does it come from, and why does it grow?. Am J Physiol Lung Cell Mol Physiol 2004, 286:L690-L693