Pathological Findings at Bifurcation Lesions. The Impact of Flow Distribution on Atherosclerosis and Arterial Healing After Stent Implantation

Journal of the American College of Cardiology

Volumn 55, Issue 16, 2010, Pages 1679-1687

  Nakazawa, Gaku ^a   Yazdani, Saami K ^a   Finn, Aloke V ^b   Vorpahl, Marc ^a   Kolodgie, Frank D ^a   Virmani, Renu ^a  

^a CVPATH INSTITUTE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

atherosclerosis; bifurcation; drug eluting stent; flow disturbance

Indexed keywords

FIBRIN;

ADULT; ARTERY INTIMA PROLIFERATION; ARTERY WALL; ARTICLE; ATHEROSCLEROTIC PLAQUE; BARE METAL STENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BIFURCATION; CORONARY ARTERY BLOOD FLOW; CORONARY STENT; DISEASE SEVERITY; DRUG ELUTING STENT; FEMALE; HUMAN; HUMAN TISSUE; IN-STENT RESTENOSIS; INTIMA; MALE; MORPHOMETRICS; PRIORITY JOURNAL; STENT THROMBOSIS;

CADAVER; CORONARY ARTERY DISEASE; CORONARY VESSELS; DRUG-ELUTING STENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; REGENERATION; REGIONAL BLOOD FLOW; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 77950570492     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.01.021     Document Type: Article

References (34)

1. Ku D.N., Giddens D.P., Zarins C.K., and Glagov S. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 5 (1985) 293-302
2. Friedman M.H., Bargeron C.B., Deters O.J., Hutchins G.M., and Mark F.F. Correlation between wall shear and intimal thickness at a coronary artery branch. Atherosclerosis 68 (1987) 27-33
3. Prosi M., Perktold K., Ding Z., and Friedman M.H. Influence of curvature dynamics on pulsatile coronary artery flow in a realistic bifurcation model. J Biomech 37 (2004) 1767-1775
4. Traub O., and Berk B.C. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 18 (1998) 677-685
5. Beohar N., Davidson C.J., Kip K.E., et al. Outcomes and complications associated with off-label and untested use of drug-eluting stents. JAMA 297 (2007) 1992-2000
6. Yamashita T., Nishida T., Adamian M.G., et al. Bifurcation lesions: two stents versus one stent-immediate and follow-up results. J Am Coll Cardiol 35 (2000) 1145-1151
7. Al Suwaidi J., Berger P.B., Rihal C.S., et al. Immediate and long-term outcome of intracoronary stent implantation for true bifurcation lesions. J Am Coll Cardiol 35 (2000) 929-936
8. Iakovou I., Schmidt T., Bonizzoni E., et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 293 (2005) 2126-2130
9. Farb A., Weber D.K., Kolodgie F.D., Burke A.P., and Virmani R. Morphological predictors of restenosis after coronary stenting in humans. Circulation 105 (2002) 2974-2980
10. Joner M., Finn A.V., Farb A., et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48 (2006) 193-202
11. Finn A.V., Joner M., Nakazawa G., et al. Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation 115 (2007) 2435-2441
12. Yazdani S.K., Moore Jr. J.E., Berry J.L., and Vlachos P.P. DPIV measurements of flow disturbances in stented artery models: adverse affects of compliance mismatch. J Biomech Eng 126 (2004) 559-566
13. Liepsch D., Pflugbeil G., Matsuo T., and Lesniak B. Flow visualization and 1- and 3-D laser-Doppler-anemometer measurements in models of human carotid arteries. Clin Hemorheol Microcirc 18 (1998) 1-30
14. Kimura B.J., Russo R.J., Bhargava V., McDaniel M.B., Peterson K.L., and DeMaria A.N. Atheroma morphology and distribution in proximal left anterior descending coronary artery: in vivo observations. J Am Coll Cardiol 27 (1996) 825-831
15. Fox B., James K., Morgan B., and Seed A. Distribution of fatty and fibrous plaques in young human coronary arteries. Atherosclerosis 41 (1982) 337-347
16. Grottum P., Svindland A., and Walloe L. Localization of atherosclerotic lesions in the bifurcation of the main left coronary artery. Atherosclerosis 47 (1983) 55-62
17. Cheng C., van Haperen R., de Waard M., et al. Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. Blood 106 (2005) 3691-3698
18. Cheng C., Tempel D., van Haperen R., et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 113 (2006) 2744-2753
19. Perktold K., Peter R.O., Resch M., and Langs G. Pulsatile non-Newtonian blood flow in three-dimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles. J Biomed Eng 13 (1991) 507-515
20. Richter Y., Groothuis A., Seifert P., and Edelman E.R. Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions. J Clin Invest 113 (2004) 1607-1614
21. Lee S.W., Antiga L., Spence J.D., and Steinman D.A. Geometry of the carotid bifurcation predicts its exposure to disturbed flow. Stroke 39 (2008) 2341-2347
22. Moses J.W., Leon M.B., Popma J.J., et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 349 (2003) 1315-1323
23. Stone G.W., Ellis S.G., Cox D.A., et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med 350 (2004) 221-231
24. Colombo A., Moses J.W., Morice M.C., et al. Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions. Circulation 109 (2004) 1244-1249
25. Park S.J., Kim Y.H., Lee B.K., et al. Sirolimus-eluting stent implantation for unprotected left main coronary artery stenosis: comparison with bare metal stent implantation. J Am Coll Cardiol 45 (2005) 351-356
26. Kim Y.H., Park S.W., Lee S.W., et al. Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease. Circulation 114 (2006) 2148-2153
27. Daemen J., Wenaweser P., Tsuchida K., et al. Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet 369 (2007) 667-678
28. Lagerqvist B., James S.K., Stenestrand U., Lindback J., Nilsson T., and Wallentin L. Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden. N Engl J Med 356 (2007) 1009-1019
29. Stone G.W., Moses J.W., Ellis S.G., et al. Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. N Engl J Med 356 (2007) 998-1008
30. Farb A., and Boam A.B. Stent thrombosis redux-the FDA perspective. N Engl J Med 356 (2007) 984-987
31. Farb A., Burke A.P., Kolodgie F.D., and Virmani R. Pathological mechanisms of fatal late coronary stent thrombosis in humans. Circulation 108 (2003) 1701-1706
32. Brown III C.H., Leverett L.B., Lewis C.W., Alfrey Jr. C.P., and Hellums J.D. Morphological, biochemical, and functional changes in human platelets subjected to shear stress. J Lab Clin Med 86 (1975) 462-471
33. Balakrishnan B., Tzafriri A.R., Seifert P., Groothuis A., Rogers C., and Edelman E.R. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Circulation 111 (2005) 2958-2965
34. Kolachalama V.B., Tzafriri A.R., Arifin D.Y., and Edelman E.R. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release 133 (2009) 24-30