Antitumor-promoting activity of lignans: Inhibition of human cytomegalovirus IE gene expression

Anticancer Research

Volumn 30, Issue 2, 2010, Pages 451-454

  Pusztai, Rozália ^a   Abrantes, Marta ^b   Sherly, Julia ^b   Duarte, Noélia ^b   Molnar, Joseph ^a   Ferreira, Maria José U ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Antitumor promoters; Human cytomegalovirus; Immediate early antigen expression; Lignans

Indexed keywords

3,3',4,4' TETRAMETHOXYLIGNAN; 4' HYDROXY 3,3',4 TRIMETHOXYLIGNAN; 4,4' DIACETYL 3,3' DIMETHOXYLIGNAN; ANTINEOPLASTIC AGENT; DIHYDROCUBEBIN; DIHYDROGUAIARETIC ACID; HELIOBUPHTHALMIN; HINOKININ; LIGNAN; TALAUMIDIN; THREO 4,4' DIHYDROXY 3 METHOXYLIGNAN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOENZYME TECHNIQUES; LIGNANS; LUNG NEOPLASMS; MYRISTICACEAE; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

EID: 77950544499     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Morse MA and Stoner GD: Cancer chemoprevention - principles and prospects. Carcinogenesis 14: 1737-1746, 1993.
2. Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ et al: Progress in chemoprevention drug development: The promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer - A plan to move forward. Clin Cancer Res 12: 3661-3697, 2006.
3. Pan MH and Ho CT: Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev 37: 2558-2574, 2008.
4. Umezawa T: Diversity in lignan biosynthesis. Phytochem Rev 2: 371-390, 2003.
5. Gordaliza M, Castro MA, del Corral JM and Feliciano AS: Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des 6: 1811-1839, 2000.
6. Cos P, Maes L, Vlietinck A and Pieters L: Plant-derived leading compounds for chemotherapy of human immunodefiency virus (HIV) infection - An update (1998-2007). Planta Med 74: 1323-1337, 2008.
7. Jassim SA and Naji MA: Novel antiviral agents: a medicinal plant perspective. J Appl Microbiol 95: 412-427, 2003.
8. Ward RS: Lignans, neolignans and related compounds. Nat Prod Rep 16: 75-96, 1999.
9. Mansoor TA, Ramalho RM, Mulhovo S, Rodrigues CM and Ferreira MJ: Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans. Bioorg Med Chem Lett 19: 4255-4258, 2009.
10. Duarte N, Járdánházy A, Molnár J, Hilgeroth A and Ferreira MJ: Synergistic interaction between P-glycoprotein modulators and epirubicine on resistant cancer cells. Bioorg Med Chem 16: 9323-9330, 2008.
11. Pusztai R, Ferreira MJ, Duarte N, Engi H and Molnar J: Macrocyclic lathyrane diterpenes as antitumor promoters. Anticancer Res 27: 201-205, 2007.
12. Abrantes M, Mil-Homens T, Duarte N, Lopes D, Cravo P, Madureira M and Ferreira MJ: Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis. Planta Med 74: 1408-1412, 2008.
13. Gandhi MK and Khanna R: Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis 4: 725-738, 2004.
14. Mercorelli B, Sinigalia E, Loregian A and Palù G: Human cytomegalovirus DNA replication: antiviral targets and drugs. Rev Med Virol 18: 177-210, 2008.
15. Michaelis M, Kotchetkov R, Vogel JU, Doerr HW and Cinatl J: Cytomegalovirus infection blocks apoptosis in cancer cells. Cell Mol Life Sci 61: 1307-1316, 2004.
16. Michaelis M, Doerr HW and Cinatl J: The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia 11: 1-9, 2009.
17. Scholz M, Doerr HW and Cinatl J: Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option? Antiviral Res 49: 129-145, 2001.