Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 13, 2010, Pages

  Burgdorf, Sven ^a   Schuette, Verena ^a   Semmling, Verena ^a   Hochheiser, Katharina ^a   Lukacs Kornek, Veronika ^b   Knolle, Percy A ^a   Kurts, Christian ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGENASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MANNOSE RECEPTOR; OVALBUMIN;

BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL LYSATE; CELL SUBPOPULATION; CELLULAR IMMUNITY; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENDOCYTOSIS; ENDOSOME; ENZYME DEGRADATION; GEL FILTRATION; HUMAN; INFLAMMATION; INTERNALIZATION; INTRACELLULAR SPACE; LETTER; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SPLEEN CELL; STAINING; STEADY STATE;

ANIMALS; COLLAGEN; CROSS-PRIMING; DENDRITIC CELLS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICE; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, CELL SURFACE;

EID: 77950540195     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000598107     Document Type: Letter

References (5)

1. Burgdorf S, Lukacs-Kornek V, Kurts C (2006) The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol 176:6770-6776.
2. Burgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C (2007) Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316:612-616.
3. Burgdorf S, Schölz C, Kautz A, Tampé R, Kurts C (2008) Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9:558-566.
4. Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA (2009) Different crosspresentation pathways in steady-state and inflammatory dendritic cells. Proc Natl Acad Sci USA 106:20377-20381.
5. Martinez-Pomares L, et al. (2006) Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Eur J Immunol 36:1074-1082.