The fms21 (pilA)-fms20 locus encoding one of four distinct pili of Enterococcus faecium is harboured on a large transferable plasmid associated with gut colonization and virulence

Journal of Medical Microbiology

Volumn 59, Issue 4, 2010, Pages 505-507

  Kim, David S ^a   Singh, Kavindra V ^a   Nallapareddy, Sreedhar R ^a   Qin, Xiang ^b   Panesso, Diana ^a,c   Arias, Cesar A ^a,c   Murray, Barbara E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSIDAD EL BOSQUE   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EBPB PROTEIN; PILA PROTEIN; REPA PROTEIN; UNCLASSIFIED DRUG;

BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BACTERIUM PILUS; CONTROLLED STUDY; ENTEROCOCCUS FAECIUM; GENE CLUSTER; GENE LOCUS; HORIZONTAL GENE TRANSFER; LETTER; NONHUMAN; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; SOUTHERN BLOTTING; STRAIN DIFFERENCE; CHROMOSOME MAP; FIMBRIA; GENETICS; HUMAN; INTESTINE; MICROBIOLOGY; PATHOGENICITY; PULSED FIELD GEL ELECTROPHORESIS; VIRULENCE;

CHROMOSOME MAPPING; ELECTROPHORESIS, GEL, PULSED-FIELD; ENTEROCOCCUS FAECIUM; FIMBRIAE, BACTERIAL; HUMANS; INTESTINES; PLASMIDS; VIRULENCE;

EID: 77950513121     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.016238-0     Document Type: Letter

References (15)

1. Arias, C. A. & Murray, B. E. (2009). Antibiotic-resistant bugs in the 21st century - a clinical super-challenge. N Engl J Med 360, 439-443.
2. Efm- containing virulence plasmid in Enterococcus faecium. Antimicrob Agents Chemother 53, 4240-4246.
3. Barton, B. M., Harding, G. P. & Zuccarelli, A. J. (1995). A general method for detecting and sizing large plasmids. Anal Biochem 226, 235-240.
4. Hendrickx, A. P., van Wamel, W. J., Posthuma, G., Bonten, M. J. & Willems, R. J. (2007). Five genes encoding surface-exposed LPXTG proteins are enriched in hospital-adapted Enterococcus faecium clonal complex 17 isolates. J Bacteriol 189, 8321-8332. (Pubitemid 350178944)
5. Hendrickx, A. P., Bonten, M. J., van Luit-Asbroek, M., Schapendonk, C. M., Kragten, A. H. & Willems, R. J. (2008). Expression of two distinct types of pili by a hospital-acquired Enterococcus faecium isolate. Microbiology 154, 3212-3223.
6. Hidron, A. I., Edwards, J. R., Patel, J., Horan, T. C., Sievert, D. M., Pollock, D. A. & Fridkin, S. K. (2008). NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 29, 996-1011.
7. Nallapareddy, S. R., Singh, K. V., Sillanpaa, J., Garsin, D. A., Hook, M., Erlandsen, S. L. & Murray, B. E. (2006). Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest 116, 2799-2807. (Pubitemid 44511643)
8. Nallapareddy, S. R., Singh, K. V., Okhuysen, P. C. & Murray, B. E. (2008). A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogen. Infect Immun 76, 4110-4119.
9. Efm, predominates in Enterococcus faecium of clinical origin. J Infect Dis 187, 508-512.
10. Rice, L. B., Lakticova, V., Carias, L. L., Rudin, S., Hutton, R. & Marshall, S. H. (2009). Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model. J Infect Dis 199, 342-349.
11. Sillanpaa, J., Nallapareddy, S. R., Prakash, V. P., Qin, X., Hook, M., Weinstock, G. M. & Murray, B. E. (2008). Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology 154, 3199-3211.
12. Sillanpaa, J., Prakash, V. P., Nallapareddy, S. R. & Murray, B. E. (2009). Distribution of genes encoding MSCRAMMs and pili in clinical and natural populations of Enterococcus faecium. J Clin Microbiol 47, 896-901.
13. Singh, K. V., Nallapareddy, S. R. & Murray, B. E. (2007). Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection. J Infect Dis 195, 1671-1677.
14. Top, J., Willems, R. & Bonten, M. (2008). Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogen. FEMS Immunol Med Microbiol 52, 297-308. (Pubitemid 351420752)
15. Willems, R. J., Homan, W., Top, J., van Santen-Verheuvel, M., Tribe, D., Manzioros, X., Gaillard, C., Vandenbroucke-Grauls, C. M., Mascini, E. M. & other authors (2001). Variant esp gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faecium spreading in hospitals. Lancet 357, 853-855. (Pubitemid 32239372)