Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells

Natural Product Communications

Volumn 5, Issue 1, 2010, Pages 103-106

  Nguyen, Manh Cuong ^a   Bui, Huu Tai ^a   Dang, Hoang Hoan ^a   Tran, Thu Huong ^a   Young, Ho Kim ^b   Hyun, Jae Hee ^c   Kang, Hee Kyoung ^c  

^a GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Viet Nam)

^b Chungnam National University   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

Author keywords

HL 60; Indirubin; Indirubin 3 oxime; Leukemia

Indexed keywords

ANTINEOPLASTIC AGENT; INDIRUBIN; INDIRUBIN 3' [O (3 BROMOPROP 1 YL)OXIME]; INDIRUBIN 3' [O (METHOXYCARBONYLMETHYL)OXIME]; INDIRUBIN 3' OXIME; N 1 ACETYLINDIRUBIN; N 1 ACETYLINDIRUBIN 3' ACETOXIME; TRYPAN BLUE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; INDOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; PROMYELOCYTIC LEUKEMIA; CELL STRAIN HL 60; CHEMISTRY;

ANTIBIOTICS, ANTINEOPLASTIC; HL-60 CELLS; HUMANS; INDOLES;

EID: 77950511433     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Ikeda A, Shankar DB, Watanabe M, Tamanoi F, Moore TB, Sakamoto KM. (2006) Molecular targets and the treatment of myeloid leukemia. Molecular Genetics and Metabolism, 88, 216-224. (Pubitemid 43977814)
2. Yang X, Stella MD, Ying X, Leslie LR, Julie AR. (2003) Trends in leukemia incidence and survival in the United States (1973-1998). Cancer, 97, 2229-2235.
3. Wiernik PH. (2001) Adult leukemias, PMPH-USA, New York, pp.3-15.
4. Http://www.cancer.gov/cancertopics/types/leukemia.
5. Laurent M, Nicole G, Leandros AS, Gerhard E. (2006) Indirubin: the red shade of indigo. Life Progress Editions, Roscoff, France, 135-156.
6. Hoessel R, Leclerc S, Endicott JA, Nobel M, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin dependent kinases. Natural Cell Biology, 1, 60-67.
7. Chunrong Y, Mohamed R, Yun D, Daniel C, Geoffrey K, Paul D, Steven G. (2003) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process 1. Cancer Research, 63, 1822-1833.
8. Schnitzer SE, Schmidt T, Zhou J, Eisenbrand G, Brune B. (2005) Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia. FEBS Letters, 79, 529-533.
9. Yuanbin X, Yanling L, Chi M, Zhongmin Y, Wenya W, Zhenyu Z, Guoquan G, Xianguo L, Hengxin Y, Ruzhu C, Shoujian H, Xuelan W, Xiaonan Z, Xuemin W, Zixu M, Mingtao L. (2004) Indirubin-3′-oxime inhibits c-Jun NH2-terminal kinase: anti apoptotic effect in cerebellar granule neurons. Neuroscience Letters, 367, 355-359.
10. Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R. (2005) Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceeding of National Academy of Sciences USA, 102, 5998-6003.
11. Zhen Y, Sorensen V, Jin Y, Suo Z, Wiedlocha A. (2007) Indirubin-3′-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. Oncogene, 26, 3672-3685. (Pubitemid 47494224)
12. Adachi J, Mori Y, Matsui S, Takigami H, Fujino J, Kitagawa H, Miller CA, Kato T, Saeki K, Matsuda T. (2001) Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. Journal of Biological Chemistry, 276, 31475-31478.
13. Suzuki K, Adachi R, Hirayama A, Watanabe H, Otani S, Watanabe Y, Kasahara T. (2005) Indirubin, a Chinese anti-leukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells. British Journal of Haematology, 130, 681-690.
14. 3- and all-trans retinoic acid-induced differentiation of HL-60 leukemia cells. Bioorganic Medicinal Chemistry, 14, 6752-6758.
15. Kagialis-Girard S, Mialou V, Chebel A, Chien WW, Tigaud I, Mokdad F, Badiou C, Ffrench M. (2007) Inhibition of normal lymphocyte proliferation by indirubin-3′-monoxime: a multifactorial process. Leukemia Lymphoma, 48, 605-615.
16. Cuong NM, Thuy DT T, Ha NV, Tai BH. (2007) Isolation of indirubin from the leaves of Strobilanthes cusia. Journal of Science and Technology, 45 (3A), 195-199.
17. BH Tai, DH Hoan, Cuong NM. (2009) Study on the acetylation and NMR reassignment of indirubin derivatives. Natural Product Research, in press.
18. Freshney RI. (1987) Culture of Animal Cells: A Manual of Basic Technique. Alan R. Liss, Inc., New York, USA, p.117.