The impact of early standard therapy on dyspnoea in patients with acute heart failure: The URGENT-dyspnoea study

European Heart Journal

Volumn 31, Issue 7, 2010, Pages 832-841

  Mebazaa, Alexandre ^a   Pang, Peter S ^b   Tavares, Miguel ^a,c   Collins, Sean P ^d   Storrow, Alan B ^e   Laribi, Said ^f   Andre, Stephanie ^a   Mark Courtney, Daniel ^b   Hasa, Jennifer ^g   Spinar, Jindrich ^h   Masip, Josep ⁱ   Frank Peacock, William ^j   Sliwa, Karen ^k   Gayat, Etienne ^a   Filippatos, Gerasimos ^l   Cleland, John G F ^m   Gheorghiade, Mihai ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f HÔPITAL LARIBOISIÈRE   (France)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY HOSPITAL BRNO   (Czech Republic)

ⁱ UNIVERSITY OF BARCELONA   (Spain)

^j LERNER RESEARCH INSTITUTE   (United States)

^k UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^l Soweto Cardiovascular Research Unit CH Baragwanath Hospital University of the Witwatersrand ^*  (Greece)

^m UNIVERSITY OF HULL   (United Kingdom)

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Author keywords

Acute heart failure; Dyspnoea; Orthopnoea

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOBUTAMINE; DOPAMINE; ENOXIMONE; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INOTROPIC AGENT; LEVOSIMENDAN; LOOP DIURETIC AGENT; MILRINONE; NESIRITIDE; NITRATE; NITROPRUSSIDE SODIUM; NORADRENALIN; VASODILATOR AGENT; WARFARIN;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BODY POSITION; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; DISEASE EXACERBATION; DIURETIC THERAPY; DYSPNEA; FEMALE; HEART FAILURE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OXYGEN THERAPY; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROVOCATION TEST; SUPINE POSITION; TREATMENT RESPONSE; VISUAL ANALOG SCALE; BODY POSTURE; CLINICAL TRIAL; EMERGENCY HEALTH SERVICE; HOSPITALIZATION; MIDDLE AGED; MULTICENTER STUDY; PATIENT POSITIONING; VERY ELDERLY;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; DIURETICS; DYSPNEA; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PATIENT POSITIONING; POSTURE; PROSPECTIVE STUDIES;

EID: 77950485827     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp458     Document Type: Article

References (21)

1. Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL. Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 2008;29:2388-2442.
2. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics\2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117:e25-e146.
3. Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, Berkowitz RL, Galvao M, Horton DP. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated HEart Failure National REgistry (ADHERE). Am Heart J 2005; 149:209-216. (Pubitemid 40348525)
4. Gheorghiade M, Filippatos G, De Luca L, Burnett J. Congestion in acute heart failure syndromes: an essential target of evaluation and treatment. Am J Med 2006;119:S3-S10. (Pubitemid 44755377)
5. Committee for Proprietary Medicinal Products (CPMP). Note for guidance on clinical investigation of medicinal products for the treatment of cardiac failure, addendum on acute cardiac failure. London: EMEA, European Medicines Agency; 2004.
6. Teerlink JR. Dyspnea as an end point in clinical trials of therapies for acute decom-pensated heart failure. Am Heart J 2003;145:S26-S33.
7. Cuffe MS, Califf RM, Adams KF Jr, Benza R, Bourge R, Colucci WS, Massie BM, O'Connor CM, Pina I, Quigg R, Silver MA, Gheorghiade M. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 2002;287:1541-1547. (Pubitemid 34269999)
8. Mebazaa A, Nieminen MS, Packer M, Cohen-Solal A, Kleber FX, Pocock SJ, Thakkar R, Padley RJ, Poder P, Kivikko M. Levosimendan vs. dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial. JAMA 2007;297:1883-1891. (Pubitemid 46707842)
9. Packer M. REVIVE II: Multicenter placebo-controlled trial of levosimendan on clinical status in acutely decompensated heart failure (abstract). Dallas, TX: American Heart Association Scientific Sessions 2005 Late Breaking Clinical Trials II; 2005.
10. Gheorghiade M, Konstam MA, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Cook T, Ouyang J, Zimmer C, Orlandi C. Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST clinical status trials. JAMA 2007;297:1332-1343. (Pubitemid 46513234)
11. McMurray JJ, Teerlink JR, Cotter G, Bourge RC, Cleland JG, Jondeau G, Krum H, Metra M, O'Connor CM, Parker JD, Torre-Amione G, van Veldhuisen DJ, Lewsey J, Frey A, Rainisio M, Kobrin I. Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: The VERITAS randomized controlled trials. JAMA 2007;298:2009-2019. (Pubitemid 350074798)
12. VMAC Investigators. Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA 2002;287:1531-1540. (Pubitemid 34269998)
13. Pang PS, Cleland JG, Teerlink JR, Collins SP, Lindsell CJ, Sopko G, Peacock WF, Fonarow GC, Aldeen AZ, Kirk JD, Storrow AB, Tavares M, Mebazaa A, Roland E, Massie BM, Maisel AS, Komajda M, Filippatos G, Gheorghiade M. A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach. Eur Heart J 2008;29:816-824. (Pubitemid 351431028)
14. Yancy CW. Climbing the mountain of acute decompensated heart failure: the EVEREST trials. JAMA 2007;297:1374-1376. (Pubitemid 46513238)
15. Cleland JG, Coletta A, Witte K. Practical applications of intravenous diuretic therapy in decompensated heart failure. Am J Med 2006;119:S26-S36. (Pubitemid 44738817)
16. Peacock WF, Hollander JE, Diercks DB, Lopatin M, Fonarow G, Emerman CL. Morphine and outcomes in acute decompensated heart failure: an ADHERE analysis. Emerg Med J 2008;25:205-209. (Pubitemid 351493056)
17. Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 2002;105: 1348-1353. (Pubitemid 34260427)
18. Coletta A, Cleland J. Clinical trials update: highlights of the scientific sessions of the XXIII Congress of the European Society of Cardiology\WARIS II, ESCAMI, PAFAC, RITZ-1 and TIME. Eur. J. Heart Fail. 2001;3:747-750.
19. Pang PS, Tavares M, Collins SP, Cleland JG, Hollander J, Nieminen M, Miller C, Courtney DM, Kirk JD, Masip J, Parkhomenko A, Macarie C, Peacock WF, Spinar J, Nowak R, Raev D, Storrow AB, Spisak V, Hamdy A, Mebazaa A, Gheorghiade M. Design and rationale of the URGENT dyspnea study: an international, multicenter, prospective study. Am J Ther 2008;15:299-303.
20. Cotter G, Dittrich HC, Weatherley BD, Bloomfield DM, O'Connor CM, Metra M, Massie BM. The protect pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment. J Card Fail 2008;14: 631-640.
21. Teerlink JR, Metra M, Felker GM, Ponikowski P, Voors AA, Weatherley BD, Marmor A, Katz A, Grzybowski J, Unemori E, Teichman SL, Cotter G. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multi-centre, randomised, placebo-controlled, parallel-group, dose-finding Phase IIb study. Lancet 2009;373:1429-1439.