Recommendations for pharmacological management of inpatient aggression in children and adolescents

Psychiatry

Volumn 7, Issue 2, 2010, Pages 32-40

  Deshmukh, Parikshit ^a   Kulkarni, Guarav ^b   Barzman, Drew ^b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Adolescents; Aggression; Antipsychotics; Behavioral; Children; Inpatient; Management; Psychiatric; Ziprasidone

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; CARBAMAZEPINE; DIPHENHYDRAMINE; HALOPERIDOL; LITHIUM; LORAZEPAM; OLANZAPINE; PLACEBO; PSYCHOSTIMULANT AGENT; QUETIAPINE; RISPERIDONE; VALPROATE SEMISODIUM; ZIPRASIDONE;

ADOLESCENT; AGGRESSION; AGITATION; AKATHISIA; ARTICLE; BEHAVIOR DISORDER; BLOOD PRESSURE FLUCTUATION; CHILD; CLINICAL TRIAL; CONDUCT DISORDER; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DROWSINESS; DRUG EFFICACY; DRUG SAFETY; DYSTONIA; GASTROINTESTINAL SYMPTOM; HEART RATE VARIABILITY; HOSPITAL PATIENT; HUMAN; NAUSEA AND VOMITING; NEUROLEPTIC MALIGNANT SYNDROME; PATIENT CARE; PATIENT MONITORING; PRACTICE GUIDELINE; QT PROLONGATION; SEDATION; SIDE EFFECT; SOMNOLENCE; SYSTEMATIC REVIEW; TORTICOLLIS; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT OUTCOME; TREATMENT RESPONSE; URINARY FREQUENCY; WEIGHT GAIN;

EID: 77950414124     PISSN: 15505952     EISSN: 15555194     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Barzman DH, Findling RL. Pharmacological treatment of pathologic aggression in children. Int Rev Psychiatry. 2008;20(2):151-157.
2. Vitiello B, Hill JL, Elia J, et al. P.R.N. medications in child psychiatric patients: a pilot placebo-controlled study. J Clin Psychiatry. 1991;52(12):499-501.
3. Vitiello B, Ricciuti AJ, Behar D. P.R.N. medications in child state hospital inpatients. J Clin Psychiatry. 1987;48(9):351-354.
4. Srivastava A. Limited evidence for the effectiveness of p.r.n. medications among psychiatric inpatients. J Psychiatr Pract. 2009;15(3):193-201.
5. Chengappa KN, Levine J, Ulrich R, et al. Impact of risperidone on seclusion and restraint at a state psychiatric hospital. Can J Psychiatry. 2000;45(9):827-832.
6. Chengappa KN, Ebeling T, Kang JS, et al. Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder. J Clin Psychiatry. 1999;60(7):477-484.
7. Chengappa KN, Vasile J, Levine J, et al. Clozapine: its impact on aggressive behavior among patients in a state psychiatric hospital. Schizophr Res. 2000;53(1-2),1-6.
8. Delaney KR, Fogg L. Patient characteristics and setting variables related to use of restraint on four inpatient psychiatric units for youths. Psychiatr Serv. 2005;56(2):186-192.
9. Banerji A, Long AA, Camargo CA Jr. Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review. Allergy Asthma Proc. 2007;28(4):418-426.
10. Cummings MR, Miller BD. Pharmacologic management of behavioral instability in medically ill pediatric patients. Curr Opin Pediatr. 2004;16(5):516-522.
11. Meltzer LJ, Mindell JA, Owens JA, Byars KC. Use of sleep medications in hospitalized pediatric patients. Pediatrics. 2007;119(6):1047-1055.
12. Donovan SJ, Stewart JW, Nunes EV et al. Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Am J Psychiatry. 2000;157(5):818-820.
13. Malone RP, Delaney MA, Luebbert JF, et al. A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. Arch Gen Psychiatry. 2000;57(7):649-654.
14. Campbell M, Small AM, Green WH, et al. Behavioral efficacy of haloperidol and lithium carbonate: a comparison in hospitalized aggressive children with conduct disorder. Arch Gen Psychiatry. 1984;41(7):650-656.
15. Rifkin A, Karajgi B, Dicker R, et al. Lithium treatment of conduct disorders in adolescents. Am J Psychiatry. 1997;154(4):554-555.
16. Kafantaris V, Campbell M, Padron-Gayol MV, et al. Carbamazepine in hospitalized aggressive conduct disorder children: an open pilot study. Psychopharmacol Bull. 1992;28(2):193-199.
17. Cueva JE, Overall JE, Small AM, et al. Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry. 1996;35(4):480-490.
18. Findling RL, Steiner H, Weller EB. Use of antipsychotics in children and adolescents. J Clin Psychiatry. 2005;66(7):29-40.
19. Brook S. Intramuscular ziprasidone: moving beyond the conventional in the treatment of acute agitation in schizophrenia. J Clin Psychiatry. 2003;64(Suppl 19):13-18.
20. Khan SS, Mican LM. A naturalistic evaluation of intramuscular ziprasidone versus intramuscular olanzapine for the management of acute agitation and aggression in children and adolescents. J Child Adolesc Psychopharmacol. 2006;16(6):671-677.
21. Barzman DH, DelBello MP, Forrester JJ, et al. A retrospective chart review of intramuscular ziprasidone for agitation in children and adolescents on psychiatric units: Prospective studies are needed. J Child Adolesc Psychopharmacol. 2007;17(4):503-509.
22. Hazaray E, Ehret J, Posey DJ, et al. Intramuscular ziprasidone for acute agitation in adolescents. J Child Adolesc Psychopharmacol. 2004;14(3):464-470.
23. Staller JA. Intramuscular ziprasidone in youth: a retrospective chart review. J Child Adolesc Psychopharmacol. 2004;14(4):590-592.
24. Jangro WC, Preval H, Southard R, et al. Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study. Child Adolesc Psychiatry Ment Health. 2009;3(1):9.
25. Krishnamoorthy J, King BH. Open-label olanzapine treatment in five preadolescent children. J Child Adolesc Psychopharmacol. 1998;8(2):107-113.
26. Parikh MS, Kolevzon A, Hollander E. Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability. J Child Adolesc Psychopharmacol. 2008;18(2):157-178.
27. Armenteros JL, Lewis JE, Davalos M. Risperidone augmentation for treatment-resistant aggression in attention-deficit/hyperactivity disorder: a placebo-controlled pilot study. J Am Acad Child Adolesc Psychiatry. 2007;46(5):558-565.
28. Buitelaar JK, van der Gaag RJ, Cohen-Kettenis P, Melman CT. A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. J Clin Psychiatry. 2001;62(4):239-248.
29. Findling RL, Reed MD, O'Riordan MA, et al. Effectiveness, safety, and pharmacokinetics of quetiapine in aggressive children with conduct disorder. J Am Acad Child Adolesc Psychiatry. 2006;45(7):792-800.
30. Findling R, Blumer J, Kauffman R, et al. Pharmacokinetic effects of aripiprazole in children and adolescents with conduct disorder. Int J Neuropsychopharmacol. 2004;7:S440.
31. Aguilar EJ, Keshavan MS, Martínez-Quiles MD, et al. Predictors of acute dystonia in first-episode psychotic patients. Am J Psychiatry. 1994;151:1819-1821.
32. Singh MK, DelBello MP, Adler CM. Acute dystonia associated with aripiprazole in a child. J Am Acad Child Adolesc Psychiatry. 2007;46(3):306-307.
33. Barzman DH, DelBello MP, Kowatch RA, et al. The effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review. J Child Adolesc Psychopharmacol. 2004;14(4):593-600.
34. Chungh DS, Kim BN, Cho SC. Neuroleptic malignant syndrome due to three atypical antipsychotics in a child. J Psychopharmacol. 2005;19(4):422-425.
35. Massanari M, Novitsky J, Reinstein LJ. Paradoxical reactions in children associated with midazolam use during endoscopy. Clin Pediatr (Phila). 1997;36(12):681-684.
36. O'Brien CP. Benzodiazepine use, abuse, and dependence. J Clin Psychiatry. 2005; 66 Suppl 2:28-33.
37. Birchley G. Opioid and benzodiazepine withdrawal syndromes in the pediatric intensive care unit: a review of recent literature. Nurs Crit Care. 2009;14(1):26-37.
38. Marcus A, Ammermann C, Bahro M, Schmidt MH. Benzodiazepine administration induces exogenic psychosis: a case of child abuse. Child Abuse Negl. 1995;19(7):833-836.
39. Dorfman D, Kastner B. The use of restraint for pediatric psychiatric patients in emergency departments. Pediatr Emerg Care. 2004;20:151-156.
40. Hilt RJ, Woodward TA. Agitation treatment for pediatric emergency patients. J Am Acad Child Adolesc Psychiatry. 2008;47(2):132-138.
41. Connor DF, Steingard RJ, Cunningham JA, et al. Proactive and reactive aggression in referred children and adolescents. Am J Orthopsychiatry. 2004;74(2):129-136.
42. Steiner H, Saxena K, Chang K. Psychopharmacologic strategies for the treatment of aggression in juveniles. CNS Spectr. 2003;8(4):298-308.
43. Greene RW, Ablon JS. Treating Explosive Kids: The Collaborative Problem Solving Approach. New York: Guilford; 2005.
44. Bornman BA, Mitelman SA, Beer DA. Psychotherapeutic relaxation: How it relates to levels of aggression in a school within inpatient child psychiatry: a pilot study. The Arts in Psychotherapy. 2007;34(3):216-222.
45. Malone RP, Luebbert JF, Delaney MA. Nonpharmacological response in hospitalized children with conduct disorder. J Am Acad Child Adolesc Psychiatry. 1997;36(2):242-247.
46. dosReis S, Barnett S, Love RC, Riddle MA. The Maryland Youth Practice Improvement Committee. A guide for managing acute aggressive behavior of youths in residential and inpatient treatment facilities. Psychiatric Serv. 2003;54(10):1357-1363.
47. Jangro WC, Preval H, Southard R, Klotz SG, et al. Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study. Child Adolesc Psychiatry Ment Health. 2009;3(1):9.