Dimeric Lea (Lea-on-Lea) status of ß-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects

International Journal of Oncology

Volumn 36, Issue 5, 2010, Pages 1291-1297

  Park, Seung Yeol ^a,b,c   Yoon, Seon Joo ^b,c,f   Hakomori, Sen Itiroh ^b,c   Kim, Jin Man ^d   Kim, Ji Yeon ^d   Bernert, Bradford ^e   Ullman, Thomas ^e   Itzkowitz, Steven H ^e   Kim, Jung Hoe ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Chungnam National University College of Medicine   (South Korea)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f Yonsei University   (South Korea)

Author keywords

Colon cancer; Dimeric Lea; Haptoglobin; Lectin blotting; O linked glycan

Indexed keywords

ALPHA LEVO FUCOSIDASE; BETA HAPTOGLOBIN; GLYCAN; GLYCOPEPTIDASE; GLYCOSIDASE; HAPTOGLOBIN; LE ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NCC ST 421; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CHRONIC INFLAMMATION; COLON CANCER; CONTROLLED STUDY; CROHN DISEASE; GLYCOSYLATION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ALPHA-L-FUCOSIDASE; ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; COLONIC NEOPLASMS; EPITOPES; GANGLIOSIDES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSPHINGOLIPIDS; HAPTOGLOBINS; HUMANS; INFLAMMATION; MICE; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; POLYSACCHARIDES;

EID: 77950408693     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000614     Document Type: Article

References (36)

1. Hakomori S: Glycosylation defining cancer malignancy: New wine in an old bottle. Proc Natl Acad Sci USA 99: 10231-10233, 2002.
2. Seelentag WKF, Li W-P, Schmitz S-FH, Metzger U, Aeberhard P, Heitz PU and Roth J: Prognostic value of b1,6-branched oligosaccharides in human colorectal carcinoma. Cancer Res 58: 5559-5564, 1998.
3. Dennis JW and Laferté S: Oncodevelopmental expression of -GlcNAcb1-6Mana1-6Manb1-6 branching of Asn-linked-oligosaccharides in human breast carcinomas. Cancer Res 49: 945-950, 1989.
4. Turner GA: N-glycosylation of serum proteins in disease and its investigation using lectins. Clin Chim Acta 208: 149-171, 1992.
5. Turner GA, Skillen AW, Buamah P, Guthrie D, Welsh J, Harrison J and Kowalski A: Relation between raised concentrations of fucose, sialic acid, and acute phase proteins in serum from patients with cancer: choosing suitable serum glycoprotein markers. J Clin Pathol 38: 588-592, 1985.
6. Slovin SF, Ragupathi G, Adluri S, Ungers G, Terry K, Kim S, Spassova M, Bornmann WG, Fazzari M, Dantis L, Olkiewicz K, Lloyd KO, Livingston PO, Danishefsky SJ and Scher HI: Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man. Proc Natl Acad Sci USA 96: 5710-5715, 1999.
7. Holmberg LA, Oparin DV, Gooley T, Lilleby K, Bensinger W, Reddish MA, MacLean GD, Longenecker BM and Sandmaier BM: Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE STn-KLH cancer vaccine. Bone Marrow Transplant 25: 1233-1241, 2000.
8. Livingston PO: Carbohydrate vaccines that induce antibodies against cancer. 1. Rationale. Cancer Immunol Immunother 45: 1-9, 1997.
9. Ragupathi G, Livingston PO, Hood C, Gathuru J, Krown SE, Chapman PB, Wolchok JD, Williams LJ, Oldfield RC and Hwu WJ: Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactonekeyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21. Clin Cancer Res 9: 5214-5220, 2003.
10. Gilewski TA, Ragupathi G, Dickler M, Powell S, Bhuta S, Panageas K, Koganty RR, Chin-Eng J, Hudis C, Norton L, Houghton AN and Livingston PO: Immunization of high-risk breast cancer patients with clustered sTn-KLH conjugate plus the immunologic adjuvant QS-21. Clin Cancer Res 13: 2977-2985, 2007.
11. Hakomori S: Tumor-associated carbohydrate antigens defining tumor malignancy: Basis for development of anti-cancer vaccines. Adv Exp Med Biol 491: 369-402, 2001.
12. Galonic DP and Gin DY: Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines. Nature 446: 1000-1007, 2007.
13. a) epitope. Cancer Res 51: 2199-2204, 1991.
14. 6) as human tumor-associated antigen. J Biol Chem 266: 8439-8446, 1991.
15. a glycosphingolipid, a novel extended type 1 chain antigen. Cancer Res 52: 3739-3745, 1992.
16. 6). Eur J Biochem 203: 577-586, 1992.
17. Turner GA: Haptoglobin. A potential reporter molecule for glycosylation changes in disease. Adv Exp Med Biol 376: 231-238, 1995.
18. Fujimura T, Shinohara Y, Tissot B, Pang PC, Kurogochi M, Saito S, Arai Y, Sadilek M, Murayama K, Dell A, Nishimura S and Hakomori SI: Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects. Int J Cancer 122: 39-49, 2008.
19. Okuyama N, Ide Y, Nakano M, Nakagawa T, Yamanaka K, Moriwaki K, Murata K, Ohigashi H, Yokoyama S, Eguchi H, Ishikawa O, Ito T, Kato M, Kasahara A, Kawano S, Gu J, Taniguchi N and Miyoshi E: Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. Int J Cancer 118: 2803-2808, 2006.
20. Nakano M, Nakagawa T, Ito T, Kitada T, Hijioka T, Kasahara A, Tajiri M, Wada Y, Taniguchi N and Miyoshi E: Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: A novel approach for the development of tumor markers. Int J Cancer 122: 2301-2309, 2008.
21. Semple TU, Quinn LA, Woods LK and Moore GE: Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model. Cancer Res 38: 1345-1355, 1978.
22. Watanabe M, Hirohashi S, Shimosato Y, Ino Y, Yamada T, Teshima S, Sekine T and Abe O: Carbohydrate antigen defined by a monoclonal antibody raised against a gastric cancer xenograft. Jpn J Cancer Res 76: 43-52, 1985.
23. Young WW, MacDonald EMS, Nowinski RC and Hakomori S: Production of monoclonal antibodies specific for distinct portions of the glycolipid asialo GM2 (gangliotriosylceramide). J Exp Med 150: 1008-1019, 1979.
24. Kannagi R, Nudelman ED, Levery SB and Hakomori S: A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen, SSEA-1. J Biol Chem 257: 14865-14874, 1982.
25. 3 a(NeuGca2-8NeuGc)-Gg4Cer, is a major disialoganglioside in WHT/Ht mouse thymoma and thymocytes. J Biochem 110: 832-841, 1991.
26. Skipski VP: Thin layer chromatography of neutral glycosphingolipids. Methods Enzymol 35: 396-425, 1975.
27. Yoon S, Nakayama K, Hikita T, Handa K and Hakomori S: Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. Proc Natl Acad Sci USA 103: 18987-18991, 2006.
28. Park S-Y, Yoon S-J, Jeong Y-T, Kim J-M, Kim J-Y, Bernert B, Ullman T, Itzkowitz SH, Kim J-H and Hakomori S: N-glycosylation status of ß-haptoglobin in sera of patients with colon cancer, colon inflammatory diseases and normal subjects. Int J Cancer 126: 142-155, 2010.
29. Kuan S-F, Byrd JC, Basbaum C and Kim YS: Inhibition of mucin glycosylation by aryl-N-acetyl-alpha-galactosaminides in human colon cancer cells. J Biol Chem 264: 19271-19277, 1989.
30. Hakomori S: Traveling for the glycosphingolipid path. Glycoconj J 17: 627-647, 2000.
31. Muramatsu T, Muramatsu H, Gachelin G and Jacob F. High molecular weight carbohydrates on embryonal carcinoma cells. In: Teratocarcinoma and Embryonic Cell Interactions. T. Muramatsu, G. Gachelin, A.A. Moscona and Y. Ikawa (eds). Japan Scientific Societies Press, Tokyo, pp143-156, 1982.
32. x expression. Glycoconj J 11: 238-248, 1994.
33. Handa K, Takatani-Nakase T, Larue L, Stemmler MP, Kemler R and Hakomori S: Lex glycan mediates homotypic adhesion of embryonal cells independently from E cadherin: A preliminary note. Biochem Biophys Res Commun 358: 247-252, 2007.
34. Prokop O and Uhlenbruck G. The Lewis-System. In: Human Blood and Serum Groups (English translation). O. Prokop and G. Uhlenbruck (eds). MacLaren and Sons, London, pp276-286, 1969.
35. Langlois MR and Delanghe JR: Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 42: 1589-1600, 1996.
36. Thompson S and Turner GA: Elevated levels of abnormally-fucosylated haptoglobins in cancer sera. Br J Cancer 56: 605-610, 1987.