Fucosylated haptoglobin is a novel marker for pancreatic cancer: A detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation

International Journal of Cancer

Volumn 118, Issue 11, 2006, Pages 2803-2808

  Okuyama, Noriko ^a,b   Ide, Yoshihito ^a   Nakano, Miyako ^a   Nakagawa, Tsutomu ^a   Yamanaka, Kanako ^a,b   Moriwaki, Kenta ^a,b   Murata, Kohei ^c   Ohigashi, Hiroaki ^c   Yokoyama, Shigekazu ^c   Eguchi, Hidetoshi ^c   Ishikawa, Osamu ^c   Ito, Toshifumi ^d   Kato, Michio ^e   Kasahara, Akinori ^a   Kawano, Sunao ^b   Gu, Jianguo ^a   Taniguchi, Naoyuki ^a   Miyoshi, Eiji ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^d KANSAI ROSAI HOSPITAL   (Japan)

^e OSAKA NATIONAL HOSPITAL   (Japan)

Author keywords

Fucosylation; Fucosyltransferase; Haptoglobin; Lectin; Mass spectrometry; Oligosaccharide; Pancreatic cancer; Tumor marker

Indexed keywords

HAPTOGLOBIN; OLIGOSACCHARIDE; TUMOR MARKER;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOHYDRATE ANALYSIS; COLON CANCER; CONTROLLED STUDY; FEMALE; FUCOSYLATION; HEPATOMA CELL; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN SECRETION; STOMACH CANCER;

BLOTTING, WESTERN; FEMALE; GLOBINS; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 33646343959     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.21728     Document Type: Article

References (24)

1. Greenlee RT, Murray T, Boldon S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000;50:7-33.
2. Friess H, Kleeff J, Kulli C, Wagner M, Sawhney H, Buchler MW. The impact of different types of surgery in pancreatic cancer. Eur J Surg Oncol 1999;25:124-31.
3. Rosty C, Goggins M. Early detection of pancreatic carcinoma. Hematol Oncol Clin North Am 2002;16:37-52.
4. Hakomori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigen. Adv Cancer Res 1989;52:257-331.
5. Morinaga T, Sakai M, Wegmann TG, Tamaoki T. Primary structures of human alpha-fetoprotein and its mRNA. Proc Natl Acad Sci USA 1983;80:4604-8.
6. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Endo Y, Nagataki S. Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 1993;328:1802-6.
7. Taketa K, Endo Y, Sekiya C, Tanikawa K, Koji T, Taga H, Satomura S, Matsuura S, Kawai T, Hirai H. A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res 1993;53:5419-23.
8. Yamashita F, Tanaka M, Satomura S, Tanikawa K. Prognostic significance of Lens culinaris agglutinin A-reactive alpha-fetoprotein in small hepatocellular carcinomas. Gastroenterology 1996;111:996-1001.
9. Tatsumura T, Sato H, Mori A, Komori Y, Yamamoto K, Fukatani G, Kuno S. Clinical significance of fucose level in glycoprotein fraction of serum in patients with malignant tumors. Cancer Res 1977;37:4101-3.
10. Saitoh O, Wang WC, Lotan R, Fukuda M. Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials. J Biol Chem 1992;267:5700-11.
11. Goupille C, Hallouin F, Meflah K, Le Pendu J. Increase of rat colon carcinoma cells tumorigenicity by alpha (1-2) fucosyltransferase gene transfection. Glycobiology 1997;7:221-9.
12. Martin-Satue M, Marrugat R, Cancelas JA, Blanco J. Enhanced expression of alpha (1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer Res 1998;58:1544-50.
13. Yamashita K, Kochibe N, Ohkura T, Ueda I, Kobata A. Fractionation of L-fucose-containing oligosaccharides on immobilized Aleuria aurantia lectin. J Biol Chem 1985;260:4688-93.
14. Noda K, Miyoshi E, Gao C-X, Nakahara S, Kitada T, Honke K, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Tonetti M, Taniguchi N, et al. Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res 2003;63:6282-9.
15. Ishida H, Moritani T, Hata Y, Kawato A, Suginami K, Abe Y, Imayasu S. Molecular cloning and overexpression of fleA gene encoding a fucose-specific lectin of Aspergillus oryzae. Biosci Biotechnol Biochem 2002;66:1002-8.
16. Miyoshi E, Uozumi N, Noda K, Hayashi N, Hori M, Taniguchi N. Expression of alpha 1-6 fucosyltransferase in rat tissues and human cancer cell lines. Int J Cancer 1997:72:1117-21.
17. Turner GA. Haptoglobin. A potential reporter molecule for glycosylation changes in disease. Adv Exp Med Biol 1995;376:231-8.
18. Thompson S, Turner GA. Elevated levels of abnormally-fucosylated haptoglobins in cancer sera. Br J Cancer 1987;56:605-10.
19. Thompson S, Dargan E, Griffiths ID, Kelly CA, Turner GA. The glycosylation of haptoglobin in rheumatoid arthritis. Clin Chim Acta 1993;220:107-14.
20. Thompson S, Dargan E, Turner GA. Increased fucosylation and other carbohydrate changes in haptoglobin in ovarian cancer. Cancer Lett 1992;66:43-8.
21. Goodarzi MT, Turner GA. Reproducible and sensitive determination of changed oligosaccharides from haptoglobin by PNGase F digestion and HPAEC/PAD analysis: glycan composition varies with disease. Glycoconj J 1998;15:469-75.
22. Marta Piva J. Ignacio Moreno, Kathy L. Sharpe-Timms. Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin. Glycoconj J 2002;19:33-41.
23. Mann AC, Record CO, Self CH, Turner GA. Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease. Clin Chim Acta 1994;227:69-78.
24. Ekuni A, Miyoshi E, Ko JH, Noda K, Kitada T, Ihara S, Endo T, Hino A, Honke K, Taniguchi N. A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitorsamine (DEN): identification of haptoglobin as a target molecule of GnT-III. Free Radic Res 2002;36:827-33.