Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Prasad, Pushplata ^a   Tiwari, Arun K ^a   Kumar, K M Prasanna ^b   Ammini, A C ^c   Gupta, Arvind ^d   Gupta, Rajeev ^e   Thelma, B K ^a  

^a UNIVERSITY OF DELHI   (India)

^b M S RAMAIAH MEDICAL COLLEGE   (India)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^d Jaipur Engineering College and Research Centre   (India)

^e Monilek Hospital and Research Centre   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALDOKETOREDUCTASE FAMILY 1 MEMBER B1; CHEMOKINE; CREATININE; CYTOKINE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE 2; MICRORNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OXIDOREDUCTASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; AKR1B10 PROTEIN, HUMAN; ALDEHYDE REDUCTASE; ART1 PROTEIN, HUMAN; GFPT2 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

3' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; ASIAN; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE DURATION; ETHNICITY; FEMALE; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; ASIA; ETHNOLOGY; GENE FREQUENCY; GENETIC MARKER; GENETICS; HOMOZYGOTE; INDIA; MIDDLE AGED;

ADP RIBOSE TRANSFERASES; ADULT; ALDEHYDE REDUCTASE; ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HOMOZYGOTE; HUMANS; INDIA; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IMMUNOLOGIC; RENAL INSUFFICIENCY, CHRONIC;

EID: 77950396880     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-52     Document Type: Article

References (47)

1. Wang Y, Ng MC, Lee SC, So WY, Tong PC, Cockram CS, Critchley JA, Chan JC. Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care 2003, 26:2410-5. 10.2337/diacare.26.8.2410, 12882871.
2. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-20. 10.1038/414813a, 11742414.
3. Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, Sharma AK, Rao AR, Nagendra R, Chandra TS, Tiwari SC, Rastogi P, Gupta BL, Thelma BK. Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. BMC Med Genet 2006, 7:42. 10.1186/1471-2350-7-42, 1479320, 16672053.
4. Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, Thelma BK. Association of TGFbeta1, TNF alpha, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians. BMC Med Genet 2007, 8:20. 10.1186/1471-2350-8-20, 1853079, 17428349.
5. Prasad P, Kumar KM, Ammini AC, Gupta A, Gupta R, Thelma BK. Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Genet 2008, 9:26. 10.1186/1471-2156-9-26, 2287188, 18366720.
6. Tiwari AK, Prasad P, BK T, Prasanna Kumar KM, Ammini AC, Gupta A, Gupta R. Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes. J Diabetes Complications 2009, 23:102-111. 10.1016/j.jdiacomp.2007.10.003, 18413200.
7. Sorbinil Retinopathy Trial Research Group A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch Ophthalmol 1990, 108:1234-1244. Sorbinil Retinopathy Trial Research Group.
8. Soulis-Liparota T, Cooper M, Papazoglou D, Clarke B, Jerums G. Retardation byaminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat. Diabetes 1991, 40:1328-1334. 10.2337/diabetes.40.10.1328, 1834497.
9. Nakamura S, Makita Z, Ishikawa S, Yasumura K, Fujii W, Yanagisawa K, Kawata T, Koike T. Progression of nephropathy in spontaneous diabetic rats is prevented by OPB- a novel inhibitor of advanced glycation. Diabetes 9195, 46:895-899.
10. Shestakov AE, Kamyshova ES, Petrosian EK, Kutyrina IM, Savost'ianov KV, Nosikov VV. Polymorphic markers Val762Ala and Leu54Phe of the ADPRT1 gene associated with chronic glomerulonephritis in Russian patients from the city of Moscow. Genetika 2007, 43:261-4.
11. Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M. Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes. Diabet Med 2004, 21:1325-33. 10.1111/j.1464-5491.2004.01345.x, 15569136.
12. Donaghue KC, Margan SH, Chan AK, Holloway B, Silink M, Rangel T, Bennetts B. The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents. Diabet Med 2005, 22:1315-20. 10.1111/j.1464-5491.2005.01631.x, 16176189.
13. Makiishi T, Araki S, Koya D, Maeda S, Kashiwagi A, Haneda M. C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus. Am J Kidney Dis 2003, 42:943-51. 10.1016/j.ajkd.2003.06.003, 14582038.
14. Wolford JK, Yeatts KA, Red Eagle AR, Nelson RG, Knowler WC, Hanson RL. Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians. Diabet Med 2006, 23:367-76. 10.1111/j.1464-5491.2006.01834.x, 16620264.
15. Richeti F, Noronha RM, Waetge RT, de Vasconcellos JP, de Souza OF, Kneipp B, Assis N, Rocha MN, Calliari LE, Longui CA, Monte O, de Melo MB. Evaluation of AC(n) and C(-106)T polymorphisms of the aldose reductase gene in Brazilian.
16. Vlassara H. The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab Res Rev 2001, 17:436-43. 10.1002/dmrr.233, 11757079.
17. Damiani G, Campo I, Zorzetto M, Bozzi V, Disabella E, Caroli A, Ferrarotti I, D'Annunzio G, Pasi A, Martinetti M, Cuccia M. Pro-inflammatory variants of DRB1 and RAGE genes are associated with susceptibility to pediatric type 1 diabetes: a new hypothesis on the adaptive role of autoimmunity. Riv Biol 2007, 100:285-304.
18. Hudson BI, Stickland MH, Grant PJ. Identification of polymorphisms in the receptor for advanced glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups. Diabetes 1998, 47:1155-7. 10.2337/diabetes.47.7.1155, 9648842.
19. Berberoǧlu M, Evliyaoǧlu O, Adiyaman P, Ocal G, Ulukol B, Simşek F, Siklar Z, Törel A, Ozel D, Akar N. Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children. J Pediatr Endocrinol Metab 2006, 19:741-8.
20. Jeng JR. Plasma adiponectin, T94G gene polymorphism and PAI-1 in patients with and without hypertension. Cardiology 2007, 107:30-7. 10.1159/000093610, 16741355.
21. Santos KG, Tschiedel B, Schneider J, Souto K, Roisenberg I. Diabetic retinopathy in Euro-Brazilian type 2 diabetic patients: relationship with polymorphisms in the aldose reductase, the plasminogen activator inhibitor-1 and the methylenetetrahydrofolate reductase genes. Diabetes Res Clin Pract 2003, 61:133-6. 10.1016/S0168-8227(03)00112-8, 12951282.
22. Lopes C, Dina C, Durand E, Froguel P. PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population. Diabetologia 2003, 46:1284-90. 10.1007/s00125-003-1170-0, 12856128.
23. Globocnik-Petrovic M, Hawlina M, Peterlin B, Petrovic D. Insertion/deletion plasminogen activator inhibitor 1 and insertion/deletion angiotensin-converting enzyme gene polymorphisms in diabetic retinopathy in type 2 diabetes. Ophthalmologica 2003, 217:219-24. 10.1159/000068975, 12660488.
24. Tarnow L, Stehouwer CD, Emeis JJ, Poirier O, Cambien F, Hansen BV, Parving HH. Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy. Nephrol Dial Transplant 2000, 15:625-30. 10.1093/ndt/15.5.625, 10809802.
25. Wong TY, Poon P, Szeto CC, Chan JC, Li PK. Association of plasminogen activator inhibitor-1 4G/4G genotype and type 2 diabetic nephropathy in Chinese patients. Kidney Int 2000, 57:632-8. 10.1046/j.1523-1755.2000.00884.x, 10652041.
26. Kimura H, Gejyo F, Suzuki Y, Suzuki S, Miyazaki R, Arakawa M. Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy. Kidney Int 1998, 54:1659-69. 10.1046/j.1523-1755.1998.00139.x, 9844142.
27. Mansfield MW, Stickland MH, Carter AM, Grant PJ. Polymorphisms of the plasminogen activator inhibitor-1 gene in type 1 and type 2 diabetes, and in patients with diabetic retinopathy. Thromb Haemost 1994, 71:731-6.
28. Zhang H, Jia Y, Cooper JJ, Hale T, Zhang Z, Elbein SC. Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. J Clin Endocrinol Metab 2004, 89:748-55. 10.1210/jc.2003-031286, 14764791.
29. Weigert C, Friess U, Brodbeck K, Haring HU, Schleicher ED. Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells. Diabetologia 2003, 46:852-5. 10.1007/s00125-003-1122-8, 12802498.
30. Kim DK, Kim JW, Kim S, Gwon HC, Ryu JC, Huh JE, Choo JA, Choi Y, Rhee CH, Lee WR. Polymorphism of angiotensin converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 1997, 17:3242-7.
31. Brown NJ, Agirbasli MA, Williams GH, Litchfield WR, Vaughan DE. Effect of activation and inhibition of the renin-angiotensin system on plasma PAI-1. Hypertension 1998, 32:965-71.
32. Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A. Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Kidney Int 1997, 51:164-72. 10.1038/ki.1997.20, 8995730.
33. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999, 130:461-70.
34. Gordon D, Finch SJ, Nothnagel M, Ott J. Power and sample size calculations for case-control genetic association tests when errors present: application to single nucleotide polymorphisms. Human Heredity 2002, 54:22-33. 10.1159/000066696, 12446984.
35. Gordon D, Levenstien MA, Finch SJ, Ott J. Errors and linkage disequilibrium interact multiplicatively when computing sample sizes for genetic case-control association studies. Pacific Symposium on Biocomputing 2003, 490-501.
36. Gohda T, Tanimoto M, Watanabe-Yamada K, Matsumoto M, Kaneko S, Hagiwara S, Shiina K, Shike T, Funabiki K, Tomino Y. Genetic susceptibility to type 2 diabetic nephropathy in human and animal models. Nephrology (Carlton) 2005, 10(Suppl):S22-5. 10.1111/j.1440-1797.2005.00452.x, 16174283.
37. Chowdhury TA, Dyer PH, Kumar S, Barnett AH, Bain SC. Genetic determinants of diabetic nephropathy. Clin Sci (Lond) 1999, 96:221-30. 10.1042/CS19980331, 10029557.
38. Wong C, Kanetsky P, Raj D. Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease. Pediatr Nephro 2008, 23:1037-51.
39. Brownlee M. Advanced protein glycosylation in diabetes and aging. Ann Rev Med 1995, 46:223-34. 10.1146/annurev.med.46.1.223, 7598459.
40. Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. Cellular receptors for advanced glycation end products: implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 1994, 14:1521-8.
41. Sugaya K, Fukagawa T, Matsumoto KI, Mita K, Takahashi EI, Ando A, Inoko H, Ikemura T. Three genes in the human MHC class II region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. Genomics 1994, 23:408-19. 10.1006/geno.1994.1517, 7835890.
42. Soulis T, Thallas V, Youssef S, Gilbert RE, McWilliam BG, Murray-McIntosh RP, Cooper ME. Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury. Diabetologia 1997, 40:619-28. 10.1007/s001250050725, 9222639.
43. Hudson BI, Stickland MH, Futers TS, Grant PJ. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. Diabetes 2001, 50:1505-11. 10.2337/diabetes.50.6.1505, 11375354.
44. Crook ED, Simmons ST, Daniels M, Singh LP. Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor β in rat mesangial cells. J Investig Med 2000, 48:427-34.
45. Schleicher ED, Weigert C. Role of the hexosamine biosynthetic pathway in diabetic nephropathy. Kidney Int 2000, 77(Suppl):S13-8.
46. Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M. Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes. Diabet Med 2004, 21:1325-33. 10.1111/j.1464-5491.2004.01345.x, 15569136.
47. Donaghue KC, Margan SH, Chan AK, Holloway B, Silink M, Rangel T, Bennetts B. The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents. Diabet Med 2005, 22:1315-20. 10.1111/j.1464-5491.2005.01631.x, 16176189.