Critical role of c-Met and Ki67 in progress of biliary carcinoma

American Surgeon

Volumn 76, Issue 4, 2010, Pages 372-379

  Sanada, Yuichi ^a   Osada, Shinji ^a   Tokuyama, Yasuharu ^a   Tanaka, Yoshihiro ^a   Takahashi, Takao ^a   Yamaguchi, Kazuya ^a   Yoshida, Kazuhiro ^a  

^a Graduate School of Medicine   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; SCATTER FACTOR RECEPTOR;

ARTICLE; BILE DUCT CARCINOMA; CANCER GROWTH; CARCINOGENESIS; CELL MEMBRANE; CELL NUCLEUS; GALLBLADDER CARCINOMA; HUMAN; HUMAN TISSUE; INVASIVE CARCINOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNET RING CARCINOMA; SQUAMOUS CELL CARCINOMA; UNDIFFERENTIATED CARCINOMA;

BILE DUCT NEOPLASMS; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROTO-ONCOGENE PROTEINS C-MET; TUMOR MARKERS, BIOLOGICAL;

EID: 77950388953     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Jarnagin WR, Klimstra DS, Hezel M, et al. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. J Clin Oncol 2006;24:1152-1160
2. Kitajima Y, Ide T, Ohtsuka T, et al. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. Cancer Sci 2008;99:1341-1347
3. Ide T, Kitajima Y, Miyoshi A, et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol 2007;14:2600-2607
4. Terada T, Nakamura Y, Sirica AE. Immunohistochemical demonstration of Met overexpression in human intrahepatic cholangiocarcinoma and hepatolithiasis. Hum Pathol 1998;29:175-180
5. Furukawa T, Duguid WP, Kobari M, et al. Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. Am J Pathol 1995;147:889-895
6. Sanada Y, Yoshida K, Ohara M, et al. Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2. Pancreas 2006;32:164-170
7. Sanada Y, Yoshida K. Immunohistochemical analyses in intraductal gradually transitional components is useful for evaluation of stepwise progression of pancreatic intraepithelial neoplasia. Pancreas 2007;35:101-103
8. Sanada Y, Yoshida K, Hihara J, et al. Expression of Orotate phosphoribosyltransferase in colorectal carcinoma: an immunohistochemical analysis in several components of neoplastic lesions. Oncol Rep 2008;20:1005-1011
9. Sanada Y, Yoshida K, Ohara M, et al. Expression of Orotate phosphoribosyltransferase in hepatobiliary and pancreatic carcinoma. Pathol Oncol Res 2007;13:105-113
10. Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 2001;33:1353-1357
11. Itatsu K, Zen Y, Ohira S, et al. Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int 2007;27:1174-1184
12. Aishima S, Taguchi K, Sugimachi K, et al. c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma. Histopathology 2002;40:269-278
13. Suto T, Sugai T, Nakamura S, et al. Assessment of the expression of p53, MIB-1 (Ki67 antigen), and Argyrophilic nuclear organizer regions in carcinoma of the extrahepatic bile duct. Cancer 1998;82:86-95.
14. Nakazawa K, Dobashi Y, Suzuki S, et al. Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-Met in biliary tract cancers. J Pathol 2005;206:356-365
15. Radaeva S, Ferreria-Gonzales A, Sirica E. Overexpression of c-NE U and c-Met during rat liver cholangiocarcinogenesis: a link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma. Hepatology 1999;29:1462.
16. Saitoh K, Takahashi H, Sawada N, et al. Detection of the c-Met proto-oncogene product in normal skin and tumours of melanocytic origin. J Pathol 1994;174:191-199
17. Tward AD, Jones KD, Yant S, et al. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci USA 2007;104:14771-14776
18. Galleo MI, Bierie B, Hennighausen L. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. Oncogene 2003;22:8498-8508