Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1

American Journal of Hematology

Volumn 85, Issue 4, 2010, Pages 227-233

  Davenport, Gregory C ^a   Ouma, Collins ^b,c   Hittner, James B ^d   Were, Tom ^b   Ouma, Yamo ^b   Ong'echa, John M ^b   Perkins, Douglas J ^b,e  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c MASENO UNIVERSITY   (Kenya)

^d School of Business   (United States)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; COTRIMOXAZOLE; HEMOGLOBIN; QUININE;

AGE; ANEMIA; ARTICLE; CHILD; DISEASE EXACERBATION; DISEASE SEVERITY; ENDEMIC DISEASE; ERYTHROPOIESIS; FEMALE; GLYCOGEN STORAGE DISEASE TYPE 1; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFANT; KENYA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MONOCYTOSIS; MORTALITY; PARASITE TRANSMISSION; PARASITEMIA; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; SICKLE CELL TRAIT;

ACUTE DISEASE; AGING; ANEMIA; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HEMATOLOGIC TESTS; HEMEPROTEINS; HEMOGLOBINS; HIV INFECTIONS; HIV-1; HUMANS; INFANT; KENYA; LEUKOCYTE COUNT; MALARIA, FALCIPARUM; MALE; MONOCYTES; NEUTROPHILS; PLASMODIUM FALCIPARUM; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC;

EID: 77950374920     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21653     Document Type: Article

References (65)

1. World Health Organization. World Malaria Report 2008. Geneva: World Health Organization; WHO/HTM/GMP/2008.1.
2. HIV/AIDS JUNPo. 2008 Report on the Global AIDS Epidemic. Geneva: UNAIDS; UNAIDS/08.25E/JC1510E (English original, August 2008).
3. Muller O, Musoke P, Sen G, Moser R. Pediatric HIV-1 disease in a Kampala Hospital. J Trop Pediatr 1990;36:283-286.
4. Kalyesubula I, Musoke-Mudido P, Marum L, et al. Effects of malaria infection in human immunodeficiency virus type 1-infected Ugandan children. Pediatr Infect Dis J 1997;16:876-881. (Pubitemid 27402709)
5. Greenberg AE, Nsa W, Ryder RW, et al. Plasmodium falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in Kinshasa, Zaire. A prospective, longitudinal cohort study of 587 children. N Engl J Med 1991;325:105-109.
6. Colebunders R, Bahwe Y, Nekwei W, et al. Incidence of malaria and efficacy of oral quinine in patients recently infected with human immunodeficiency virus in Kinshasa, Zaire. J Infect 1990;21:167-173.
7. Nguyen-Dinh P, Greenberg AE, Mann JM, et al. Absence of association between Plasmodium falciparum malaria and human immunodeficiency virus infection in children in Kinshasa, Zaire. Bull World Health Organ 1987;65:607-613.
8. Whitworth JA, Hewitt KA. Effect of malaria on HIV-1 progression and transmission. Lancet 2005;365:196-197.
9. Whitworth J, Morgan D, Quigley M, et al. Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: A cohort study. Lancet 2000;356:1051-1056.
10. Van Eijk AM, Ayisi JG, Ter Kuile FO, et al. Malaria and human immunodeficiency virus infection as risk factors for anemia in infants in Kisumu, western Kenya. Am J Trop Med Hyg 2002;67:44-53.
11. Kublin JG, Patnaik P, Jere CS, et al. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: A prospective cohort study. Lancet 2005;365:233-240. (Pubitemid 40138017)
12. Grimwade K, Swingler G. Cotrimoxazole prophylaxis for opportunistic infections in children with HIV infection. Cochrane Database Syst Rev 2003;CD003508, 25(1).
13. Grimwade K, French N, Mbatha DD, et al. HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa. AIDS 2004;18:547-554. (Pubitemid 38365884)
14. Cohen C, Karstaedt A, Frean J, et al. Increased prevalence of severe malaria in HIV-infected adults in South Africa. Clin Infect Dis 2005;41:1631-1637. (Pubitemid 41691603)
15. Hoffman IF, Jere CS, Taylor TE, et al. The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS 1999;13:487-494.
16. Mwapasa V, Rogerson SJ, Molyneux ME, et al. The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women. AIDS 2004;18:1051-1059. (Pubitemid 38591197)
17. Abdalla SH. Hematopoiesis in human malaria. Blood Cells 1990;16:401-416; discussion 417-419
18. Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: A systematic review of the literature. Am J Med 2004;116 (Suppl 7A):27S-43S.
19. Sen R, Tewari AD, Sehgal PK, et al. Clinico-haematological profile in acute and chronic Plasmodium falciparum malaria in children. J Commun Dis 1994;26:31-38.
20. Shearer WT, Rosenblatt HM, Gelman RS, et al. Lymphocyte subsets in healthy children from birth through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol 2003;112:973-980.
21. Brentlinger PE, Behrens CB, Kublin JG. Challenges in the prevention, diagnosis, and treatment of malaria in human immunodeficiency virus infected adults in sub-Saharan Africa. Arch Intern Med 2007;167:1827-1836.
22. Otieno RO, Ouma C, Ong'echa JM, et al. Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria. AIDS 2006;20:275-280.
23. Briand V, Badaut C, Cot M. Placental malaria, maternal HIV infection and infant morbidity. Ann Trop Paediatr 2009;29:71-83.
24. Ter Kuile FO, Parise ME, Verhoeff FH, et al. The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in subsaharan Africa. Am J Trop Med Hyg 2004;71:41-54.
25. Awandare GA, Ouma Y, Ouma C, et al. Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia. Infect Immun 2007;75:201-210. (Pubitemid 46047894)
26. Keller CC, Yamo O, Ouma C, et al. Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: In vivo and in vitro findings in severe malarial anemia. Infect Immun 2006;74:5249-5260.
27. Amodu OK, Adeyemo AA, Olumese PE, Gbadegesin RA. Intraleucocytic malaria pigment and clinical severity of malaria in children. Trans R Soc Trop Med Hyg 1998;92:54-56. (Pubitemid 28073730)
28. Lyke KE, Diallo DA, Dicko A, et al. Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria. Am J Trop Med Hyg 2003;69:253-259.
29. Nguyen PH, Day N, Pram TD, et al. Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg 1995;89:200-204.
30. Egan TJ. Physico-chemical aspects of hemozoin (malaria pigment) structure and formation. J Inorg Biochem 2002;91:19-26.
31. Arese P, Schwarzer E. Malarial pigment (haemozoin): A very active 'inert' substance. Ann Trop Med Parasitol 1997;91:501-516.
32. Schwarzer E, Alessio M, Ulliers D, Arese P. Phagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes. Infect Immun 1998;66:1601-1606. (Pubitemid 128471524)
33. Mcelroy PD, Lal AA, Hawley WA, et al. Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project. Am J Trop Med Hyg 1999;61:932-940.
34. Snow RW, Omumbo JA, Lowe B, et al. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 1997;349:1650-1654. (Pubitemid 27234806)
35. Beier JC, Oster CN, Onyango FK, et al. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am J Trop Med Hyg 1994;50:529-536.
36. Ong'echa JM, Keller CC, Were T, et al. Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area. Am J Trop Med Hyg 2006;74:376-385.
37. Cappadoro M, Giribaldi G, O'brien E, et al. Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. Blood 1998;92:2527-2534.
38. Ruwende C, Hill A. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 1998;76:581-588.
39. Severe falciparum malaria. World Health Organization. Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 2000;94 (Suppl 1): S1-90.
40. Were T, Hittner JB, Ouma C, et al. Suppression of RANTES in children with Plasmodium falciparum malaria. Haematologica 2006;91:1396-1399. (Pubitemid 44569816)
41. Brent AJ, Oundo JO, Mwangi I, et al. Salmonella bacteremia in Kenyan children. Pediatr Infect Dis J 2006;25:230-236.
42. Calis JC, Phiri KS, Faragher EB, et al. Severe anemia in Malawian children. N Engl J Med 2008;358:888-899.
43. Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 2008;371:64-74.
44. Min-Oo G, Gros P. Erythrocyte variants and the nature of their malaria protective effect. Cell Microbiol 2005;7:753-763. (Pubitemid 40740372)
45. Bloland PB, Ruebush TK, Mccormick JB, et al. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission I. Description of study site, general methodology, and study population. Am J Trop Med Hyg 1999;60:635-640. (Pubitemid 29233122)
46. Waitumbi JN, Opollo MO, Muga RO, et al. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood 2000;95:1481-1486.
47. Awandare GA, Goka B, Boeuf P, et al. Increased levels of inflammatory mediators in children with severe Plasmodium falciparum malaria with respiratory distress. J Infect Dis 2006;194:1438-1446.
48. Lee GR. Anemia: General Aspects. Baltimore: Williams & Wilkins; 1999.
49. Luty AJ, Perkins DJ, Lell B, et al. Low interleukin-12 activity in severe Plasmodium falciparum malaria. Infect Immun 2000;68:3909-3915. (Pubitemid 30434540)
50. Ghosh K. Pathogenesis of anemia in malaria: A concise review. Parasitol Res 2007;101:1463-1469. (Pubitemid 47524866)
51. Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer 2006;46:554-557.
52. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-1276. (Pubitemid 39069926)
53. Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-2463. (Pubitemid 36857598)
54. Mayaux MJ, Burgard M, Teglas JP, et al. Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. The French Pediatric HIV Infection Study Group. JAMA 1996;275:606-610. (Pubitemid 26062798)
55. Rich KC, Fowler MG, Mofenson LM, et al. Maternal and infant factors predicting disease progression in human immunodeficiency virus type 1-infected infants. Women and Infants Transmission Study Group. Pediatrics 2000;105:e8.
56. Nkhoma ET, Poole C, Vannappagari V, et al. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-278.
57. Clark IA, Hunt NH. Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect Immun 1983;39:1-6.
58. Miller J, Golenser J, Spira DT, Kosower NS. Plasmodium falciparum: Thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes. Exp Parasitol 1984;57:239-247.
59. Aidoo M, Terlouw DJ, Kolczak MS, et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 2002;359:1311-1312. (Pubitemid 34310639)
60. Williams TN, Mwangi TW, Wambua S, et al. Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J Infect Dis 2005;192:178-186. (Pubitemid 40863872)
61. Tomas Ganz RIL. William's Hematology. New York: McGraw-Hill; 1995. pp 875-878.
62. Sherry BA, Alava G, Tracey KJ, et al. Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1 alpha, and MIP-1 beta) in vitro, and altered thermoregulation in vivo. J Inflamm 1995;45:85-96.
63. Perkins DJ, Moore JM, Otieno J, et al. In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10. Biochem Biophys Res Commun 2003;311:839-846.
64. Keller CC, Kremsner PG, Hittner JB, et al. Elevated nitric oxide production in children with malarial anemia: Hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. Infect Immun 2004;72:4868-4873.
65. Casals-Pascual C, Kai O, Cheung JO, et al. Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood 2006;108:2569-2577.