Long-term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1/BRCA2/TP53 status

British Journal of Cancer

Volumn 102, Issue 7, 2010, Pages 1091-1098

  Evans, D G R ^a,b   Moran, A ^c   Hartley, R ^c   Dawson, J ^a   Bulman, B ^a   Knox, F ^b   Howell, A ^b,d   Lalloo, F ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

BRCA1; BRCA2; Familial breast cancer; Family history; TP53

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN P53;

ADULT; ARTICLE; BREAST CANCER; CANCER INCIDENCE; CANCER PATIENT; CANCER SURVIVAL; DNA DETERMINATION; FAMILY HISTORY; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; KAPLAN MEIER METHOD; LONG TERM CARE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATHOLOGY; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROBABILITY; SENSITIVITY AND SPECIFICITY;

ADULT; BREAST NEOPLASMS; COHORT STUDIES; ENGLAND; FEMALE; FOLLOW-UP STUDIES; GENES, BRCA1; GENES, BRCA2; GENES, P53; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; MODELS, BIOLOGICAL; MUTATION; SURVIVAL ANALYSIS; SURVIVORS; YOUNG ADULT;

EID: 77950371028     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605606     Document Type: Article

References (27)

1. Anders CK, Hsu DS, Broadwater G, Acharya CR, Foekens JA, Zhang Y, Wang Y, Marcom PK, Marks JR, Febbo PG, Nevins JR, Potti A, Blackwell KL (2008) Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26(20): 3324-3330
2. Antoniou AC, Cunningham AP, Peto J, Evans DG, Lalloo F, Narod SA, Risch HA, Eyfjord JE, Hopper JL, Southey MC, Olsson H, Johannsson O, Borg A, Passini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tryggvadottir L, Syrjakoski K, Kallioniemi OP, Eerola H, Nevanlinna H, Pharoah PD, Easton DF (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. Br J Cancer 45(7): 425-431
3. Bergfeldt K, Rydh B, Granath F, Grönberg H, Thalib L, Adami HO, Hall P (2002) Risk of ovarian cancer in breast-cancer patients with a family history of breast or ovarian cancer: a population-based cohort study. Lancet 360(9337): 891-894
4. Birch JM, Hartley AL, Tricker KJ, Prosser J, Condie A, Kelsey AM, Harris M, Morris-Jones PH, Crowther D, Craft AW, Eden OB, Evans DGR, Thompson E, Mann J, Martin J, Mitchell ELD, Santibanez-Koref MF (1994) Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res 54: 1298-1304
5. Ellis IO, Bartlett J, Dowsett M, Humphreys S, Jasani B, Miller K, Pinder SE, Rhodes A, Walker R (2004) Updated recommendations for Her-2 testing in the UK. J Clin Pathol 57: 233-237
6. Evans DG, Lalloo F, Cramer A, Jones E, Knox F, Amir E, Howell A (2009) Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing. J Med Genet 46(12): 811-817
7. Evans DGR, Eccles DM, Rahman N, Young K, Bulman M, Amir E, Shenton A, Howell A, Lalloo F (2004) A new scoring system for the chances of identifying a BRCA1/2 mutation, outperforms existing models including BRCAPRO. J Med Genet 41(6): 474-480
8. Fentiman IS, Mansel RE (1991) The axilla: not a no-go zone. Lancet 337(8735): 221-223
9. Figueiredo JC, Ennis M, Knight JA, McLaughlin JR, Hood N, O'Malley F, Andrulis IL, Goodwin PJ (2007) Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study. Breast Cancer Res Treat 105(1): 69-80
10. Fitzgerald MG, Macdonald DJ, Krainer M, Hoover I, O'Neil E, Unsal H, Silva-Arrietto S, Finklestein DM, Beer-Romero P, Englert C, Sgroi DC, Smith BL, Younger JW, Garber JE, Duda RB, Mayzel KA, Isselbacher KJ, Friend SH, Haber DA (1996) Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 334: 143-149 (Pubitemid 26017951) (Pubitemid 26017951)
11. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare MD, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Ponder BA, Gayther SA, Zelada-Hedman M and the Breast Cancer Linkage Consortium (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 62: 676-689
12. Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, Gumpper KL, Scholl T, Tavtigian SV, Pruss DR, Critchfield GC (2002) Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 20(6): 1480-1490
13. Gayther SA, Pharoah PDP, Ponder BAJ (1998) The genetics of inherited breast cancer. J Mamm Gland Biol Neopasia 3: 365-376
14. Han W, Kang SY, The Korean Breast Cancer Society (2010) Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer. Breast Cancer Res Treat 119(1): 193-200
15. Jmor S, Al-Sayer H, Heys SD, Payne S, Miller I, Ah-See A, Hutcheon A, Eremin O (2002) Breast cancer in women aged 35 and under: prognosis and survival. J R Coll Surg Edinb 47(5): 693-699
16. Krainer M, Silva-Arrieta S, Fitzgerald MG, Shiminda A, Ishoka C, Kanamuru R, Macdonald DJ, Unsal H, Finklestein DM, Bowcock A, Isselbacher KJ, Haber DA (1997) Differential contributions of BRCA1 and BRCA2 to early onset breast cancer. N Engl J Med 336: 1416-1421 (Pubitemid 27208600) (Pubitemid 27208600)
17. Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van der Vijver M, Parry S, Bishop T, Benitez J, Rivas C, Bignon YJ, Chang-Claude J, Hamann U, Cornelisse CJ, Devilee P, Beckmann MW, Nestle-Kramling C, Daly PA, Haites N, Varley J, Lalloo F, Evans G, Maugard C, Meijers-Heijboer H, Klijn JG, Olah E, Gusterson BA, Pilotti S, Radice P, Scherneck S, Sobol H, Jacquemier J, Wagner T, Peto J, Stratton MR, McGuffog L, Easton DF, Breast Cancer Linkage Consortium (2005) Breast Cancer Linkage Consortium. Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clin Cancer Res 11(14): 5175-5180
18. Lalloo F, Varley J, Ellis D, Moran A, O'Dair L, Pharoah P, Evans DG (2003) Prediction of pathogenic mutations in patients with early-onset breast cancer by family history. Lancet 361: 1101-1102
19. Lalloo F, Varley J, Moran A, Ellis D, O'Dair L, Pharoah P, Antoniou A, Hartley R, Shenton A, Seal S, Bulman B, Howell A, Evans DG (2006) BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. Eur J Cancer 42(8): 1143-1150
20. Li FP, Fraumeni JF, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA, Miller RW (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res 48: 5358-5362
21. Loman N, Johannsson O, Kristoffersson U, Olsson H, Borg A (2001) Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early onset breast cancer. J Natl Cancer Inst 93: 1215-1223
22. Nixon AJ, Neuberg D, Hayes DF, Gelman R, Connolly JL, Schnitt S, Abner A, Recht A, Vicini F, Harris JR (1994) Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol 12(5): 888-894 (Pubitemid 24145313) (Pubitemid 24145313)
23. Parmigiani G, Berry DA, Aquilar O (1998) Determining carrier probabilities for breast cancer susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 62: 145-148
24. Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, Easton DF, Evans C, Deacon J, Stratton MR (1999) Prevalence of BRCA1 and BRCA2 gene mutations in patients with early onset breast cancer. J Natl Cancer Inst 91: 943-949
25. Sidransky D, Tokino T, Helzlsouer K, Zehnbauer B, Rausch G, Shelton B, Prestigiacomo L, Vogelstein B, Davidson N (1992) Inherited p53 gene mutations in breast cancer. Cancer Res 52: 2984-2986
26. Varley J, McGown G, Thorncroft M, Santibanez-Koref MF, Kelsey AM, Tricker KJ, Evans DGR, Birch JM (1997) Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families. Cancer Res 14: 865-871
27. Young SR, Pilarski RT, Donenberg T, Shapiro C, Hammond LS, Miller J, Brooks KA, Cohen S, Tenenholz B, Desai D, Zandvakili I, Royer R, Li S, Narod SA (2009) The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. BMC Cancer 9: 86