Effects of formalin fixing on the terahertz properties of biological tissues

Journal of Biomedical Optics

Volumn 14, Issue 6, 2009, Pages

  Sun, Yiwen ^a   Fischer, Bernd M ^b,c   Pickwell MacPherson, Emma ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c FRENCH GERMAN RESEARCH INSTITUTE OF SAINT LOUIS   (France)

Author keywords

Biological samples; Formalin fixed; Frequency domain; Terahertz pulsed imaging; Terahertz spectroscopy; Time domain

Indexed keywords

BIOLOGICAL SAMPLES; FORMALIN-FIXED; FREQUENCY DOMAINS; TERA HERTZ; TERAHERTZ PULSED IMAGING; TIME DOMAIN;

FORMALDEHYDE; REFRACTIVE INDEX; TERAHERTZ WAVES; TISSUE;

TERAHERTZ SPECTROSCOPY;

SUS;

FORMALDEHYDE;

ADIPOSE TISSUE; ANIMAL; ARTICLE; CHEMISTRY; FOURIER ANALYSIS; HISTOLOGY; METHODOLOGY; REFRACTOMETRY; SKELETAL MUSCLE; SWINE; TERAHERTZ IMAGING; TERAHERTZ SPECTROSCOPY; TISSUE FIXATION;

ADIPOSE TISSUE; ANIMALS; FORMALDEHYDE; FOURIER ANALYSIS; MUSCLE, SKELETAL; REFRACTOMETRY; SWINE; TERAHERTZ IMAGING; TERAHERTZ SPECTROSCOPY; TISSUE FIXATION;

EID: 77950365626     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3268439     Document Type: Article

References (37)

1. D. H. Auston, "Picosecond optoelectronic switching and gating in silicon," Appl. Phys. Lett. 26, 101-103 (1975).
2. P. F. Taday, I. V. Bradley, D. D. Arnone, and M. Pepper, "Using terahertz pulse spectroscopy to study the crystalline structure of a drug: A case study of the polymorphs of ranitidine hydrochloride," J. Pharm. Sci., 92 (4), 831-838 (2003). (Pubitemid 36396998)
3. V. P. Wallace, P. F. Taday, A. J. Fitzgerald, R. M. Woodward, J. Cluff, R. J. Pyeand, and D. D. Arnone, "Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications," Faraday Discuss. 126, 255-263 (2004). (Pubitemid 38365598)
4. E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. Lynch, and M. Pepper, "A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro," Caries Res., 41, 49-55 (2007).
5. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulse imaging of ex vivo basal cell carcinoma," J. Invest. Dermatol., 120, 72-78 (2003). (Pubitemid 36120973)
6. A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, and D. D. Arnone, "Terahertz pulsed imaging of human breast tumors," Radiology, 239, 533-540 (2006).
7. Y. C. Shen, T. Lo, P. F. Taday, B. E. Cole, W. R. Tribe, and M. C. Kemp, "Detection and identification of explosives using terahertz pulsed spectroscopic imaging," Appl. Phys. Lett. 86 (24), 241116 (2005).
8. M. C. Beard, G. M. Turner, and C. A. Schmuttenmaer, "Terahertz spectroscopy," J. Phys. Chem. B 106, 7146-7159 (2002). (Pubitemid 35383038)
9. R. H. Clothier and N. Bourne, "Effects of THz exposure on human primary keratinocyte differentiation and viability," J. Biol. Phys. 29, 179-185 (2003). (Pubitemid 36876517)
10. J. T. Kindt and C. A. Schmuttenmaer, "Far-Infrared dielectric properties of polar liquids probed by femtosecond terahertz pulse spectroscopy," J. Phys. Chem. 100, 10373-10379 (1996). (Pubitemid 126789365)
11. K. J. Tielrooij, R. L. A. Timmer, H. J. Bakker, and M. Bonn, "Structure dynamics of the proton in liquid water probed with terahertz time-domain spectroscopy," Phys. Rev. Lett. 102, 198303 (2009).
12. W. Withayachumnankul, G. M. Png, X. X. Yin, S. Atakaramians, I. Jones, L. Hungyen, B. Seam Yu Ung, J. Balakrishnan, W. H. Brian Ng, B. Ferguson, S. P. Mickan, B. M. Fischer, and D. Abbott, "T-Ray sensing and imaging," in Proc. IEEE Vol. 95, pp. 1528-1558 (2007).
13. C. J. Strachan, P. F. Taday, D. A. Newnham, K. C. Gordon, J. A. Zeitler, M. Pepper, and T. Rades, "Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity," J. Pharm. Sci., 94, 837-846 (2005). (Pubitemid 40577316)
14. D. M. Mittleman, M. C. Nuss, and V. L. Colvin, "Terahertz spectroscopy of water in inverse micelles," Chem. Phys. Lett., 275, 332-338 (1997). (Pubitemid 127166101)
15. M. Walther, B. M. Fischer, M. Schall, H. Helm, and P. U. Jepsen, "Far-infrared vibrational spectra of all-trans 9-cis and 13-cis retinal measured by THz time-domain spectroscopy," Chem. Phys. Lett., 332, 389-395 (2000).
16. B. M. Fischer, M. Hoffmann, H. Helm, R. Wilk, F. Rutz, T. Kleine- Ostmann, M. Koch, and P. U. Jepsen, "Terahertz time-domain spec- troscopy and imaging of artificial RNA," Opt. Express 13, 5205-5215 (2005). (Pubitemid 41029272)
17. B. M. Fischer, H. Helm, and P. U. Jepsen, "Chemical recognition with broadband THz spectroscopy," in Proc. IEEE Vol. 95, pp. S246- S253 (2007).
18. R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulsed imaging of skin cancer in the time and frequency domain," J. Biol. Phys. 29, 257-261 (2003). (Pubitemid 36876525)
19. E. Pickwell, V. P. Wallace, A. J. Fitzgerald, B. E. Cole, R. J. Pye, T. Ha, and M. Pepper, "Simulating the response of terahertz radiation to human skin using ex vivo spectroscopy measurements," J. Biomed. Opt. 10, 064021 (2005).
20. V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, "Terahertz pulsed spectroscopy of human basal cell carcinoma," Appl. Spectrosc. 60, 1127-1133 (2006). (Pubitemid 44599989)
21. S. Y. Huang, Y. X. J. Wang, D. K. W. Yeung, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, "Tissue characterisation using terahertz pulsed imaging in reflection geometry," Phys. Med. Biol. 54, 149-160 (2009).
22. R. C. Grafstrom, A. Fornace, Jr., and C. C. Harris, "Repair of DNA damage caused by formaldehyde in human cells," Cancer Res. 44, 4323-4327 (1984). (Pubitemid 14008743)
23. P. Knobloch, K. Schmalstieg, M. Koch, E. Rehberg, F. Vauti, and K. Donhuijsend, "THz imaging of histo-pathological samples," Proc. SPIE 4434, 239-245 (2001).
24. E. Pickwell, "Biological applications of terahertz pulsed imaging and spectroscopy," Ph.D. Thesis, Cambridge Univ. (2005).
25. E. Pickwell, B. E. Cole, A. J. Fitzgerald, M. Pepper, and V. P. Wallace, "In vivo study of human skin using pulsed terahertz radiation," Phys. Med. Biol. 49, 1595-1607 (2004). (Pubitemid 38678703)
26. S. Y. Huang, E. Pickwell-Macpherson, and Y. T. Zhang, "A new data processing scheme to reduce variations in terahertz pulsed imaging," in Proc. of Int. Workshop on Wearable and Implantable Body Sensor Networks (BSN 2008), with 5th Int. Summer School and Symp. On Medical Devices and Biosensors, Hong Kong, pp. 236-239, IEEE, Piscataway, NJ (2008).
27. D. M. Mittleman, Sensing with Terahertz Radiation, Springer, Berlin (2003).
28. B. E. Cole, R. Woodward, D. Crawley, V. P. Wallace, D. D. Arnone, and M. Pepper, "Terahertz imaging and spectroscopy of human skin, in vivo," Proc. SPIE 4276, 1-10 (2001). (Pubitemid 32795946)
29. M. H. Hofker and J. V. Deursen, Methods in Molecular Biology, Humana Press, NJ (2002).
30. L. C. Junqueira, Basic Histology: Text & Atlas, McGraw-Hill, New York (2005).
31. D. W. Cromey, Formaldehyde fixatives, Southwest Environmental Health Sciences Center, Univ. of Arizona (2004).
32. L. Johannes and V. H. Robert, Applied Statistics for Engineers and Physical Scientists, Prentice Hall, Englewood Cliffs, NJ (2009).
33. M. R. Stringer, D. N. Lund, A. P. Foulds, A. Uddin, E. Berry, R. E. Miles1, and A. G. Davies, "The analysis of human cortical bone by terahertz time-domain spectroscopy," Phys. Med. Biol. 50, 3211-3219 (2005). (Pubitemid 40991684)
34. C. L. Nie, W. Zhang, D. Zhang, and R. Q. He, "Changes in conformation of human neuronal tau during denaturation in formaldehyde solution," Protein Peptide Lett. 12, 75-78 (2005). (Pubitemid 40068362)
35. J. F. Walker, Formaldehyde, Reinhold, New York (1964).
36. C. H. Fox, F. B. Johnson, J. Whiting, and P. P. Roller, "Formaldehyde fixation," J. Histochem. Cytochem. 33, 845-853 (1985).
37. A. Younge, C. F. Van Niekerk, and S. Mogotlane, Juta's Manual of Nursing, Juta & Co., Cape Town, South Africa (2003).