Terahertz pulsed imaging of human breast tumors

Radiology

Volumn 239, Issue 2, 2006, Pages 533-540

  Fitzgerald, Anthony J ^a   Wallace, Vincent P ^a   Jimenez Linan, Mercedes ^b   Bobrow, Lynda ^b   Pye, Richard J ^c   Purushotham, Anand D ^b   Arnone, Donald D ^a  

^a TERAVIEW LTD   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c BUPA Hospitals   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; APPARATUS; ARTICLE; BREAST CARCINOMA; BREAST DUCTAL CARCINOMA; BREAST TUMOR; CANCER INVASION; CORRELATION COEFFICIENT; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; FEASIBILITY STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGING SYSTEM; MICROPHOTOGRAPHY; PARAMETER; PRIORITY JOURNAL; RADIOLOGY; TERAHERTZ PULSED IMAGING; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEASIBILITY STUDIES; FEMALE; HUMANS; MIDDLE AGED; RADIO WAVES;

EID: 33646129691     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2392041315     Document Type: Article

References (32)

1. Grischkowsky D, Keiding S, van Exter M, Fattinger C. Far-infrared time-domain spectroscopy with terahertz beams of dielectrics and semiconductors. J Opt Soc Am B Opt Phys 1990;7:2006-2015.
2. Han PY, Cho GC, Zhang XC. Time-domain transillumination of biological tissues with terahertz pulses. Opt Lett 2000;25:242-244.
3. Fitzgerald AJ, Cole BE, Taday PF. Analysis of tablet coaling thickness, uniformity and integrity using terahertz pulsed imaging. J Pharm Sci 2005;94:177-183.
4. Clothier RH, Bourn N. Effects of exposure on human primary keratinocyte differentiation and viability. J Biol Phys 2003;29:179-185.
5. Berry E, Walker GC, Fitzgerald AJ, et al. Do in vivo terahertz imaging systems comply with safety guidelines? J Laser App 2003;15: 192-198.
6. Mittleman DM, Jacobsen RH, Nuss MC. T-ray imaging. IEEE J Sel Top Quant Electr 1996;2:679-692.
7. Smye SW, Chamberlain JM, Fitzgerald AJ, Berry E. The interaction between terahertz radiation and biological tissue. Phys Med Biol 2001;46:R101-R112.
8. Brucherseifer M, Nagel M, Haring-Bolivar P, Kurz H. Label-free probing of the binding state of DNA by time-domain terahertz sensing. Appl Phys Lett 2000;77:4049-4051.
9. Markelz AG, Roitberg A, Heilweil EJ. Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 Terahertz. Chem Phys Lett. 2000;320: 42-48.
10. Walther M, Fischer B, Schall M, Helm H, Jepsen UP. Far-infrared vibrational spectra of all-trans, 9-cis, and 13-cis retinal measured by terahertz time-domain spectroscopy. Chem Phys Lett 2000;332:389-395.
11. Woodward RM, Wallace VP, Pye RJ, et al. Terahertz pulse imaging of ex vivo basal cell carcinoma. J Invest Dermatol 2003;120:72-78.
12. Wallace VP, Taday PF, Fitzgerald AJ. Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications. Faraday Discuss 2004;126:255-264.
13. Wallace VP, Fitzgerald AJ, Shankar S, Pye RJ, Arnone DD. Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo. Br J Dermatol 2004;151:424-432.
14. Harris JR, Lippmann ME, Morrow M, Osbourne KC, eds. Diseases of the breast, 2nd ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2004.
15. Mittleman DM, Hunsche S, Boivin L, Nuss MC. T-ray tomography. Opt Lett 1997;22: 904-906.
16. Cole BF, Woodward RM, Crawley D. Terahertz imaging and spectroscopy of human skin in vivo. In: Haglund RF, Neev J, Wood RF, eds. Proceedings of SPIE: medical imaging 2001 - commercial and biomedical applications of ultrashort pulse lasers: laser plasma generation and diagnostics. Vol 4276. Bellingham, Wash: International Society for Optical Engineering, 2001; 1-10.
17. Boulter C, Mulroy S, Webb S, Fleming S, Brindle K, Sandford R. Cardiovascular, skeletal and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A 2001;98:12174-12179.
18. 76Br-bromide and PET. J Nucl Med 2003;44:1210-1218.
19. Ross KF, Gordon RE. Water in malignant tissue, measured by cell refractometry, and nuclear magnetic resonance. J Microsc 1982;128:7-12.
20. Chen JH, Avram HE, Crooks LE, Arakawa M, Kaufman L, Briton AC. In vivo relaxation times and hydrogen density at 0.063-4.85 T in rats with implanted mammary adenocarcinomas. Radiology 1992;184:427-434.
21. Rofstad EK, Steinsland E, Kaalhus O, Chang YB, Hovik B, Lyng H. Magnetic resonance imaging of human melanoma xenographs in vivo: proton spin lattice and spin-spin relaxation times versus fractional water content and fraction of necrotic tumour tissue. Int J Radiat Biol 1994;65:387-401.
22. Jakubowski DB, Cerussi AE, Beilacqua F, et al. Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. J Biomed Opt 2004;9(1):230-238.
23. Thrane L, Jacobsen RH, Uhd Jepsen P, Keiding SR. THz reflection spectroscopy of liquid water. Chem Phys Lett 1995;240:330-333.
24. 2O in the far IR region. J Mol Struct 1995;350: 95-114.
25. Fitzgerald AJ, Berry B, Zinv'ev NN, et al. Catalogue of human tissue optical properties at terahertz frequencies. J Biol Phys 2003; 129:123-128.
26. Knobloch P, Schildknecht C, Klience-Ostmann T, et al. Medical terahertz imaging: an investigation of histo-pathological samples. Phys Med Biol 2002;47:3875-3884.
27. Loffler T, Siebert K, Czasch S, Bauer T, Roskos HG. Visualisation and classification in biomedical terahertz pulsed imaging. Phys Med Biol 2002;47:3847-3852.
28. Berry E, Handley JW, Fitzgerald AJ, et al. Multispectral classification techniques for terahertz pulsed imaging: an example in histopathology. Med Eng Phys 2004;26:423-430.
29. Pickwell E, Cole BE, Fitzgerald AJ, Pepper M, Wallace VP. Simulation of terahertz pulse propagation in biological systems. Appl Phys Lett 2004;84:2190-2192.
30. Pickwell E, Cole BE, Fitzgerald AJ, Pepper M, Wallace VP. In vivo study of human skin using pulsed terahertz radiation. Phys Med Biol 2004;49:1595-1607.
31. Bolan PJ, Meisamy S, Baker EH, et al. In vivo quantification of choline compounds in the breast with 1H MR spectroscopy. Magn Reson Med 2003;50:1134-1143.
32. Boppart SA, Luo W, Marks DL, Singletary KW. Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer. Breast Cancer Res Treat 2004;84:85-97.