Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: Pilot human study

Journal of Biomedical Optics

Volumn 14, Issue 6, 2009, Pages

  Papazoglou, Elisabeth S ^a   Neidrauer, Michael ^a   Zubkov, Leonid ^a   Weingarten, Michael S ^b   Pourrezaei, Kambiz ^a  

^a DREXEL UNIVERSITY   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Chronic diabetic foot ulcers; Deoxygenated hemoglobin; Diffuse photon density wave; Frequency domain near infrared spectroscopy; Optical absorption coefficient; Oxygenated hemoglobin; Wound healing

Indexed keywords

DEOXYGENATED HEMOGLOBIN; DIABETIC FOOT ULCER; DIFFUSE PHOTON DENSITY WAVES; FREQUENCY DOMAINS; OPTICAL ABSORPTION COEFFICIENT; OXYGENATED HEMOGLOBIN; WOUND HEALING;

ABSORPTION; CONCENTRATION (PROCESS); FREQUENCY DOMAIN ANALYSIS; HEMOGLOBIN; INFRARED DEVICES; INFRARED SPECTROSCOPY; LIGHT ABSORPTION; PHOTONS; TISSUE;

DISEASES;

DEOXYHEMOGLOBIN; HEMOGLOBIN; OXYHEMOGLOBIN;

ABSORPTION; ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL TRIAL; DIABETES MELLITUS; DIABETIC FOOT; HUMAN; METABOLISM; METHODOLOGY; MIDDLE AGED; NEAR INFRARED SPECTROSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY; PREDICTION AND FORECASTING; WOUND HEALING;

ABSORPTION; ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; DIABETES MELLITUS; DIABETIC FOOT; HEMOGLOBINS; HUMANS; MIDDLE AGED; OXYHEMOGLOBINS; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; SPECTROSCOPY, NEAR-INFRARED; WOUND HEALING;

EID: 77950355595     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3275467     Document Type: Article

References (34)

1. R. G. Sibbald, H. L. Orsted, P. M. Coutts, and D. H. Keast, "Best practice recommendations for preparing the wound bed: update 2006," Adv. Skin Wound Care, 20(7), 390-405 (2007).
2. R. J. Goldman and R. Salcido, "More than one way to measure a wound: an overview of tools and techniques," Adv. Skin Wound Care 15(5), 236-243 (2002).
3. N. Cullum, E. A. Nelson, K. Flemming, and T. Sheldon, "Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy," Health Technol. Assess 5(9), 1-221 (2001).
4. T. Mustoe, "Dermal ulcer healing: advances in understanding," in Proc. Tissue Repair and Ulcer/Wound Healing: Molecular Mechanisms, Therapeutic Targets and Future Directions, Paris, March 17-18, 2005, Institute Louis Pasteur, Paris (2005).
5. T. Gambichler, G. Moussa, M. Sand, D. Sand, P. Altmeyer, and K. Hoffmann, "Applications of optical coherence tomography in dermatology," J. Dermatol. Sci. 40(2), 85-94 (2005). (Pubitemid 41446206)
6. R. R. Anderson and J. A. Parrish, "The optics of human skin," J. Invest. Dermatol. 77(1), 13-19 (1981). (Pubitemid 12229295)
7. M. G. Rippon, K. Springett, and R. Walmsley, "Ultrasound evaluation of acute experimental and chronic clinical wounds," Skin Res. Technol. 5(4), 228-236 (1999). (Pubitemid 29504972)
8. O. Timar-Banu, H. Beauregard, J. Tousignant, M. Lassonde, P. Harris, G. Viau, L. Vachon, E. Levy, and T. Abribat, "Development of noninvasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans," Wound Repair Regen 9(2), 123-132 (2001). (Pubitemid 32458319)
9. M. Dyson, S. Moodley, L. Verjee, W. Verling, J. Weinman, and P. Wilson, "Wound healing assessment using 20 MHz ultrasound and photography," Skin Res. Technol. 9, 116-121 (2003). (Pubitemid 36603654)
10. M. J. Cobb, Y. Chen, R. A. Underwood, M. L. Usui, J. Olerud, and X. Li, "Noninvasive assessment of cutaneous wound healing usingultrahigh- resolution optical coherence tomography," J. Biomed. Opt. 11, 064002 (2006).
11. J. T. Oh, S. W. Lee, Y. S. Kim, K. B. Suhr, and B. M. Kim, "Quantification of the wound healing using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 11, 041124 (2006).
12. F. Khan and D. J. Newton, "Laser Doppler imaging in the investigation of lower limb wounds," Int. J. Lower Extremity Wounds 2(2), 74 (2003).
13. M. E. Gschwandtner, E. Ambrozy, S. Fasching, A. Willfort, B. Schneider, K. Bohler, U. Gaggl, and H. Ehringer, "Microcirculation in venous ulcers and the surrounding skin: findings with capillary microscopy and a laser Doppler imager," Eur. J. Clin. Invest 29(8), 708 (1999).
14. B. Mlacak, A. Blinc, N. Gale, and B. Ivka, "Microcirculation disturbances in patients with venous ulcer before and after healing as assessed by laser Doppler flux-metry," Arch. Med. Res. 36(5), 480-484 (2005). (Pubitemid 41140052)
15. W. D. Schmidt, K. Liebold, D. Fassler, and U. Wollina, "Contact-free spectroscopy of leg ulcers: principle, technique, and calculation of spectroscopic wound scores," J. Invest. Dermatol. 116, 531-535 (2001). (Pubitemid 32299841)
16. U. Wollina, K. Liebold, W. D. D. Schmidt, M. D. Hartmann, and D. D. Fassler, "Biosurgery supports granulation and debridement in chronic wounds-clinical data and remittance spectroscopy measurement," Int. J. Dermatol. 41(10), 635-639 (2002). (Pubitemid 35252036)
17. S. M. Rajbhandari, N. D. Harris, S. Tesfaye, and J. D. Ward, "Early identification of diabetic foot ulcers that may require intervention using the micro lightguide spectrophotometer," Diabetes Care 22(8), 1292-1295 (1999). (Pubitemid 29350239)
18. J. R. Payette, E. Kohlenberg, L. Leonardi, A. Pabbies, P. Kerr, K. Z. Liu, and M. G. Sowa, "Assessment of skin flaps using optically based methods for measuring blood flow and oxygenation," Plast. Reconstr. Surg. 115(2), 539-546 (2005). (Pubitemid 40279314)
19. E. K. Yeong, T. C. Hsiao, H. K. Chiang, and C. W. Lin, "Prediction of burn healing time using artificial neural networks and reflectance spectrometer," Burns 31(4), 415-420 (2005).
20. J. Mobley and T. Vo-Dinh, "Optical properties of tissue," in Biomedical Photonics Handbook, CRC Press, Boca Raton, FL (2003).
21. E. S. Papazoglou, M. S. Weingarten, L. Zubkov, L. Zhu, S. Tyagi, and K. Pourrezaei, "Optical properties of wounds: diabetic versus healthy tissue," IEEE Trans. Biomed. Eng. 53(6), 1047-1055 (2006). (Pubitemid 43860728)
22. E. S. Papazoglou, M. S. Weingarten, L. Zubkov, M. Neidrauer, L. Zhu, S. Tyagi, and K. Pourrezaei, "Changes in optical properties of tissue during acute wound healing in an animal model," J. Biomed. Opt. 13(4), 044005. (2008).
23. S. L. Jacques and B. W. Pogue, "Tutorial on diffuse light transport," J. Biomed. Opt. 13, 041302 (2008).
24. A. G. Yodh and D. A. Boas, "Functional imaging with diffusing light," in Biomedical Photonics Handbook, CRC Press, Boca Raton, FL (2003).
25. T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500 (2000).
26. N. Shah, A. E. Cerussi, D. Jakubowski, D. Hsiang, J. Butler, and B. J. Tromberg, "Spatial variations in optical and physiological properties of healthy breast tissue," J. Biomed. Opt. 9(3), 534-540 (2004).
27. S. Prahl, Optical Absorption of Hemoglobin, see http://omlc.ogi.edu/ spectra/hemoglobin/, Oregon Medical Laser Center, Portland, OR (1999).
28. G. M. Hale and M. R. Querry, "Optical constants of water in the 200-nm to 200-micrometer wavelength region," Appl. Opt. 12(3), 555 (1973).
29. T. Svensson, S. Andersson-Engels, M. Einarsdóttír, and K. Svanberg, "In vivo optical characterization of human prostate tissue using nearinfrared time-resolved spectroscopy," J. Biomed. Opt. 12, 014022 (2007).
30. A. J. Singer and R. A. F. Clark, "Cutaneous wound healing," N. Engl. J. Med. 341(10), 738-746 (1999). (Pubitemid 29407375)
31. V. Falanga, "Wound healing and its impairment in the diabetic foot," Lancet 366(9498), 1736-1743 (2005). (Pubitemid 41587454)
32. M. A. M. Loots, E. N. Lamme, J. Zeegelaar, J. R. Mekkes, J. D. Bos, and E. Middelkoop, "Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds," J. Invest. Dermatol. 111(5), 850-857 (1998). (Pubitemid 28509329)
33. A. Veves, C. M. Akbari, J. Primavera, V. M. Donaghue, D. Zacharoulis, J. S. Chrzan, U. DeGirolami, F. W. LoGerfo, and R. Freeman, "Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration," Diabetes 47(3), 457 (1998).
34. T. A. Mustoe, K. O'Shaughnessy, and O. Kloeters, "Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis," Plast. Reconstr. Surg. 117(7S), 35S (2006).