Platelet-derived growth factor acts via both the Rho-kinase and p38 signaling enzymes to stimulate contraction in an in vitro model of equine wound healing

Domestic Animal Endocrinology

Volumn 38, Issue 4, 2010, Pages 253-259

  Watts, E J ^a   Rose, M T ^a  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

equine fibroblasts; insulin like growth factor 1; platelet derived growth factor; Rho kinase; transforming growth factor 1; wound contraction

Indexed keywords

ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; RHO KINASE; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CELL MOTION; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; HORSE; MOUTH MUCOSA; PHYSIOLOGY; SIGNAL TRANSDUCTION; WOUND HEALING;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; ENZYME INHIBITORS; FIBROBLASTS; HORSES; INSULIN-LIKE GROWTH FACTOR I; MODELS, BIOLOGICAL; MOUTH MUCOSA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET-DERIVED GROWTH FACTOR; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EQUIDAE;

EID: 77950340081     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2009.11.004     Document Type: Article

References (38)

1. Wilmink J.M., and van Weeren P.R. Second-intention repair in the horse and pony and management of exuberant granulation tissue. Vet Clin North Am Equine Pract. 21 (2005) 15-32
2. Knottenbelt D.C. Equine wound management: are there significant differences in healing at different sites on the body?. Vet Dermatol. 8 (1997) 273-290
3. Hakkinen L., Uitto V.J., and Larjava H. Cell biology of gingival wound healing. Periodontol. 24 (2000) 127-152
4. Wilmink J.M., Nederbragt H., van Weeren P.R., Stolk P.W., and Barneveld A. Differences in wound contraction between horses and ponies: the in vitro contraction capacity of fibroblasts. Equine Vet J. 33 (2001) 499-505
5. Ehrlich H., Sun B., Kainth K.S., and Kromah F. Elucidating the mechanism of wound contraction: rapid versus sustained myosin ATPase activity in attached-delayed-released compared with free-floating fibroblast-populated collagen lattices. Wound Repair Regen. 14 (2006) 625-632
6. Theoret C.L. The pathophysiology of wound repair. Vet Clin North Am Equine Pract. 21 (2001) 1-13
7. Li S., Moon J.J., Miao H., et al. Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix. J Vasc Res. 40 (2003) 378-388
8. Tamariz E., and Grinnell F. Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell. 13 (2002) 3915-3929
9. Hirano S., Rees R.S., and Gilmont R.R. MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction. J Surg Res. 102 (2002) 77-84
10. Hinz B. Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission. Eur J Cell Biol. 85 (2006) 175-181
11. Serini G., Bochaton-Piallat M.L., Ropraz P., et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol. 142 (1998) 873-881
12. Chipev C.C., and Simon M. Phenotypic differences between dermal fibroblasts from different body sites determine their responses to tension and TGFbeta1. BMC Dermatol. 2 (2002) 13
13. Goffin J.M., Pittet P., Csucs G., Lussi J.W., Meister J.J., and Hinz B. Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol. 172 (2002) 259-268
14. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 124 (1994) 401-404
15. Arora P.D., Narani N., and Mcculloch C.A. The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts. Am J Pathol. 154 (1999) 871-882
16. Andresen J.L., Ledet T., and Ehlers N. Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res. 16 (1997) 605-613
17. Lee Y.R., Oshita Y., Tsuboi R., and Ogawa H. Combination of insulin-like growth factor (IGF)-I and IGF-binding protein-1 promotes fibroblast-embedded collagen gel contraction. Endocrinology. 137 (1996) 5278-5283
18. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 351 (2000) 95-105
19. Assouline M., Chew S.J., Thompson H.W., and Beuerman R. Effect of growth factors on collagen lattice contraction by human keratocytes. Invest Ophthalmol Vis Sci. 133 (1992) 1742-1755
20. Clark R.A. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol. 94 (1990) 128S-134S
21. Jeschke M.G., Schubert T., Krickhahn M., et al. Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds. Wound Repair Regen. 13 (2005) 269-277
22. Edmondson S.R., Thumiger S.P., Werther G.A., and Wraight C.J. Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev. 24 (2003) 737-764
23. Kanekar S., Borg T.K., Terracio L., and Carver W. Modulation of heart fibroblast migration and collagen gel contraction by IGF-I. Cell Adhes Commun. 7 (2000) 513-523
24. Tomasek J.J., Gabbiani G., Hinz B., Chaponnier C., and Brown R.A. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 3 (2002) 349-363
25. Ellis I.R., and Schor S.L. Differential motogenic and biosynthetic response of fetal and adult skin fibroblasts to TGF-beta isoforms. Cytokine. 10 (1998) 281-289
26. Montesano R., and Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A. 85 (1988) 4894-4897
27. Haber M., Cao Z., Panjwani N., Bedenice D., Li W.W., and Provost P.J. Effects of growth factors (EGF. PDGF-BB and TGF-beta 1) on cultured equine epithelial cells and keratocytes: implications for wound healing. Vet Ophthalmol. 6 (2003) 211-217
28. Cochrane C.A., Freeman K.L., and Knottenbelt D.C. Effect of growth factors on the characteristics of cells associated with equine wound healing and sarcoid formation. Wound Repair Regen. 4 (1996) 58-65
29. Nixon A.J., Brower-Toland B.D., and Sandell L.J. Molecular cloning of equine transforming growth factor-beta1 reveals equine-specific amino acid substitutions in the mature peptide sequence. J Mol Endocrinol. 24 (2000) 261-272
30. Lee H.G., and Eun H.C. Differences between fibroblasts cultured from oral mucosa and normal skin: implication to wound healing. J Dermatol Sci. 21 (1999) 176-182
31. Hall A., and Rho. GTPases and the control of cell behaviour. Biochem Soc Trans. 33 (2005) 891-895
32. Hotchin N.A., and Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol. 131 (1995) 1857-1865
33. Hinz B., and Gabbiani G. Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol. 14 (2003) 538-546
34. Bhadriraju K., Yang M., Alom Ruiz S., Pirone D., Tan J., and Chen C.S. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 313 (2007) 3616-3623
35. Grinnell F. Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading. Trends Cell Biol. 10 (2000) 362-365
36. Amano M., Kaneko T., Maeda A., et al. Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem. 87 (2003) 780-790
37. Ehrlich H.P., and Rittenberg T. Differences in the mechanism for high- versus moderate-density fibroblast-populated collagen lattice contraction. J Cell Physiol. 185 (2000) 432-439
38. Darenfed H., Dayanandan B., Zhang T., Hsieh S.H., Fournier A.E., and Mandato C.A. Molecular characterization of the effects of Y-27632. Cell Motil Cytoskeleton. 64 (2007) 97-109