T-786C Polymorphism in Promoter of eNOS Gene as Genetic Risk Factor in Patients With Erectile Dysfunction in Turkish Population

Urology

Volumn 75, Issue 4, 2010, Pages 955-960

  Sinici, Incilay ^a   Güven, E Oǧuz ^b   Şerefoǧlu, Egecan ^c   Hayran, Mutlu ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b MUSTAFA KEMAL UNIVERSITY   (Turkey)

^c Ataturk Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DOPPLER ECHOGRAPHY; ERECTILE DYSFUNCTION; GENE; GENETIC RISK; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; RISK; TANDEM REPEAT; TURKEY (REPUBLIC);

HUMANS; IMPOTENCE, VASCULOGENIC; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; TURKEY;

EID: 77950301044     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2009.06.063     Document Type: Article

References (30)

1. Rajfer J., Aronson W.J., Bush P.A., et al. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic eurotransmission. N Engl J Med 326 (1992) 90-94
2. Burnett A.L., Lowenstein C.J., Bredt D.S., et al. Nitric oxide: a physiologic mediator of penile erection. Science 257 (1992) 401
3. Hurt K.J., Musicki B., Palese M.A., et al. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A 99 (2002) 4061-4066
4. Musicki B., and Burnett A.L. eNOS function and dysfunction in the penis. Exp Biol Med (Maywood) 231 (2006) 154-165
5. Janssens S.P., Shimouchi A., Quertermous T., et al. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267 (1992) 14519-14522
6. Marsden P.A., Heng H.H., Scherer S.W., et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268 (1993) 17478-17488
7. Cooke G.E., Doshi A., and Binkley P.F. Endothelial nitric oxide synthase gene: prospects for treatment of heart disease. Pharmacogenomics 8 (2007) 1723-1734
8. Leighton F., Miranda-Rottmann S., and Urquiaga I. A central role of eNOS in the protective effect of wine against metabolic syndrome. Cell Biochem Funct 24 (2006) 291-298
9. Nishijima T., Nakayama M., Yoshimura M., et al. The endothelial nitric oxide synthase gene -786 T/C polymorphism is a predictive factor for reattacks of coronary spasm. Pharmacogenet Genomics 17 (2007) 581-587
10. Song J., Yoon Y., Park K.U., et al. Genotype-specific influence on nitric oxide synthase gene expression, protein concentrations, and enzyme activity in cultured human endothelial cells. Clin Chem 49 6 Pt. 1 (2003) 847-852
11. Wang M.M. Genetics of ischemic stroke: future clinical applications. Semin Neurol 26 (2006) 523-530
12. Miyamoto Y., Saito Y., Nakayama M., et al. Replication protein A1 reduced transcription of the endothelial nitric oxide synthase gene containing a -786T-C mutation associated with coronary spastic angina. Hum Mol Genet 9 (2000) 2629-2637
13. Nakayama M., Yasue H., Yoshimura M., et al. T-786->C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99 (1999) 2864-2870
14. Shabsigh R., and Anastasiadis A.G. Erectile dysfunction. Annu Rev Med 54 (2003) 153-168
15. Jackson G. Erectile dysfunction: a marker of silent coronary artery disease. Eur Heart J 27 (2006) 2613-2614
16. Park J.K., Kim W., Kim S.W., et al. Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction. Int J Impot Res 11 (1999) 273-276
17. Erkan E., Muslumanoglu A.Y., Oktar T., et al. Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction. J Sex Med 3 (2006) 69-75 discussion 75-76
18. Peskircioglu L., Atac F.B., Erdem S.R., et al. The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction. Int J Impot Res 19 (2007) 149-153
19. Rosas-Vargas H., Coral-Vazquez R.M., Tapia R., et al. Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population. J Androl 25 (2004) 728-732
20. Eisenhardt A., Sperling H., Hauck E., et al. ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology 62 (2003) 152-157
21. Lee Y.C., Huang C.H., Wang C.J., et al. The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int 100 (2007) 1116-1120
22. Tangurek B., Ozer N., Sayar N., et al. The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in the Turkish population. Heart Vessels 21 (2006) 285-290
23. Ezzidi I., Mtiraoui N., Mohamed M.B., et al. Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T> C gene variants with diabetic nephropathy. J Diabetes Complications 22 (2008) 331-338
24. Casas J.P., Cavalleri G.L., Bautista L.E., et al. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol 164 (2006) 921-935
25. Dosenko V.E., Zagoriy V.Y., Haytovich N.V., et al. Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations. Acta Biochim Pol 53 (2006) 299-302
26. Rossi G.P., Taddei S., Virdis A., et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol 41 (2003) 938-945
27. Wattanapitayakul S.K., Mihm M.J., Young A.P., et al. Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci 22 (2001) 361-368
28. Laumann E.O., Paik A., and Rosen R.C. Sexual dysfunction in the United States: prevalence and predictors. J Am Med Assoc 281 (1999) 537-544
29. McKinlay J.B. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res 12 suppl 4 (2000) S6-S11
30. Jungersten L., Edlund A., Petersson A.S., et al. Plasma nitrate as an index of nitric oxide formation in man: analyses of kinetics and confounding factors. Clin Physiol 16 (1996) 369-379