Prolonged unconjugated hyperbilirubinaemia associated with the haem oxygenase-1 gene promoter polymorphism

Acta Paediatrica, International Journal of Paediatrics

Volumn 99, Issue 5, 2010, Pages 679-683

  Bozkaya, O G ^a   Kumral, A ^a   Yesilirmak, D C ^a   Ulgenalp, A ^a   Duman, N ^a   Ercal, D ^a   Ozkan, H ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

HO 1 gene promoter polymorphism; Newborn; Prolonged unconjugated hyperbilirubinaemia

Indexed keywords

BILIRUBIN; GENOMIC DNA; GLYCINE; HEME OXYGENASE 1; THREONINE;

ALLELE; ARTICLE; BILIRUBIN BLOOD LEVEL; BREAST MILK; CLINICAL ARTICLE; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DNA EXTRACTION; DNA FLANKING REGION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; NEWBORN; NEWBORN JAUNDICE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION;

ALLELES; BILIRUBIN; BREAST FEEDING; DNA; GENOME; GENOTYPE; HEME OXYGENASE-1; HUMANS; HYPERBILIRUBINEMIA, NEONATAL; INFANT, NEWBORN; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES;

EID: 77950294848     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2009.01678.x     Document Type: Article

References (30)

1. Newman TB, Easterling MJ, Goldman ES, Stevenson DK. Laboratory evaluation of jaundice in newborns. Frequency, cost, and yield. Am J Dis Child 1990 144 : 364 368.
2. Hall RT, Braun WJ, Callenbach JC, Metzl K, Sheehan MB, Kurth CG, et al. Hyperbilirubinemia in breast-versus formula-fed infants in the first six weeks of life: relationship to weight gain. Am J Perinatol 1983 1 : 47 51.
3. Stiehm Er, Ryan J. Breast-Milk Jaundice. Report of eight cases and effect of breast feeding on incidence and severity of unexplained hyperbilirubinemia. Am J Dis Child 1965 109 : 212 216.
4. Gourley GR. Pathophysiology of breast- milk jaundice. In : Polin RA, Fox WW, editors. Fetal and neonatal physiology. 2nd ed. Philadelphia : W.B. Saunders Company, 1998 137 : 1499.
5. Kumral A, Ozkan H, Duman N, Yesilirmak DC, Islekel H, Ozalp Y. Breast milk jaundice correlates with high levels of epidermal growth factor. Pediatr Res 2009 66 : 218 221.
6. Watchko JF. Genetics and the risk of neonatal hyperbilirubinemia: commentary on the article by Huang et al. on page 682. Pediatr Res 2004 56 : 677 678.
7. Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS. Risk factors for severe hyperbilirubinemia in neonates. Pediatr Res 2004 56 : 682 689.
8. Cui Y, König J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 2001 276 : 9626 9630.
9. Maruo Y, Nishizawa K, Sato H, Doida Y, Shimada M. Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism. Pediatrics 1999 103 : 1224 1227.
10. Elbirt KK, Bonkovsky HL. Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Physicians 1999 111 : 438 447.
11. Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004 15 : 37.
12. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000 66 : 187 195.
13. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004 114 : 297 316.
14. Kikuchi A, Yamaya M, Suzuki S, Yasuda H, Kubo H, Nakayama K, et al. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum Genet 2005 116 : 354 360.
15. Osborn LM, Reiff MI, Bolus R. Jaundice in the full-term neonate. Pediatrics 1984 73 : 520 525.
16. Schneider AP. Breast milk jaundice in the newborn. A real entity. JAMA 1986 255 : 3270 3274.
17. Maisels MJ, Gifford K. Normal serum bilirubin levels in the newborn and the effect of breast-feeding. Pediatrics 1986 78 : 837 843.
18. Kanai M, Akaba K, Sasaki A, Sato M, Harano T, Shibahara S, et al. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Pediatr Res 2003 54 : 165 171.
19. Ulgenalp A, Duman N, Schaefer FV, Whetsell L, Bora E, Gülcan H, et al. Analyses of polymorphism for UGT1*1 exon 1 promoter in neonates with pathologic and prolonged jaundice. Biol Neonate 2003 83 : 258 262.
20. Watchko JF, Daood MJ, Biniwale M. Understanding neonatal hyperbilirubinaemia in the era of genomics. Semin Neonatol 2002 7 : 143 152.
21. Gartner LM. Neonatal jaundice. Pediatr Rev 1994 15 : 422 432.
22. Huang CS. Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese. J Biomed Sci 2005 12 : 445 450.
23. Stevenson DK, Vreman HJ, Oh W, Fanaroff AA, Wright LL, Lemons JA, et al. Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Clin Chem 1994 40 : 1934 1939.
24. Exner M, Schillinger M, Minar E, Mlekusch W, Schlerka G, Haumer M, et al. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. J Endovasc Ther 2001 8 : 433 440.
25. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, et al. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 2002 111 : 1 8.
26. Schillinger M, Exner M, Mlekusch W, Domanovits H, Huber K, Mannhalter C, et al. Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm. Thromb Res 2002 106 : 131 136.
27. Ishibahara S, Nakayama M, Kitamuro T, Udono-Fujimori R, Takahashi K. Repression of heme oxygenase-1 expression as a defense strategy in humans. Exp Biol Med 2003 228 : 472 473.
28. Choi AM, Alam J. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996 15 : 9 19.
29. Bracci R, Buonocore G, Talluri B, Berni S. Neonatal hyperbilirubinemia. Evidence for a role of the erythrocyte enzyme activities involved in the detoxification of oxygen radicals. Acta Paediatr Scand 1988 77 : 349 356.
30. Baranano DE, Rao M, Ferris CD, Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci USA 2002 99 : 16093 16098.