Intralesional administration of allogeneic bone marrow stromal cells reduces functional deficits after intracerebral hemorrhage

Histology and Histopathology

Volumn 25, Issue 4, 2010, Pages 453-461

  Otero, L ^a   Bonilla, C ^a   Aguayo, C ^a   Zurita, M ^a   Vaquero, J ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Bone marrow stromal cells; Cell therapy; Endogenous neurogenesis; Intracerebral hemorrhage

Indexed keywords

ALLOTRANSPLANTATION; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN HEMORRHAGE; BRAIN INJURY; CONVALESCENCE; CYTOLOGY; DISEASE MODEL; FEMALE; INJURY SCALE; INTRALESIONAL DRUG ADMINISTRATION; METHODOLOGY; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; STROMA CELL; TRANSPLANTATION; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN INJURIES; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; FEMALE; INJECTIONS, INTRALESIONAL; INJURY SEVERITY SCORE; MOTOR ACTIVITY; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; STROMAL CELLS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 77950293557     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Andres R.H., Guzman R., Ducray A.D., Mordasini P., Gera A., Barth A., Widmer H.R. and Steinberg G.K. (2008). Cell replacement therapy for intracerebral hemorrhage. Neurosurg. Focus 24, E15.
2. Borlongan C.V., Hadma M., Sanberg C.D. and Sanberg P.R. (2004). Central nervouus system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35, 2385-2389.
3. Brown J.P., Couillard-Despres S., Cooper-Kuhn C.M., Winkler J., Aigner L. and Kunh H.G. (2003). Transient expression of doublecortin during adult neurogenesis. J. Comp. Neurol. 467, 1-10.
4. Ferro J.M. (2006). Update on intracerebral haemorrhage. J. Neurol. 253, 985-999.
5. Le Blanc K. and Ringdén O. (2005). Immunobiology of human mesenchymal stem cells and future use in hematopioetic stem cell transplantation. Biol. Blood Marrow. Transplant. 11, 321-334.
6. Lendahl U., Zimmerman L.B. and McKay R.D.G. (1990). CNS stem cells express a new class of intermediate filament protein. Cell 60, 585-595.
7. Li Y., Chen J. and Chopp M. (2001). Adult bone marrow transplantation after stroke in adult rats. Cell Transplant.10, 31-40.
8. Masuda T., Isobe Y., Aihara N., Furuyama F., Misumi S., Kim T., Nishino H. and Hida H. (2007). Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats. Neurosci. Lett. 425, 114-119.
9. Nan Z., Grande A., Sanberg C.D., Sanberg P.R. and Low W.C. (2005). Infusion of human umbilcal cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ann. N.Y. Acad. Sci. 1049, 84-96.
10. Rice A.C., Khaldi A., Harvey H.B., Salman N.J., White F., Fillmore H. and Bullock M.R. (2003). Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury. Exp. Neurol. 183, 406-417.
11. Richardson R.M., Sun D. and Bullock M.R. (2007). Neurogenesis after traumatic brain injury. Neurosurg. Clin. N. Am. 18, 169-181.
12. Romanko M.J., Rola R., Fike J.R., Szele F.G., Dizon M.L., Felling R.J., Brazel C.Y. and Levison S.W. (2004). Roles of the mammalian subventricular zone in cell replacement after brain injury. Progr. Neurobiol. 74, 77-99.
13. Salman H., Gosh P. and Kernie S.G. (2004). Subventricular zone neural stem cells remodel the brain following traumatic injury in adult mice. J. Neurotrauma 21, 283-292.
14. Seung-Wan Y., Sung-Soo K., Soo-Yeol L., Hey-Sun L., Hyung-Soo K., Young-Don L. and Suh-Kim H. (2008). Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model. Exp. Mol. Med. 40, 387-397
15. Seyfried D., Ding J., Han Y., Li Y., Chen J. and Chopp M. (2006). Effects of intravenous administration of human bone marrow stromal cells after cerebral hemorrhage in rats. J. Neurosurg. 104, 313-318.
16. Shen L.H., Li Y., Chen J., Cui Y., Zhang C., Kapke A., Lu M., Savant-Bhonsale S. and Chopp M. (2007). One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke 38, 2150-2156.
17. Tang T., Li X.Q., Wu H., Luo J.K., Zhang H.X. and Luo T.L. (2004). Activation of endogenous neural stem cells in experimental intracerebral hemorrhagic rat brains. Chin. Med. J. (Engl) 117, 1342-1347.
18. Urrea C., Castellanos D.A., Sagen J., Tsoulfas P., Bramlett H.M. and Dietrich W.D. (2007). Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor. Neurol. Neurosc. 25, 65-76.
19. Vaquero J. and Zurita M. (2009). Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol. Histopathol. 24, 107-116.
20. Vaquero J., Zurita M., Oya S. and Santos M. (2006). Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration? Neurosci. Lett. 398, 129-134.
21. Zhang H., Huang Z., Xu Y. and Zhang S. (2006). Differentiation and neurological benefit of the mesenchymal stem cells transplanted into the rat brain following intracerebral hemorrhage. Neurol. Res. 28, 104-112.
22. Zurita M. and Vaquero J. (2004). Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. Neuroreport. 15, 1105-1108.
23. Zurita M. and Vaquero J. (2006). Bone marrow stromal cells can achieve cure of chronic paraplegic rats: functional and morphological outcome one year after transplantation. Neurosci. Lett. 402, 51-56.
24. Zurita M., Vaquero J., Bonilla C., Santos M., De Haro J., Oya S. and Aguayo C. (2008). Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells. Transplantation 86, 845-853.