Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 298, Issue 4, 2010, Pages

  Vegesna, Anil K ^a   Braverman, Alan S ^a   Miller, Larry S ^a   Tallarida, Ronald J ^a   Tiwana, Mansoor I ^a   Khayyam, Umar ^a   Ruggieri Sr , Michael R ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal models; Gastroesophageal reflux; Receptor immunoprecipitation; Smooth muscle contractility

Indexed keywords

DARIFENACIN; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LOWER ESOPHAGUS SPHINCTER; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SWINE;

ANIMALS; BENZOFURANS; CARBACHOL; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGOGASTRIC JUNCTION; HUMANS; ISOMETRIC CONTRACTION; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PYRROLIDINES; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; SUS SCROFA;

EID: 77950276952     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00129.2009     Document Type: Article

References (23)

1. Aggestrup S, Uddman R, Jensen SL, Hakanson R, Sundler F, Schaffalitzky de Muckadell O, Emson P. Regulatory peptides in lower esophageal sphincter of pig and man. Dig Dis Sci 31: 1370-1375, 1986.
2. Brasseur JG, Ulerich R, Dai Q, Patel DK, Soliman AMS, Miller LS. Pharmacological dissection of the human gastro-oesophageal segment into three sphincteric components. J Physiol 580: 961-975, 2007.
3. Braverman AS, Lebed B, Linder M, Ruggieri MR. M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors. Neurourol Urodyn 26: 63-70, 2007.
4. 3 muscarinic receptor mediated contractions of human gastroesophageal smooth muscle. J Pharmacol Exp Ther 329: 218-224, 2009.
5. 3 muscarinic receptor subtype-induced mouse stomach contractions. J Pharmacol Exp Ther 325: 954-960, 2008.
6. Brown DR, Timmermans JP. Lessons from the porcine enteric nervous system. Neurogastroenterol Motil 16, Suppl 1: 50-54, 2004.
7. Burleigh DE. The effects of drugs and electrical field stimulation on the human lower oesophageal sphincter. Arch Int Pharmacodyn Ther 240: 169-176, 1979.
8. Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, Sonnenberg A, Stanghellini V, Stewart WF, Tack J, Talley NJ, Whitehead W, Revicki DA, Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, Sonnenberg A, Stanghellini V, Stewart WF, Tack J, Talley NJ, Whitehead W, Revicki DA. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol 3: 543-552, 2005.
9. Carsi JM, Valentine HH, Potter LT. m2-Toxin: a selective ligand for M2 muscarinic receptors. Mol Pharmacol 56: 933-937, 1999.
10. Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 58: 319-379, 1993.
11. Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50: 279-290, 1998.
12. Code CF, Fyke FE Jr, Schlegel JF. The gastroesophageal sphincter in healthy human beings. Gastroenterologia 86: 135-150, 1956.
13. Evans T, Hepler JR, Masters SB, Brown JH, Harden TK. Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. Biochem J 232: 751-757, 1985.
14. Gaddum J. The Quantitative effects of antagonistic drugs. J Physiol 89: 7P-9P, 1937.
15. Korn O, Stein HJ, Richter TH, Liebermann-Meffert D. Gastroesophageal sphincter: a model. Dis Esophagus 10: 105-109, 1997.
16. Lerche W. The Esophagus and Pharynx in Action. A Study of Structure in Relation to Function. Springfield, IL: Charles C. Thomas, 1950.
17. Liebermann-Meffert D, Allgower M, Schmid P, Blum AL. Muscular equivalent of the lower esophageal sphincter. Gastroenterology 76: 31-38, 1979.
18. McCray WH Jr, Chung C, Parkman HP, Miller LS. Use of simultaneous high-resolution endoluminal sonography (HRES) and manometry to characterize high pressure zone of distal esophagus. Dig Dis Sci 45: 1660-1666, 2000.
19. McKinney M, Miller JH, Gibson VA, Nickelson L, Aksoy S. Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition. Mol Pharmacol 40: 1014-1022, 1991.
20. Miller LS, Dai Q, Vegesna A, Korimilli A, Ulerich R, Schiffner B, Brasseur JG. A missing sphincteric component of the gastro-esophageal junction in patients with GERD. Neurogastroenterol Motil 21: 813-e52, 2009.
21. Schopf BW, Blair G, Dong S, Troger K. A porcine model of gastroesophageal reflux. J Invest Surg 10: 105-114, 1997.
22. Tian ZQ, Liu JF, Wang GY, Li BQ, Wang FS, Wang QZ, Cao FM, Zhang YF. Responses of human clasp and sling fibers to neuromimetics. J Gastroenterol Hepatol 19: 440-447, 2004.
23. Vicente Y, Da Rocha C, Yu J, Hernandez-Peredo G, Martinez L, Perez-Mies B, Tovar JA. Architecture and function of the gastroesophageal barrier in the piglet. Dig Dis Sci 46: 1899-1908, 2001.