Induced sputum nitrites correlate with FEV1 in children with cystic fibrosis

Acta Paediatrica, International Journal of Paediatrics

Volumn 99, Issue 5, 2010, Pages 711-714

  Anil, N ^a   Singh, M ^a   Rajwanshi, A ^a   Vohra, H ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Cystic fibrosis; Induced sputum; Lung function; Nitrites

Indexed keywords

BIOLOGICAL MARKER; NITRIC OXIDE; NITRITE;

ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LEUKOCYTE DIFFERENTIAL COUNT; LUNG FUNCTION; MALE; NEUTROPHIL COUNT; NON INVASIVE MEASUREMENT; PATIENT ASSESSMENT; PATIENT MONITORING; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SCHOOL CHILD; SPIROMETRY; SPUTUM LEVEL;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CYSTIC FIBROSIS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; MALE; NEUTROPHILS; NITRITES; SPIROMETRY; SPUTUM; VITAL CAPACITY;

EID: 77950268749     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2010.01682.x     Document Type: Article

References (29)

1. Davis PB, Drumm M, Konstan MW. Cystic fibrosis. Am J Respir Crit Care Med 1996 154 : 1229 1256.
2. Seibert FS, Tabcharan JA, Chang XB. cAMP-dependent protein kinase mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue and its role in channel activation. J Biol Chem 1995 270 : 2158 2162.
3. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DWH. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995 151 : 1075 1082.
4. Ricciardolo FLM. Multiple roles of nitric oxide in the airways. Thorax 2003 58 : 175 182.
5. Moncada S. NO: mediator, modulator, and pathophysiologic entity. J Lab Clin Med 1992 120 : 187 191.
6. Head CA. Nitric oxide and the lung: an overview. Artif Organs 1997 27 : 5 9.
7. Ratjen F, Gartig S, Weisemann HG, Grasemann H. Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis. Respir Med 1999 93 : 579 583.
8. Barnes PJ, Belvisi MG. Nitric oxide and lung disease. Thorax 1993 48 : 1034 1043.
9. Grasemann H, Ratjen F. Cystic fibrosis lung disease: the role of nitric oxide. Pediatr Pulmonol 1999 28 : 442 448.
10. Khartionov SA, Wells AW, O'Connor BJ. Elevated levels of exhaled nitric oxide in bronchectasis. Am J Respir Crit Care Med 1995 151 : 1889 1893.
11. Lundberg JON, Nordvall SL, Weitzberg E, Alving K. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child 1996 75 : 323 326.
12. Ho LP, Innes JA, Greening AP. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax 1998 53 : 680 684.
13. Grasemann H, Ioannidis I, Tomkiewicz RP, deGroot H, Rubin BK, Ratjen F. Nitric oxide metabolites in cystic fibrosis lung disease. Arch Dis Child 1998 78 : 49 53.
14. Balfour-Lynn IM, Laverty A, Dinwinddie R. Reduced upper airway nitric oxide in cystic fibrosis. Arch Dis Child 1996 75 : 319 322.
15. Ho LP, Innes JA, Greening AP. Exhaled nitric oxide is not elevated in inflammatory airway disease of cystic fibrosis and bronchiectasis. Eur Respir J 1998 12 : 1290 1294.
16. Grasemann H, Michler E, Wallot M, Ratjen F. Decreased concentration of exhaled nitric oxide in patients with cystic fibrosis. Pediatr Pulmonol 1997 24 : 173 177.
17. Linnane SJ, Keatings VM, Costello CM, Moynihan JB, O'Connor CN, Fitzgerald MX, et al. Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis. Am J Respir Crit Care Med 1998 158 : 207 212.
18. Sagel SD, Sontag MK, Wagener JS, Kapsner RK, Osberg I, Accurso FJ. Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis. J Pediatr 2002 141 : 811 817.
19. Mayer-Hamblett N, Aitken ML, Accurso FJ, Kronmal RA, Konstan MW, Burns JL, et al. Association between pulmonary function and sputum biomarkers in cystic fibrosis. Am J Respir Crit Care Med 2007 175 : 822 828.
20. Sagel SD, Kapsner R, Osberg I, Sontag MK, Accurso FJ. Airway inflammation in children with Cystic fibrosis and healthy children assessed by sputum induction. Am J Respir Crit Care Med 2001 164 : 1425 1431.
21. Phizacheerley P. The estimation of nitrate and nitrite in sputum and urine. Ann Biochem 1983 131 : 242 245.
22. Shwachman H, Kulczycki LL. Long term study of 105 patients with CF. Am J Dis Child 1958 96 : 6 15.
23. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardization of spirometry. Eur Respir J 2005 26 : 319 338.
24. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B. Changes in the normal maximal expiratory flow volume curve with growth and aging. Am Rev Resp Dis 1983 127 : 725 734.
25. Grasemann H, Ioannidis I, de Groot H, Ratjen F. Metabolites of nitric oxide in the lower respiratory tract of children. Eur J Pediatr 1997 156 : 575 578.
26. Grasemann H, Gaston B, Fang K, Paul K, Ratjen F. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal lung function. J Pediatr 1999 135 : 770 772.
27. Francoeur C, Denis M. Nitric oxide and interlurkin-8 as inflammatory components of cystic fibrosis. Inflammation 1995 19 : 587 598.
28. Jones KL, Bryan TW, Jinkins PA, Simpson KL, Grisham MB, Ovens MW, et al. Superoxide released from neutrophils causes a reduction in nitric oxide gas. Am J Physiol 1998 275 : L1120 6.
29. Jobsis Q, Raatgeep HC, Schellekens SL, Kroesbergen A, Hop WCJ, de Jongste JC. Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur Respir J 2000 16 : 95 100.