A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers

Cancer Research

Volumn 70, Issue 6, 2010, Pages 2359-2367

  Amos, Christopher I ^a   Pinney, Susan M ^b   Li, Yafang ^a   Kupert, Elena ^b   Lee, Juwon ^b   De Andrade, Mariza A ^c   Yang, Ping ^c   Schwartz, Ann G ^d   Fain, Pam R ^e   Gazdar, Adi ^f   Minna, John ^f   Wiest, Jonathan S ^g   Zeng, Dong ^a   Rothschild, Henry ^h   Mandal, Diptasri ^h   You, Ming ⁱ   Coons, Teresa ^j   Gaba, Colette ^k   Bailey Wilson, Joan E ^l   Anderson, Marshall W ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c Mayo Clinic   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g NATIONAL CANCER INSTITUTE   (United States)

^h LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

ⁱ WASHINGTON UNIVERSITY   (United States)

^j Saccomanno Research Institute   (United States)

^k MEDICAL COLLEGE OF OHIO   (United States)

^l NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME 6Q; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC RISK; HAPLOTYPE; HETEROZYGOTE; HUMAN; LINKAGE ANALYSIS; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SMOKING HABIT;

CHROMOSOMES, HUMAN, PAIR 6; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE (GENETICS); LUNG NEOPLASMS; MALE; SMOKING;

EID: 77950241825     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3096     Document Type: Article

References (31)

1. Tokuhata GK, Lilienfeld AM. Familial aggregation of lung cancer in humans. J Natl Cancer Inst 1963;30:289-312.
2. Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE, Rothschild H. Increased familial risk for lung cancer. J Natl Cancer Inst 1986;76:217-222
3. Shaw GL, Falk RT, Pickle LW, Mason TJ, Buffler PA. Lung cancer risk associated with cancer in relatives. J Clin Epidemiol 1991;44:429-437
4. Etzel CJ, Amos CI, Spitz MR. Risk for smoking-related cancer among relatives of lung cancer patients. Cancer Res 2003;63:8531-8535
5. Jonsson S, Thorsteinsdottir U, Gudbjartsson DF, et al. Familial risk of lung carcinoma in the Icelandic population. JAMA 2004;292:2977-2983
6. Sellers TA, Bailey-Wilson JE, Elston RC, et al. Evidence for mendelian inheritance in the pathogenesis of lung cancer. J Natl Cancer Inst 1990;82:1272-1279
7. Gauderman WJ, Morrison JL, Carpenter CL, Thomas DC. Analysis of gene-smoking interaction in lung cancer. Genet Epidemiol 1997;14:199-214.
8. Bailey-Wilson JE, Amos CI, Pinney SM, et al. A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet 2004;75:460-474
9. Ott J. Analysis of human genetic linkage. Baltimore (MD): Johns Hopkins University Press; 1999.
10. Goring HH, Ott J. Relationship estimation in affected sib pair analysis of late-onset diseases. Eur J Hum Genet 1997;5:69-77.
11. McPeek MS, Sun L. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 2000;66:1076-1094
12. SIB-PAIR [computer program]. Brisbane: Queensland Institute for Medical Research; 2009.
13. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259-266
14. Boehnke M. Allele frequency estimation from data on relatives. Am J Hum Genet 1991;48:22-25
15. Cottingham RW, Jr., Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993;53:252-263
16. Speer MC. Use of LINKAGE programs for linkage analysis. Curr Protoc Hum Genet 2006;Chapter 1:Unit 1.7.
17. Elston RC, Sobel E. Sampling considerations in the gathering and analysis of pedigree data. Am J Hum Genet 1979;31:62-69
18. Ott J. Complex traits on the map. Nature 1996;379:772-773
19. Antoniou AC, Goldgar DE, Andrieu N, et al. A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol 2005;29:1-11.
20. Schoenborn CA, Adams PF, Schiller JS. Summary health statistics for the U.S. population: National Health Interview Survey, 2000. Vital Health Stat 2003;10:1-83.
21. Woo JG, Pinney SM. Retrospective smoking history data collection for deceased workers: completeness and accuracy of surrogate reports. J Occup Environ Med 2002;44:915-923
22. Hansen KS. Validity of occupational exposure and smoking data obtained from surviving spouses and colleagues. Am J Ind Med 1996;30:392-397
23. Lerchen ML, Samet JM. An assessment of the validity of questionnaire responses provided by a surviving spouse. Am J Epidemiol 1986;123:481-489
24. McLaughlin N. Smoking bans, restrictions increase at country's healthcare facilities. Mod Healthc 1987;17:92.
25. Hyland A, Cummings KM, Lynn WR, Corle D, Giffen CA. Effect of proxy-reported smoking status on population estimates of smoking prevalence. Am J Epidemiol 1997;145:746-751
26. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest 2003;123:21S-49S.
27. Below JE, Pluznikov A, Aquino-Michaels K, et al. Localization of a dominant genetic susceptibility factor in familial malignant mesothelioma. Presented at the annual meeting of The American Society of Human Genetics; 2008 Nov 12; Philadelphia, Pennsylvania. http://www.ashg.org/2008meeting/abstracts/ fulltext.
28. You M, Wang D, Liu P, et al. Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res 2009;15:2666-2674
29. Paine RS. The variability in manifestations of untreated patients with phenylketonuria (phenylpyruvic aciduria). Pediatrics 1957;20:290-302.
30. Tschudy DP, Valsamis M, Magnussen CR. Acute intermittent porphyria: clinical and selected research aspects. Ann Intern Med 1975;83:851-864
31. Jones S, Hruban RH, Kamiyama M, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009;324:217.