Genetic predictors of acute renal transplant rejection

Nephrology Dialysis Transplantation

Volumn 25, Issue 4, 2010, Pages 1039-1047

  Goldfarb Rumyantzev, Alexander S ^a   Naiman, Natalie ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; COMPLEMENT COMPONENT C3; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FAS ANTIGEN; FC RECEPTOR IIA; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; TACROLIMUS; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ACUTE GRAFT REJECTION; AFRICAN AMERICAN; ASIAN; CYTOKINE PRODUCTION; DISEASE COURSE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT REJECTION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE DISEASE; GENETIC MARKERS; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; POLYMORPHISM, GENETIC; SURVIVAL RATE;

EID: 77950238321     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp782     Document Type: Review

References (76)

1. Almond PS, Matas A, Gillingham K, et al. Risk factors for chronic rejection in renal allograft recipients. Transplantation 1993; 55: 752-756; discussion 756-757
2. Kamoun M. Cellular and molecular parameters in human renal allo-graft rejection. Clin Biochem 2001; 34: 29-34
3. Massy ZA, Guijarro C, Wiederkehr MR, et al. Chronic renal allograft rejection: immunologic and nonimmunologic risk factors. Kidney Int 1996; 49: 518-524
4. Matas AJ, Gillingham KJ, Payne WD, et al. The impact of an acute rejection episode on long-term renal allograft survival (t1/2). Transplantation 1994; 57: 857-859
5. Ramanathan V, Goral S, Helderman JH. Renal transplantation. Semin Nephrol 2001; 21: 213-219
6. Shoskes DA, Cecka JM. Deleterious effects of delayed graft function in cadaveric renal transplant recipients independent of acute rejection. Transplantation 1998; 66: 1697-1701
7. Mahalati K, Belitsky P, Sketris I, et al. Neoral monitoring by simplified sparse sampling area under the concentration-time curve: its relationship to acute rejection and cyclosporine nephro-toxicity early after kidney transplantation. Transplantation 1999; 68: 55-62
8. Nickerson P, Jeffery J, Gough J, et al. Effect of increasing baseline immunosuppression on the prevalence of clinical and subclinical rejection: a pilot study. J Am Soc Nephrol 1999; 10: 1801-1805
9. van Saase JL, van der Woude FJ, Thorogood J, et al. The relation between acute vascular and interstitial renal allograft rejection and subsequent chronic rejection. Transplantation 1995; 59: 1280-1285
10. Flechner SM, Kurian SM, Head SR, et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4: 1475-1489
11. Sarwal M, Chua MS, Kambham N, et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-138
12. Goldfarb-Rumyantzev AS, Shihab F, Emerson L, et al. A population-based assessment of the familial component of acute kidney allograft rejection. Nephrol Dial Transplant 2009; 24: 2575-2583
13. Dallman MJ. Cytokines as mediators of organ graft rejection and tolerance. Curr Opin Immunol 1993; 5: 788-793
14. Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002; 8: 582-587
15. Andrews PA, Finn JE, Mathieson PW, et al. Molecular analysis of C3 allotypes related to transplant outcome in human renal allografts. Transplantation 1995; 60: 1342-1346
16. Brown KM, Kondeatis E, Vaughan RW, et al. Influence of donor C3 allotype on late renal-transplantation outcome. N Engl J Med 2006; 354: 2014-2023
17. Soulillou JP, Giral M. Influence of graft characteristics on the outcome of kidney transplantation. N Engl J Med 2006; 354: 2060-2062
18. Varagunam M, Yaqoob MM, Dohler B, et al. C3 polymorphisms and allograft outcome in renal transplantation. N Engl J Med 2009; 360: 874-880
19. Pascher A, Klupp J. Biologics in the treatment of transplant rejection and ischemia/reperfusion injury: new applications for TNFalpha inhibitors? BioDrugs 2005; 19: 211-231
20. Hahn AB, Kasten-Jolly JC, Constantino DM, et al. TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: effects on renal allograft outcome. Transplantation 2001; 72: 660-665
21. Sankaran D, Asderakis A, Ashraf S, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. Kidney Int 1999; 56: 281-288
22. Louis E, Franchimont D, Piron A, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysac-charide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998; 113: 401-406
23. Elahi MM, Asotra K, Matata BM, et al. Tumor necrosis factor alpha-308 gene locus promoter polymorphism: an analysis of association with health and disease. Biochim Biophys Acta 2009; 1792: 163-172
24. Pelletier R, Pravica V, Perrey C, et al. Evidence for a genetic predisposition towards acute rejection after kidney and simultaneous kidney-pancreas transplantation. Transplantation 2000; 70: 674-680
25. Grinyo J, Vanrenterghem Y, Nashan B, et al. Association of four DNA polymorphisms with acute rejection after kidney transplantation. Transpl Int 2008; 21: 879-891
26. Manchanda PK, Mittal RD. Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation. Mol Cell Biochem 2008; 311: 57-65
27. Poli F, Boschiero L, Giannoni F, et al. Tumour necrosis factor-alpha gene polymorphism: implications in kidney transplantation. Cytokine 2000; 12: 1778-1783
28. Tinckam K, Rush D, Hutchinson I, et al. The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology. Transplantation 2005; 79: 836-841
29. Alakulppi NS, Kyllonen LE, Jantti VT, et al. Cytokine gene polymorphisms and risks of acute rejection and delayed graft function after kidney transplantation. Transplantation 2004; 78: 1422-1428
30. Lee H, Clark B, Gooi HC, et al. Influence of recipient and donor IL-1alpha, IL-4, and TNFalpha genotypes on the incidence of acute renal allograft rejection. J Clin Pathol 2004; 57: 101-103
31. Dmitrienko S, Hoar DI, Balshaw R, et al. Immune response gene polymorphisms in renal transplant recipients. Transplantation 2005; 80: 1773-1782
32. Marshall SE, McLaren AJ, Haldar NA, et al. The impact of recipient cytokine genotype on acute rejection after renal transplantation. Transplantation 2000; 70: 1485-1491
33. Wramner LG, Norrby J, Hahn-Zoric M, et al. Impaired kidney graft survival is associated with the TNF-alpha genotype. Transplantation 2004; 78: 117-121
34. Brabcova I, Petrasek J, Hribova P, et al. Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation. Transplantation 2007; 84: 1037-1044
35. Loucaidou M, Stitchbury J, Lee J, et al. Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression. Transplant Proc 2005; 37: 1760-1761
36. McDaniel DO, Barber WH, Nguyan C, et al. Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients. Transpl Immunol 2003; 11: 107-119
37. Kimball P, Reid F. Tumor necrosis factor beta gene polymorphisms associated with urinary tract infections after renal transplantation. Transplantation 2002; 73: 1110-1112
38. Cappellesso S, Valentin JF, Giraudeau B, et al. Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control study. Nephrol Dial Transplant 2004; 19: 439-443
39. Grinyo J, Vanrenterghem Y, Nashan B, et al. Association of four DNA polymorphisms with acute rejection after kidney transplantation. Transpl Int 2008; 21: 879-891
40. Asderakis A, Sankaran D, Dyer P, et al. Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: the cytokine effect on transplantation. Transplantation 2001; 71: 674-677
41. Azarpira N, Aghdaie MH, Geramizadeh B, et al. Cytokine gene polymorphisms in renal transplant recipients. Exp Clin Transplant 2006; 4: 528-531
42. Bamoulid J, Courivaud C, Deschamps M, et al. IL-6 promoter polymorphism-174 is associated with new-onset diabetes after transplantation. J Am Soc Nephrol 2006; 17: 2333-2340
43. Morgun A, Shulzhenko N, Rampim GF, et al. Interleukin-2 gene polymorphism is associated with renal but not cardiac transplant outcome. Transplant Proc 2003; 35: 1344-1345
44. Marshall SE, McLaren AJ, McKinney EF, et al. Donor cytokine genotype influences the development of acute rejection after renal transplantation. Transplantation 2001; 71: 469-476
45. Singh R, Kesarwani P, Ahirwar DK, et al. Interleukin 8-251T>A and interferon gamma +874A>T polymorphism: potential predictors of allograft outcome in renal transplant recipients from north India. Transpl Immunol 2009; 21: 13-17
46. Hoffmann TW, Halimi JM, Buchler M, et al. Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantation. Transplantation 2008; 85: 1406-1411
47. Kim CD, Ryu HM, Choi JY, et al. Association of G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients. Transplantation 2008; 86: 1610-1614
48. Schoenborn JR, Wilson CB. Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 2007; 96: 41-101
49. Azarpira N, Aghdai MH, Raisjalali GA, et al. Influence of recipient and donor IL-10, TNFA and INFG genotypes on the incidence of acute renal allograft rejection. Mol Biol Rep 2009; 36: 1621-1626
50. Shahbazi M, Fryer AA, Pravica V, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 2002; 13: 260-264
51. Kang SW, Park SJ, Kim YW, et al. Association of MCP-1 and CCR2 polymorphisms with the risk of late acute rejection after renal transplantation in Korean patients. Int J Immunogenet 2008; 35: 25-31
52. Salido E, Martin B, Barrios Y, et al. The PlA2 polymorphism of the platelet glycoprotein IIIA gene as a risk factor for acute renal allograft rejection. J Am Soc Nephrol 1999; 10: 2599-2605
53. Chow KM, Szeto CC, Szeto CY, et al. Plasminogen activator inhibi-tor-1 polymorphism is associated with progressive renal dysfunction after acute rejection in renal transplant recipients. Transplantation 2002; 74: 1791-1794
54. Abdi R, Tran TB, Sahagun-Ruiz A, et al. Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J Am Soc Nephrol 2002; 13: 754-758
55. Cha RH, Yang SH, Kim HS, et al. Genetic interactions between the donor and the recipient for susceptibility to acute rejection in kidney transplantation: polymorphisms of CCR5. Nephrol Dial Transplant 2009; 24: 2919-2925
56. Yuan FF, Watson N, Sullivan JS, et al. Association of Fc gamma receptor IIA polymorphisms with acute renal-allograft rejection. Transplantation 2004; 78: 766-769
57. Tajik N, Salari F, Ghods AJ, et al. Association between recipient ICAM-1 K469 allele and renal allograft acute rejection. Int J Immu-nogenet 2008; 35: 9-13
58. Slavcheva E, Albanis E, Jiao Q, et al. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. Transplantation 2001; 72: 935-940
59. Ducloux D, Deschamps M, Yannaraki M, et al. Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int 2005; 67: 2454-2461
60. Hwang YH, Ro H, Choi I, et al. Impact of polymorphisms of TLR4/CD14 and TLR3 on acute rejection in kidney transplantation. Transplantation 2009; 88: 699-705
61. Palmer SM, Burch LH, Mir S, et al. Donor polymorphisms in Tolllike receptor-4 influence the development of rejection after renal transplantation. Clin Transplant 2006; 20: 30-36
62. Zhang G, Wang H, Wang F, et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and angiotensin II type 1-receptor activating antibodies in renal rejection. Tohoku J Exp Med 2007; 213: 203-214
63. Krajewska M, Koscielska-Kasprzak K, Weyde W, et al. Impact of donor-dependent genetic factors on long-term renal graft function. Transplant Proc 2009; 41: 2978-2980
64. Hocher B, Slowinski T, Hauser I, et al. Association of factor V Leiden mutation with delayed graft function, acute rejection episodes and long-term graft dysfunction in kidney transplant recipients. Thromb Haemost 2002; 87: 194-198
65. Alakulppi NS, Kyllonen LE, Partanen J, et al. Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation. Nephrol Dial Transplant 2008; 23: 364-368
66. Muller V, Molnar Z, Szabo AJ. Single nucleotide polymorphism: is it only genetic palmistry? Transplantation 2007; 84: 954-955
67. Daly AK. Individualized drug therapy. Curr Opin Drug Discov Devel 2007; 10: 29-36
68. Nebert DW, Vesell ES. Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead. Eur J Pharmacol 2004; 500: 267-280
69. Benavides CA, Pollard VB, Mauiyyedi S, et al. BK virus-associated nephropathy in sirolimus-treated renal transplant patients: incidence, course, and clinical outcomes. Transplantation 2007; 84: 83-88
70. Bosmans JL, Verpooten GA. Malignancy after kidney transplantation: still a challenge. Kidney Int 2007; 71: 1197-1199
71. Maalouf NM, Shane E. Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 2005; 90: 2456-2465
72. Breiman L, Friedman JH, Olshen RA, et al. Classification and Regression Trees. Monterey, CA: Wadsworth and Brooks/Cole, 1984
73. Cross SS, Harrison RF, Kennedy L. Introduction to neural networks. Lancet 1995; 346: 1075-1079
74. Hastie T, Tibshirani R. Generalized additive models for medical research. Stat Methods Med Res 1995; 4: 187-196
75. Goldfarb-Rumyantzev AS, Scandling JD, Pappas L, et al. Prediction of 3-yr cadaveric graft survival based on pre-transplant variables in a large national dataset. Clin Transplant 2003; 17: 485-497
76. Krikov S, Khan A, Baird BC, et al. Predicting kidney transplant survival using tree-based modeling. ASAIO J 2007; 53: 592-600