Immunomodulatory effects of damnacanthal isolated from roots of Morinda elliptica

Pharmaceutical Biology

Volumn 48, Issue 4, 2010, Pages 446-452

  Alitheen, Noorjahan B ^a   Manaf, A Abdul ^a   Yeap, S K ^a   Shuhaimi, M ^a   Nordin, L ^a   Mashitoh, A R ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Damnacanthal; Immunomodulation; Interleukin 2; Morinda elliptica

Indexed keywords

DAMNACANTHAL; IMMUNOMODULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MALE; MITOGENESIS; MORINDA; MORINDA ELLIPTICA; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT ROOT; THYMOCYTE; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTHRAQUINONES; CELL PROLIFERATION; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-12; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALAYSIA; MALE; MICE; MICE, INBRED ICR; MORINDA; PLANT ROOTS; THYMUS GLAND; TIME FACTORS;

MORINDA ELLIPTICA; RUBIACEAE;

EID: 77950221958     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880200903168031     Document Type: Article

References (27)

1. Adam JK, Odhav B, Bhoola KD (2003): Immune responses in cancer. Pharmacol Ther 99: 113-132.
2. Ali AM, Ismail N, Mackeen M, Yazan L, Mohamed S, Ho A, Lajis N (2000): Antiviral, cytotoxic and antimicrobial activities of antharaquinones isolated from the roots of Morinda elliptica. Pharm Biol 38: 3791-3801.
3. 2+)] (i) elevation in human dermal fibroblasts. Eur J Pharm 387: 119-124.
4. Bryan DL, Forsyth KD, Gibson RA, Hawkes JS (2006): Interleukin-2 in human milk: A potential modulator of lymphocyte development in breastfed infant. Cytokine 33: 289-293.
5. Cerqueira F, Cordeiro-Da-Silva A, Gaspar-Marques C, Simoes F, Pinto MMM, Nascimento MSJ (2004): Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocytes proliferation. Bioorg Med Chem 12: 217-223.
6. Chandok MR, Farber DL (2004): Signalling control of memory T cell generation and function. Semin Immunol 16: 285-293.
7. Farag SS, Caliguiri MA (2006): Human natural killer cells development and biology. Blood Rev 20: 123-137.
8. Hiramatsu T, Imato M, Koyono T, Umezawa K (1993): Induction of normal phenotypes in Ras transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett 73: 161-166.
9. Hirazumi A, Furusawa E, Chou SC, Hokama Y (1994): Anti-cancer activity of Morinda citrifolia on intraperitoneally implanted Lewis lung carcinoma in syngenic mice. Proc West Pharmacol Soc 37: 145-146.
10. Hirazumi A, Furusawa E, Chou SC, Hokama Y (1996): Immunomodulation contributes to the anti-cancer activity of Morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 39: 7-9.
11. Hirazumi A, Furusawa E, Chou SC, Hokama Y (1999): Immunomodulatory polysaccharide-rich substances from the fruit juice of Morinda citrifolia (noni) with anti-tumor activity. Phytother Res 13: 380-387.
12. Hiwasa T, Arase Y, Chen Z, Kita K, Umezawa K, Ito H, Suzuki N (1999): Stimulation of ultraviolet-induced apoptosis of human fibroblast UV-1 cells by tyrosine kinase inhibitors. FEBS Lett 444: 173-176.
13. Ismail NH, Ali AM, Aimi N, Kitajima M, Takayama H, Lajis NH (1997): Anthraquinones from Morinda elliptica. Phytochemistry 45: 1723-1725.
14. Jasril K, Nordin HL, Lim YM, Abdullah MA, Sukari MA, Ali MA (2003): Antitumor promoting and antioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica. Asia Pac J Mol Biol Biotechnol 11: 3-7.
15. Kwanjai K, Somdej K, Ruchanee P (2005): Biological activity of anthraquinones and triterpenoids from Prismatomeris fragrans. J Ethnopharmacol 100: 184-288.
16. Li J, Li Q, Feng T, Li K (2008): Aqueous extract of Solanum nigrum inhibit growth of cervical carcinoma (U14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor cells. Fitoterapia 79: 548-556.
17. Loken MR (1980): Simultaneous quantitation of Hoechst 33342 and immunofluorescence on viable cells using a fluorescence activated cell sorter. Cytometry 1: 136-142.
18. Manosroi A, Saraphanchotiwitthaya A, Manosroi J (2003): Immunomodulatory activities of Clausena excavata Burm. f. wood extracts. J. Ethnopharmacol 89: 155-160.
19. Manuele MG, Ferraro G, Barreiro Arcos ML, López P, Cremaschi G, Anesini C (2006): Comparative immunomodulatory effect of scopoletin on tumoral and normal lymphocytes. Life Sci 79: 2043-2048.
20. Masakazu K, Raymond PW, Dong SA, Jonathan PS, Robert D, Micheal EP, Jing H, Irvin, SYC (2006): Cell-based chemical genetic screen identifies damnacanthal inhibitor of HIV-Vpr induced cell death. Biochem Biophys Res Comm 384: 1101-1106.
21. Mosmann T (1983): Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assay. J Immunol Methods 65: 55-63.
22. Ong HC, Norzalina J (1999): Malay herbal medicine in Gemencheh, Negeri Sembilan, Malaysia. Fitoterapia 70:10-14.
23. Stanilove SA, Dobreva ZG, Slavov ES, Mitera LD (2005): C3 binding glycoprotein from Cuscuta europea induced different cytokine profile from human PBMC compared to other plant and bacteria immunomodulators. Int Immunopharmacol 5: 727-734.
24. Tosa H, Ilnuma M, Asai F, Tanaka T, Nozaki H, Fujimori S (1998): Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II. Biol Pharm Bull 21: 641-642.
25. Wang MY, Su C (2001): Cancer preventive effect of Morinda citrifolia (noni). Ann NY Acad Sci 952: 161-168.
26. Wang MY, West B, Jensen CJ, Nowicki D, Su C, Palu AK, Anderson G (2002): Morinda citrifolia (noni): A literature review and recent advances in noni research. Acta Pharmacol Sin 23: 1127-1141.
27. Zhao M, Yang B, Wang J, Liu Y, Yu L, Jiang Y (2007): Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn.) pericarp. Int Immunopharmacol 7: 162-177.