Nonlinear mixed effects models applied to cumulative concentration-response curves

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 3, 2010, Pages 339-345

  Thorin, Chantal ^a   Mallem, Mohamed Yassine ^a   Noireaud, Jacques ^a   Gogny, Marc ^a   Desfontis, Jean Claude ^a  

^a UPSP 5304 Laboratoire de Physiopathologie animale et de Pharmacologie fonctionnelle   (France)

Author keywords

Cumulative concentration response curves; Heteroscedasticity; Nonlinear mixed effects model; Statistic

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; ISOPRENALINE; NADOLOL; PHENYLEPHRINE;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CUMULATIVE CONCENTRATION RESPONSE CURVE; INTERMETHOD COMPARISON; MALE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; RAT; STATISTICAL MODEL; THORACIC AORTA;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MODELS, STATISTICAL; NONLINEAR DYNAMICS; PHARMACOLOGY; PROTEIN ISOFORMS; RATS; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, BETA; STATISTICS AS TOPIC; VASODILATION;

EID: 77950211787     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.03.0008     Document Type: Article

References (12)

1. Bretz, F, et al. Combining multiple comparisons and modeling techniques in dose response studies. Biometrics 2005 61 : 738 748.
2. Hill, AV. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol (London) 1919 40 : iv vii.
3. Kenakin, T. Principles: receptor theory in pharmacology. Trends Pharmacol Sci 2004 25 : 186 192.
4. Davidian M, Giltinan DM. Nonlinear Models for Repeated Measurement Data. New York : Chapman & Hall-CRC, 1995.
5. De Mayer, JH, et al. Porcine left atrial and sinoatria1 5-HT4 receptor-induced responses: fading of the response and influence of development. Br J Pharmacol 2006 147 : 140 157.
6. Bidon, J-C, et al. Effect of guinea-pig purified immunoglobulin G1 on the responsiveness of tracheal, aortic, vas deferens and ileum smooth muscles. Clin Exp Allergy 1995 25 : 1246 1253.
7. Mallem, MY, et al. Evaluation of beta3-adrenoceptor-mediated relaxation in intact and endotoxin-treated equine digital veins. Am J Vet Res 2003 64 : 708 714.
8. Mallem, MY, et al. Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats. Br J Pharmacol 2004 143 : 599 605.
9. Mallem, MY, et al. Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats. Auton Neurosci 2005 118 : 61 67.
10. Pinheiro JC, Bates DM. Mixed-Effects Models in S and S-Plus. New York : Springer-Verlag, 2000.
11. Trochu, JN, et al. Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta. Br J Pharmacol 1999 128 : 69 76.
12. Huet S et al. Statistical Tools for Nonlinear Regression: a practical guide with S-PLUS and R examples, 2nd edn. New York : Springer-Verlag, 2004.