Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes

Leukemia Research

Volumn 34, Issue 5, 2010, Pages 615-621

  Santos, Joana ^a   Cerveira, Nuno ^a   Bizarro, Susana ^a   Ribeiro, Franclim R ^a   Correia, Cecília ^a   Torres, Lurdes ^a   Lisboa, Susana ^a   Vieira, Joana ^a   Mariz, José M ^a   Norton, Lucília ^a   Snijder, Simone ^b   Mellink, Clemens H ^b   Buijs, Arjan ^c   Shih, Lee Yung ^d   Strehl, Sabine ^e   Micci, Francesca ^f   Heim, Sverre ^f,g   Teixeira, Manuel R ^a,h  

^a PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF OSLO   (Norway)

^h UNIVERSITY OF PORTO   (Portugal)

Author keywords

Gene expression; Gene fusion; MLL; Myeloid neoplasia; Septin

Indexed keywords

MIXED LINEAGE LEUKEMIA PROTEIN; SEPTIN; SEPTIN 1; SEPTIN 10; SEPTIN 11; SEPTIN 12; SEPTIN 13; SEPTIN 2; SEPTIN 3; SEPTIN 4; SEPTIN 5; SEPTIN 6; SEPTIN 7; SEPTIN 8; SEPTIN 9; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; DOWN REGULATION; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE FUSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; KARYOTYPE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; CYTOSKELETAL PROTEINS; GENE EXPRESSION; GTP-BINDING PROTEINS; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; MIDDLE AGED; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 77950071392     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.08.018     Document Type: Article

References (38)

1. Hall P.A., Russell S.E. The pathobiology of the septin gene family. J Pathol 2004, 204:489-505.
2. Hall P.A., Jung K., Hillan K.J., Russell S.E. Expression profiling the human septin gene family. J Pathol 2005, 206:269-278.
3. Peterson E.A., Kalikin L.M., Steels J.D., Estey M.P., Trimble W.S., Petty E.M. Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome 2007, 18:796-807.
4. Cerveira N., Correia C., Bizarro S., Pinto C., Lisboa S., Mariz J.M., et al. SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23). Oncogene 2006, 25:6147-6152.
5. Meyer C., Schneider B., Jakob S., Strehl S., Attarbaschi A., Schnittger S., et al. The MLL recombinome of acute leukemias. Leukemia 2006, 20:777-784.
6. Russell S.E., Hall P.A. Do septins have a role in cancer?. Br J Cancer 2005, 93:499-503.
7. Megonigal M.D., Rappaport E.F., Jones D.H., Williams T.M., Lovett B.D., Kelly K.M., et al. t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proc Natl Acad Sci USA 1998, 95:6413-6418.
8. Ono R., Taki T., Taketani T., Kawaguchi H., Taniwaki M., Okamura T., et al. SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. Cancer Res 2002, 62:333-337.
9. Osaka M., Rowley J.D., Zeleznik-Le N.J. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). Proc Natl Acad Sci USA 1999, 96:6428-6433.
10. Taki T., Ohnishi H., Shinohara K., Sako M., Bessho F., Yanagisawa M., et al. AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leulemia with t(11;17)(q23;q25). Cancer Res 1999, 59:4261-4265.
11. Kojima K., Sakai I., Hasegawa A., Niiya H., Azuma T., Matsuo Y., et al. FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). Leukemia 2004, 18:998-1005.
12. Krivtsov A.V., Armstrong S.A. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007, 7:823-833.
13. Cerveira N., Santos J., Pinheiro M., Snijder S., van der Lelie H., Mellink C.H., et al. A novel MLL-SEPT2 fusion variant in therapy-related myelodysplastic syndrome. Cancer Genet Cytogenet 2008, 185:62-64.
14. Cerveira N., Micci F., Santos J., Pinheiro M., Correia C., Lisboa S., et al. Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions. Haematologica 2008, 93:1076-1080.
15. Cerveira N., Santos J., Bizarro S., Costa V., Ribeiro F.R., Lisboa S., et al. Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related acute myeloid leukemia. BMC Cancer 2009, 9:147.
16. van Binsbergen E., de Weerdt O., Buijs A. A new subtype of MLL-SEPT2 fusion transcript in therapy-related acute myeloid leukemia with t(2;11)(q37;q23): a case report and literature review. Cancer Genet Cytogenet 2007, 176:72-75.
17. Snijder S., Mellink C.H., van der Lelie H. Translocation (2;11)(q37;q23) in therapy-related myelodysplastic syndrome after treatment for acute promyelocytic leukemia. Cancer Genet Cytogenet 2008, 180:149-152.
18. Fu J.F., Liang D.C., Yang C.P., Hsu J.J., Shih L.Y. Molecular analysis of t(X;11)(q24;q23) in an infant with AML-M4. Genes Chromosomes Cancer 2003, 38:253-259.
19. Shih L.Y., Liang D.C., Fu J.F., Wu J.H., Wang P.N., Lin T.L., et al. Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia 2006, 20:218-223.
20. Strehl S., König M., Meyer C., Schneider B., Harbott J., Jäger U., et al. Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants. Genes Chromosomes Cancer 2006, 45:1041-1049.
21. Gabert J., Beillard E., van der Velden V.H., Bi W., Grimwade D., Pallisgaard N., et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003, 17:2318-2357.
22. Beillard E., Pallisgaard N., van der Velden V.H., Bi W., Dee R., van der Schoot E., et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia. 2003, 17:2474-2486.
23. Scott M., Hyland P.L., McGregor G., Hillan K.J., Russell S.E., Hall P.A. Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumors. Oncogene 2005, 24:4688-4700.
24. Weirich C.S., Erzberger J.P., Barral Y. The septin family of GTPases: architecture and dynamics. Nat Rev Mol Cell Biol 2008, 9:478-489.
25. Kinoshita M., Field C.M., Coughlin M.L., Straight A.F., Mitchison T.J. Self- and actin-templated assembly of Mammalian septins. Dev Cell 2002, 3:791-802.
26. Kremer B.E., Haystead T., Macara I.G. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. Mol Biol Cell 2005, 16:4648-4659.
27. Whitmann S.P., Liu S., Vukosavljevic T., Rush L.J., Liu C., Klisovic M.I., et al. The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy. Blood 2005, 106:345-352.
28. Wong J.C., Le Beau M.M., Shannon K. Tumor suppressor gene inactivation in myeloid malignancies. Best Pract Res Clin Haematol 2008, 21:601-614.
29. Raj A., van Oudenaarden A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 2008, 135:216-226.
30. Elhasid R., Sahar D., Merling A., Zivony Y., Rotem A., Ben-Arush M., et al. Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients. Oncogene 2004, 23:5468-5475.
31. Gottfried Y., Rotem A., Lotan R., Steller H., Larisch S. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO J 2004, 23:1627-1635.
32. Larisch S., Yi Y., Lotan R., Kerner H., Eimerl S., Tony Parks W., et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2000, 2:915-921.
33. Kalikin L.M., Sims H.L., Petty E.M. Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors. Genomics 2000, 63:165-172.
34. Montagna C., Lyu M.S., Hunter K., Lukes L., Lowther W., Reppert T., et al. The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines. Cancer Res 2003, 63:2179-2187.
35. Scott M., McCluggage W.G., Hillan K.J., Hall P.A., Russell S.E. Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis. Int J Cancer 2006, 118:1325-1329.
36. Gonzalez M.E., Peterson E.A., Privette L.M., Loffreda-Wren J.L., Kalikin L.M., Petty E.M. High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. Cancer Res 2007, 67:8554-8564.
37. Gladfelter A.S., Montagna C. Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function. EMBO Rep 2007, 8:1120-1126.
38. Burrows J.F., Chanduloy S., McIlhatton M.A., Nagar H., Yeates K., Donaghy P., et al. Altered expression of the septin gene, SEPT9, in ovarian neoplasia. J Pathol 2003, 201:581-588.