Identification of very potent inhibitor of human aminopeptidase N (CD13)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2497-2499

  Grzywa, Renata ^a   Oleksyszyn, Józef ^a   Salvesen, Guy S ^b   Drag, Marcin ^a,b  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Aminopeptidase N; Hydroxamic acid analogues; Inhibitors; Phosphinate

Indexed keywords

ALPHA1 AMINO 3 PHENYLPROPYL (ALPHA2 HYDROXY 3 PHENYLPROPYL)PHOSPHINIC ACID; ENZYME INHIBITOR; HYDROXAMIC ACID; MICROSOMAL AMINOPEPTIDASE; PEPTIDOMIMETIC AGENT; PHOSPHINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG IDENTIFICATION; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; ORTHOLOGY; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, CD13; HUMANS; INHIBITORY CONCENTRATION 50; PROTEASE INHIBITORS;

RATTUS; SUIDAE;

EID: 77950047640     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.111     Document Type: Article

References (19)

1. Hui K.S., Wang Y.J., and Lajtha A. Biochemistry 22 (1983) 1062
2. Kokkonen J.O., Kuoppala A., Saarinen J., Lindstedt K.A., and Kovanen P.T. Circulation 99 (1999) 1984
3. Menrad A., Speicher D., Wacker J., and Herlyn M. Cancer Res. 53 (1993) 1450
4. Kanayama N., Kajiwara Y., Goto J., el Maradny E., Maehara K., Andou K., and Terao T. J. Leukocyte Biol. 57 (1995) 129
5. Hoffmann T., Faust J., Neubert K., and Ansorge S. FEBS. Lett. 336 (1993) 61
6. Danielsen E.M., and van Deurs B. Mol. Biol. Cell 8 (1997) 2241
7. Mina-Osorio P., and Ortega E. J. Leukocyte Biol. 77 (2005) 1008
8. Bauvois B., and Dauzonne D. Med. Res. Rev. 26 (2006) 88
9. Tsukamoto H., Shibata K., Kajiyama H., Terauchi M., Nawa A., and Kikkawa F. BMC Cancer 8 (2008) 74
10. Ikeda N., Nakajima Y., Tokuhara T., Hattori N., Sho M., Kanehiro H., and Miyake M. Clin. Cancer Res. 9 (2003) 1503
11. Tokuhara T., Hattori N., Ishida H., Hirai T., Higashiyama M., Kodama K., and Miyake M. Clin. Cancer Res. 12 (2006) 3971
12. Chen H.X., Roques B.P., and Fournie-Zaluski M.C. Bioorg. Med. Chem. Lett. 9 (1999) 1511
13. Zhang X., and Xu W. Curr. Med. Chem. 15 (2008) 2850
14. Drag M., Bogyo M., Ellman J.A., and Salvesen G.S. J. Biol. Chem. 285 (2010) 3310
15. Drag M., Grzywa R., and Oleksyszyn J. Bioorg. Med. Chem. Lett. 17 (2007) 1516
16. Drag M., and Oleksyszyn J. Tetrahedron Lett. 46 (2005) 3359
17. Drag M., Dlugosz K., and Oleksyszyn J. Synth. Commun. 36 (2006) 2787
18. Grzywa R., and Oleksyszyn J. Bioorg. Med. Chem. Lett. 18 (2008) 3734
19. 50 values are means of two experiments, standard deviation is ±20%. All compounds are racemic mixtures.