B-Raf kinase inhibitors: Hit enrichment through scaffold hopping

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2431-2434

  Gopalsamy, Ariamala ^a   Shi, Mengxiao ^a   Hu, Yongbo ^a   Lee, Frederick ^a   Feldberg, Larry ^a   Frommer, Eileen ^a   Kim, Steven ^a   Collins, Karen ^a   Wojciechowicz, Donald ^a   Mallon, Robert ^a  

^a WYETH RESEARCH   (United States)

Author keywords

B Raf kinase; Thienopyrimidine

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PYRIMIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; THIENOPYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL STRAIN CACO 2; CELL STRAIN HT29; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; PHARMACOPHORE; STRUCTURE ANALYSIS;

MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950041116     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.030     Document Type: Article

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