Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2435-2437

  Nakao, Akira ^a   Ohkawa, Nobuyuki ^a   Nagasaki, Takayoshi ^a   Kagari, Takashi ^a   Doi, Hiromi ^a   Shimozato, Takaichi ^a   Ushiyama, Shigeru ^a   Aoki, Kazumasa ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Analgesic and anti inflammatory agent; Cytokine; IL 1 ; p38 MAP kinase; TNF

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; LIPOPOLYSACCHARIDE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN;

ANIMALS; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; PYRIDINES; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 77950039074     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.022     Document Type: Article

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19. 50 values and their 95% C.I. values were calculated using the SAS System for Windows (SAS Institute Inc.).
20. The crude ratio of regioisomers were approximately 1:1 by NMR studies. The isolated yield indicated in Scheme 1.
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