Imatinib has a fatal impact on morphology, pairing stability and survival of adult Schistosoma mansoni in vitro

International Journal for Parasitology

Volumn 40, Issue 5, 2010, Pages 521-526

  Beckmann, S ^a   Grevelding, C G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Abl tyrosine kinase; Gastrodermis; Gonad development; Imatinib; Schistosoma mansoni

Indexed keywords

ABELSON KINASE; AMINO ACID; COMPLEMENTARY DNA; IMATINIB;

DISEASE PREVALENCE; DISEASE TREATMENT; DRUG; MORPHOLOGY; PARASITE; SURVIVAL;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DEATH; DNA SEQUENCE; DRUG FATALITY; FEMALE; GONAD DEVELOPMENT; IN VITRO STUDY; MALE; MICROBIAL MORPHOLOGY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY; TWO HYBRID SYSTEM;

ANIMALS; ANTHELMINTICS; HELMINTH PROTEINS; IN SITU HYBRIDIZATION; MICROSCOPY; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; SCHISTOSOMA MANSONI; SEQUENCE ANALYSIS, DNA; SURVIVAL ANALYSIS;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 77950022515     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2010.01.007     Document Type: Article

References (23)

1. Bahia D., Mortara R.A., Kusel J.R., Andrade L.F., Ludolf F., Kuser P.R., Avelar L., Trolet J., Dissous C., Pierce R.J., Oliveira G. Schistosoma mansoni: expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Exp. Parasitol. 2007, 116:225-232.
2. Beckmann S., Quack T., Burmeister C., Buro C., Long T., Dissous C., Grevelding C.G. Schistosoma mansoni: signal transduction processes during the development of the reproductive organs. Parasitology 2010, 137(3):497-520.
3. Beckmann S., Buro C., Hirzmann J., Dissous C., Grevelding C.G. The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis. PLoS Pathog. 2010, 6(2):e1000769. 10.1371/journal.ppat.1000769.
4. Berriman M., Haas B.J., LoVerde P.T., Wilson R.A., Dillon G.P., Cerqueira G.C., Mashiyama S.T., Al-Lazikani B., Andrade L.F., Ashton P.D., Aslett M.A., Bartholomeu D.C., Blandin G., Caffrey C.R., Coghlan A., Coulson R., Day T.A., Delcher A., DeMarco R., Djikeng A., Eyre T., Gamble J.A., Ghedin E., Gu Y., Hertz-Fowler C., Hirai H., Hirai Y., Houston R., Ivens A., Johnston D.A., Lacerda D., Macedo C.D., McVeigh P., Ning Z., Oliveira G., Overington J.P., Parkhill J., Pertea M., Pierce R.J., Protasio A.V., Quail M.A., Rajandream M.A., Rogers J., Sajid M., Salzberg S.L., Stanke M., Tivey A.R., White O., Williams D.L., Wortman J., Wu W., Zamanian M., Zerlotini A., Fraser-Liggett C.M., Barrell B.G., El-Sayed N.M. The genome of the blood fluke Schistosoma mansoni. Nature 2009, 460:352-358.
5. Cohen P. Targeting protein kinases for the development of anti-inflammatory drugs. Curr. Opin. Cell Biol. 2009, 21:317-324.
6. Deininger M.W., Goldman J.M., Melo J.V. The molecular biology of chronic myeloid leukemia. Blood 2000, 96:3343-3356.
7. Dissous C., Ahier A., Khayath N. Protein tyrosine kinases as new potential targets against human schistosomiasis. Bioessays 2007, 29:1281-1288.
8. Drucker B.J., Talpaz M., Resta D.J., Peng B., Buchdunger E., Ford J.M., Lydon N.B., Kantarjian H., Capdeville R., Ohno-Jones S., Sawyers C. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 2001, 344:1031-1037.
9. Grevelding C.G., Sommer G., Kunz W. Female-specific gene expression in Schistosoma mansoni is regulated by pairing. Parasitology 1997, 115:635-640.
10. Hubbard S.R., Till J.H. Protein tyrosine kinase structure and function. Annu. Rev. Biochem. 2000, 69:373-398.
11. Kapp K., Knobloch J., Schussler P., Sroka S., Lammers R., Kunz W., Grevelding C.G. The Schistosoma mansoni Src kinase TK3 is expressed in the gonads and likely involved in cytoskeletal organization. Mol. Biochem. Parasitol. 2004, 138:171-182.
12. Kapp K., Schussler P., Kunz W., Grevelding C.G. Identification, isolation and characterization of a Fyn-like tyrosine kinase from Schistosoma mansoni. Parasitology 2001, 122:317-327.
13. Knobloch J., Beckmann S., Burmeister C., Quack T., Grevelding C.G. Tyrosine kinase and cooperative TGFbeta signaling in the reproductive organs of Schistosoma mansoni. Exp. Parasitol. 2007, 117:318-336.
14. Knobloch J., Kunz W., Grevelding C.G. Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni. Int. J. Parasitol. 2006, 36:1261-1272.
15. Knobloch J., Winnen R., Quack M., Kunz W., Grevelding C.G. A novel Syk-family tyrosine kinase from Schistosoma mansoni which is preferentially transcribed in reproductive organs. Gene 2002, 294:87-97.
16. Larson R.A., Druker B.J., Guilhot F., O'Brien S.G., Riviere G.J., Krahnke T., Gathmann I., Wang Y. Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study. Blood 2008, 111:4022-4028.
17. Machado-Silva J.R., Lanfredi R.M., Gomes D.C. Morphological study of adult male worms of Schistosoma mansoni Sambon, 1907 by scanning electron microscopy. Mem. Inst. Oswaldo Cruz 1997, 92:647-653.
18. Manley P.W., Cowan-Jacob S.W., Buchdunger E., Fabbro D., Fendrich G., Furet P., Meyer T., Zimmermann J. Imatinib: a selective tyrosine kinase inhibitor. Eur. J. Cancer 2002, 38(Suppl. 5):S19-S27.
19. Nagar B., Bornmann W.G., Pellicena P., Schindler T., Veach D.R., Miller W.T., Clarkson B., Kuriyan J. Crystal structures oft he kinase domain of c-Abl in complex with the small molecule inhibitor PDI173955 and Imatinib (STI-571). Cancer Res. 2002, 62:4236-4243.
20. Naula C., Parsons M., Mottram J.C. Protein kinases as drug targets in trypanosomes and Leishmania. Biochim. Biophys. Acta 2005, 1754:151-159.
21. Pendergast A.M. The Abl family kinases: mechanisms of regulation and signaling. Adv. Cancer Res. 2002, 85:51-100.
22. Takahashi A., Obata Y., Fukumoto Y., Nakayama Y., Kasahara K., Kuga T., Higashiyama Y., Saito T., Yokoyama K.K., Yamaguchi N. Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Exp. Cell Res. 2009, 315:1117-1141.
23. Ward P., Equinet L., Packer J., Doerig C. Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics 2004, 5:79.