Sevoflurane hepatotoxicity: A case report of sevoflurane hepatic necrosis and review of the literature

American Journal of Therapeutics

Volumn 17, Issue 2, 2010, Pages 219-222

  Singhal, Shashideep ^a   Gray, Tedra ^b   Guzman, Grace ^c   Verma, Arun ^b   Anand, Kris ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b Mt Sinai Medical Center   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Anesthesia; EBV; Hepatitis; Risk factors; Sevoflurane

Indexed keywords

CODEINE; HEPATITIS A ANTIBODY; MIDAZOLAM; NITROGEN OXIDE; PARACETAMOL; PROPOFOL; SEVOFLURANE;

ABDOMINAL MASS; ABDOMINAL PAIN; ABDOMINAL SURGERY; ABDOMINAL WALL; ADULT; ANALGESIA; ANAMNESIS; ANESTHESIA; ARTICLE; CASE REPORT; CENTRILOBULAR CHOLESTATIC HEPATOCELLULAR INJURY; GENERAL ANESTHESIA; HISTOPATHOLOGY; HOSPITAL DISCHARGE; HUMAN; JAUNDICE; LABORATORY TEST; LIVER BIOPSY; LIVER NECROSIS; LIVER TOXICITY; MALE; NAUSEA; PATIENT TRANSPORT; PRIORITY JOURNAL; SEROLOGY; SQUAMOUS CELL CARCINOMA; VOMITING;

ADULT; ANESTHETICS, INHALATION; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; HUMANS; LIVER; MASSIVE HEPATIC NECROSIS; METHYL ETHERS;

EID: 77949964678     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/MJT.0b013e318197eacb     Document Type: Article

References (15)

1. Reich A, Everding AS, Bulla M, et al. Hepatitis after sevoflurane exposure in an infant suffering from primary hyperoxaluria type 1. Anesth Analg. 2004;99(2):370-372.
2. Jang Y, Kim I. Severe hepatotoxicity after sevoflurane anesthesia in a child with mild renal dysfunction. Paediatr Anaesth. 2005;15:1140-1144.
3. Turillazzi E, D,Errico S, Neri M, et al. A fatal case of fulminant hepatic necrosis following sevoflurane anesthesia. Toxicol Pathol. 2007;35:840-845.
4. Lehmann A, Neher M, Kiessling AH, et al. Case report: fatal hepatic failure after aortic valve replacement and sevoflurane exposure. Can J Anaesth. 2007;54: 917-921.
5. Nelson PD, Ferguson CN, Jones RM. Anaesthetic organ toxicity: is it really a problem? Curr Opin Anaesthesiol. 1998;11:399-401.
6. Holaday DA, Smith PR. Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers. Anesthesiology. 1981;54:100-106.
7. Kharasch ED, Karol MD, Lanni C, et al. Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics. Anesthesiology. 1995;82: 1369-1378.
8. Njoku D, Laster MJ, Gong DH, et al. Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury. Anesth Analg. 1997; 84:173-178.
9. Bernard JM, Doursout MF, Wouters P, et al. Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dog. Anesthesiology. 1992;77: 541-545.
10. Martin JL. Volatile anesthetics and liver injury: a clinical update or what every anesthesiologist should know. Can J Anaesth. 2005;52:125-129.
11. Zheng XH, Begay C, Lind RC, et al. Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure. Drug Chem Toxicol. 2001;24:339-346.
12. Dikmen B, Unal Y, Pampal HK, et al. Effects of repeated desflurane and sevoflurane anesthesia on enzymatic free radical scavenger system. Mol Cell Biochem. 2007;294(1-2): 31-36.
13. Dumortier J, Mekki Y, Rimmelé T, et al. EBV-induced fulminant hepatic failure: favorable outcome after liver transplantation. Gastroenterol Clin Biol. 2007;31: 725-728.
14. Ader F, Chatellier D, Le Berre R, et al. Fulminant Epstein- Barr virus (EBV) hepatitis in a young immunocompetent subject. Med Mal Infect. 2006;36:396-398.
15. Petrova M, Muhtarova M, Nikolova M, et al. Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients. World J Gastroenterol. 2006;12:5711-5716.