Disparity in productive binding mode of the slow-reacting enantiomer determines the novel catalytic behavior of Candida antarctica lipase B

Journal of Molecular Catalysis B: Enzymatic

Volumn 62, Issue 3-4, 2010, Pages 288-296

  Xu, Tao ^a   Zhang, Lujia ^a   Su, Erzheng ^a   Cui, Dongbing ^a   Wang, Xuedong ^a   Wei, Dongzhi ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Candida antarctica lipase B; Enantioselectivity; Molecular dynamics simulation; Productive binding mode

Indexed keywords

BINDING MODES; CANDIDA ANTARCTICA LIPASE B; CATALYTIC BEHAVIOR; ENZYME ENANTIOSELECTIVITY; IN-SILICO; MEDIUM SIZE; MODELING RESULTS; MOLECULAR DYNAMICS SIMULATIONS; SECONDARY ALCOHOLS; STEREOSPECIFICITY; STRUCTURAL DIFFERENCES; SUBSTRATE BINDING; TRANSITION STATE;

BINDING ENERGY; CHIRALITY; ELECTRON TRANSITIONS; ENANTIOMERS; ENANTIOSELECTIVITY; ENZYMES; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; REACTION INTERMEDIATES; REACTION KINETICS;

SUBSTRATES;

ALCOHOL; BACTERIAL ENZYME; HALOGEN; LIPASE B;

ARTICLE; BINDING KINETICS; CANDIDA ANTARCTICA; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; MOLECULAR DYNAMICS; NONHUMAN; STEREOSPECIFICITY;

CANDIDA ANTARCTICA;

EID: 77949918875     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2009.11.011     Document Type: Article

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