Combined warfarin-aspirin therapy: What is the evidence for benefit and harm and which patients should (and should not) receive it?

Journal of Thrombosis and Thrombolysis

Volumn 29, Issue 2, 2010, Pages 208-213

  Donadini, Marco P ^a   Douketis, James D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Antiplatelet therapy; Combined warfarin aspirin; Evidence; Harm; Oral anticoagulants; Therapeutic benefit

Indexed keywords

ACETYLSALICYLIC ACID; ANTIVITAMIN K; CLOPIDOGREL; WARFARIN; XIMELAGATRAN;

ACUTE CORONARY SYNDROME; BLEEDING; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONFERENCE PAPER; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; CORONARY ARTERY THROMBOSIS; CORONARY STENT; DRUG EFFICACY; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART REINFARCTION; HEART VALVE PROSTHESIS; HIGH RISK PATIENT; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOW DRUG DOSE; PRIMARY PREVENTION; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; SECONDARY PREVENTION; STENT THROMBOSIS; THROMBOEMBOLISM; TRANSIENT ISCHEMIC ATTACK; VENOUS THROMBOEMBOLISM;

ANTICOAGULANTS; ASPIRIN; DRUG THERAPY, COMBINATION; EVIDENCE-BASED MEDICINE; FIBRINOLYTIC AGENTS; HUMANS; PATIENT SELECTION; PLATELET AGGREGATION INHIBITORS; PRACTICE GUIDELINES AS TOPIC; RISK ASSESSMENT; THROMBOEMBOLISM; TREATMENT OUTCOME; WARFARIN;

EID: 77949913752     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-009-0413-4     Document Type: Conference Paper

References (14)

1. SG Johnson DM Witt TR Eddy T Delate 2007 Warfarin and antiplatelet combination use among commercially insured patients enrolled in a anticoagulation management service Chest 131 1500 1507 10.1378/chest.06-2374 1:CAS:528:DC%2BD2sXmt1Cku7c%3D 17494799 (Pubitemid 46762359)
2. AS Go EM Hylek JA Phillips YC Chang LE Henault JV Selby DE Singer 2001 Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study JAMA 285 2370 2375 10.1001/jama.285.18.2370 1:STN:280:DC%2BD3M3ntleitQ%3D%3D 11343485
3. National Heart, Lung, and Blood Institute (2007) Morbidity and mortality: 2007 chart book on cardiovascular, lung, and blood disease. Bethesda (MD). http://www.nhlbi.nih.gov/resources/docs/cht-book.htm
4. F Dentali JD Douketis W Lim M Crowther 2007 Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease Arch Intern Med 167 117 124 10.1001/archinte.167.2.117 1:CAS:528:DC%2BD2sXhvFKms7w%3D 17242311 (Pubitemid 46148058)
5. RF Van Es JJC Jonker FWA Verheugt JW Deckers DE Grobbee 2002 Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): a randomised controlled trial Lancet 360 109 113 10.1016/S0140-6736(02)09409-6 12126819
6. M Hurlen M Abdelnoor P Smith J Erikssen Arnesen 2002 Warfarin, aspirin, or both after myocardial infarction N Engl J Med 347 969 974 10.1056/NEJMoa020496 1:CAS:528:DC%2BD38Xnt12rtLY%3D 12324552
7. GC Flacker M Gruber SJ Connolly S Goldman S Chaparro A Vahanian MO Halinen J Horrow JL Halperin 2006 Risk and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials Am Heart J 152 967 973 10.1016/j.ahj.2006.06.024 (Pubitemid 44637136)
8. SG Johnson K Rogers T Delate DM Witt 2008 Outcomes associated with combined antiplatelet and anticoagulant therapy Chest 133 948 954 10.1378/chest.07-2627 1:CAS:528:DC%2BD1cXls1CltrY%3D 18198244
9. L Linkins PT Choi JD Douketis 2003 Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism Ann Intern Med 139 893 900 14644891
10. J Douketis K Arneklev SZ Goldhaber J Spandorfer F Halperin J Horrow 2006 Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin Arch Intern Med 166 853 859 10.1001/archinte.166. 8.853 1:CAS:528:DC%2BD28Xkslensrk%3D 16636210
11. RC Becker TW Meade PB Berger M Ezekowitz CM O'Connor DA Vorchheimer GH Guyatt DB Mark RA Harrington 2008 The primary and secondary prevention of coronary artery disease. American college of chest physicians evidence-based clinical practice guidelines (8th edition) Chest 133 776S 814S 10.1378/chest.08-0685 1:CAS:528:DC%2BD1cXptVKhs7c%3D 18574278
12. V Fuster LE Rydén DS Cannom, et al. 2006 ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation - executive summary Circulation 114 700 752 10.1161/CIRCULATIONAHA.106.177031 (Pubitemid 44252312)
13. DN Salem PT O'Gara C Madias SG Pauker 2008 Valvular and structural heart disease. American college of chest physicians evidence-based clinical practice guidelines (8th edition) Chest 133 593S 629S 10.1378/chest.08-0724 18574274
14. RO Bonow BA Carabello K Chatterjee, et al. 2006 ACC/AHA 2006 guidelines for the management of patients with valvular heart disease - executive summary Circulation 114 450 527 10.1161/CIRCULATIONAHA.106.176857 (Pubitemid 44268973)